Cdh2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdh2
cadherin 2
MGI:88355

68 phenotypes from 6 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdh2^em1Obir/Cdh2^em1Obir C57BL/6JRcc-Cdh2^em1Obir	abnormal prepulse inhibition	J:331911
	abnormal sensorimotor gating	J:331911
	abnormal synapse morphology	J:331911
	abnormal synaptic vesicle clustering	J:331911
	abnormal synaptic vesicle number	J:331911
	abnormal synaptic vesicle recycling	J:331911
	decreased aggression towards male mice	J:331911
	decreased dopaminergic neuron number	J:331911
	decreased exploration in new environment	J:331911
	decreased miniature excitatory postsynaptic current frequency	J:331911
	decreased nervous system dopamine level	J:331911
	decreased neurotransmitter release	J:331911
	hyperactivity	J:331911
	impaired synaptic plasticity	J:331911
	increased startle reflex	J:331911
Cdh2^em2Obir/Cdh2^em2Obir C57BL/6JRcc-Cdh2^em2Obir	hyperactivity	J:331911
Cdh2^{Gt(OST49160)Lex}/Cdh2^{Gt(OST49160)Lex} involves: 129S5/SvEvBrd	abnormal brain development	J:95209
	abnormal heart tube morphology	J:95209
	pericardial edema	J:95209
	prenatal lethality, complete penetrance	J:95209
Cdh2^tm1.1Ayki/Cdh2^tm1.1Ayki involves: C57BL/6 * DBA/2	abnormal asymmetric synapse morphology	J:302799
	abnormal CNS synaptic transmission	J:302799
	abnormal excitatory postsynaptic potential	J:302799
	abnormal hippocampus pyramidal cell morphology	J:302799
	abnormal postsynaptic density morphology	J:302799
	enhanced cued conditioning behavior	J:302799
	enhanced long-term potentiation	J:302799
	enhanced spatial working memory	J:302799
	normal growth/size/body region phenotype	J:302799
	normal nervous system phenotype	J:302799
	normal reproductive system phenotype	J:302799
Cdh2^tm1Glr/Cdh2^{Gt(OST49160)Lex} A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf⁺ involves: 129S5/SvEvBrd 129S6/SvEvTac * C57BL/6J * FVB/N	abnormal cardiovascular system morphology	J:98828
	abnormal cardiovascular system physiology	J:98828
	abnormal heart shape	J:98828
	abnormal impulse conducting system conduction	J:98828
	abnormal intercalated disk morphology	J:98828
	abnormal myocardial fiber morphology	J:98828
	decreased cardiac output	J:98828
	decreased heart left ventricle muscle contractility	J:98828
	decreased heart rate	J:98828
	dilated heart atrium	J:98828
	dilated heart left ventricle	J:98828
	dilated heart right ventricle	J:98828
	increased heart rate	J:98828
	irregular heartbeat	J:98828
	premature death	J:98828
Cdh2^tm1Glr/Cdh2^tm1Glr Emx1^tm1(cre)Krj/Emx1⁺ involves: 129S6/SvEvTac * C57BL/6	abnormal cerebral cortex morphology	J:215584
	abnormal cortical ventricular zone morphology	J:215584
	abnormal neocortex morphology	J:215584
	abnormal nervous system tract morphology	J:215584
	abnormal radial glial cell morphology	J:215584
	ectopic neuron	J:215584
	increased neuronal precursor cell number	J:215584
	thickened cerebral cortex	J:215584
Cdh2^tm1Glr/Cdh2^tm1Glr Olig2^tm1(cre)Tmj/Olig2⁺ involves: 129S6/SvEvTac	abnormal neuronal migration	J:178688
	abnormal spinal cord morphology	J:178688
	abnormal spinal cord motor column morphology	J:178688
	lethality throughout fetal growth and development, incomplete penetrance	J:178688
	neonatal lethality, complete penetrance	J:178688
Cdh2^tm1Glr/Cdh2^tm1Hyn A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf⁺ involves: 129S6/SvEvTac C57BL/6J * FVB/N	abnormal cardiovascular system morphology	J:98828
	abnormal cardiovascular system physiology	J:98828
	abnormal heart shape	J:98828
	abnormal impulse conducting system conduction	J:98828
	abnormal intercalated disk morphology	J:98828
	abnormal myocardial fiber morphology	J:98828
	decreased cardiac output	J:98828
	decreased heart left ventricle muscle contractility	J:98828
	decreased heart rate	J:98828
	dilated heart atrium	J:98828
	dilated heart left ventricle	J:98828
	dilated heart right ventricle	J:98828
	increased heart rate	J:98828
	irregular heartbeat	J:98828
	premature death	J:98828
Cdh2^tm1Hyn/Cdh2^tm1Hyn involves: 129S2/SvPas	abnormal embryo turning	J:37888
	abnormal heart tube morphology	J:37888
	abnormal myocardial fiber morphology	J:37888
	abnormal myocardium layer morphology	J:37888
	abnormal somite shape	J:37888, J:58409
	abnormal visceral yolk sac morphology	J:37888
	abnormal vitelline vasculature morphology	J:37888
	distended pericardium	J:37888
	embryonic growth retardation	J:37888
	embryonic lethality during organogenesis, complete penetrance	J:37888
	enlarged heart	J:37888
	wavy neural tube	J:37888

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24