Cdk1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdk1
cyclin dependent kinase 1
MGI:88351

24 phenotypes from 7 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdk1^{Gt(P009F08)Bbd}/Cdk1^{Gt(P009F08)Bbd} involves: 129/Sv * 129X1/SvJ * C57BL/6	embryonic lethality before implantation, complete penetrance	J:124678
Cdk1^{Gt(P009F08)Bbd}/Cdk1^{Gt(pGT1-3)1Bbd} involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6	embryonic lethality during organogenesis, complete penetrance	J:124678
Cdk1^{Gt(pGT1-3)1Bbd}/Cdk1^{Gt(pGT1-3)1Bbd} involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	embryonic lethality before implantation, complete penetrance	J:124678
Cdk1^tm1Eddy/Cdk1^tm1Eddy Tg(Cryaa-cre)10Mlr/0 involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N	abnormal lens development	J:214812
	abnormal lens epithelium morphology	J:214812
	abnormal lens fiber morphology	J:214812
Cdk1^tm2.1Kald/Cdk1^tm2.1Kald Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129 * C57BL/6 * DBA * SJL	abnormal hepatocyte morphology	J:182141
	abnormal mitosis	J:182141
	abnormal response to injury	J:182141
	decreased hepatocyte number	J:182141
	decreased hepatocyte proliferation	J:182141
	decreased incidence of induced tumors	J:182141
	polyploidy	J:182141
Cdk1^tm2.1Kald/Cdk1^tm2.1Kald Tg(CAG-cre/Esr1)5Amc/0 involves: 129 C57BL/6 * CBA * SJL	abnormal DNA replication	J:182141
	decreased cell proliferation	J:182141
	decreased tumor growth/size	J:182141
	early cellular replicative senescence	J:182141
Cdk1^tm2.2Kald/Cdk1^tm2.2Kald involves: 129 * C57BL/6 * FVB/N * SJL	abnormal blastocyst morphology	J:182141
	abnormal cell nucleus count	J:182141
	abnormal cell nucleus morphology	J:182141
	embryonic lethality, complete penetrance	J:182141
	failure of zygotic cell division	J:182141
Cdk1^tm3.1Kald/Cdk1⁺ involves: 129 * C57BL/6	embryonic lethality, complete penetrance	J:251984
Cdk1^tm3Kald/Cdk1⁺ Tg(Stra8-icre)1Reb/0 involves: 129 * C57BL/6 * FVB/NJ	arrest of male meiosis	J:251984
	azoospermia	J:251984
	small testis	J:251984

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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