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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cdk4
cyclin dependent kinase 4
MGI:88357
67 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cdk2tm1Kald/Cdk2tm1Kald
Cdk4tm1Kiyo/Cdk4tm1Kiyo
involves: 129S1/Sv * C57BL/6 		abnormal cardiac output J:108720
abnormal cell cycle J:108720
abnormal erythrocyte morphology J:108720
abnormal eye morphology J:108720
abnormal fetal cardiomyocyte proliferation J:108720
abnormal heart valve morphology J:108720
abnormal hematopoietic stem cell morphology J:108720
abnormal liver morphology J:108720
decreased cell proliferation J:108720
decreased embryo size J:108720
edema J:108720
hemorrhage J:108720
increased heart atrium size J:108720
lethality throughout fetal growth and development, incomplete penetrance J:108720
myocardial fiber disarray J:108720
pallor J:108720
small heart J:108720
thin ventricular wall J:108720
ventricular septal defect J:108720
Cdk2tm1Kald/Cdk2tm1Kald
Cdk4tm1Kiyo/Cdk4tm1Kiyo
Cdkn1btm1Ako/Cdkn1btm1Ako
involves: 129S1/Sv * C57BL/6 		decreased cell proliferation J:108720
lethality throughout fetal growth and development, complete penetrance J:108720
Cdk2tm1Sgo/Cdk2+
Cdk4tm2.1Bbd/Cdk4+
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL 		abnormal embryo development J:125217
Cdk2tm1Sgo/Cdk2tm1Sgo
Cdk4tm1Bbd/Cdk4tm1Bbd
Cdk6tm1Bbd/Cdk6tm1Bbd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal common myeloid progenitor cell morphology J:124678
decreased cell proliferation J:124678
decreased embryo size J:124678
decreased myocardial fiber number J:124678
embryonic lethality during organogenesis, incomplete penetrance J:124678
lethality throughout fetal growth and development, complete penetrance J:124678
liver hypoplasia J:124678
thin ventricular wall J:124678
Cdk2tm1Sgo/Cdk2tm1Sgo
Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL 		abnormal cell cycle J:125217
abnormal definitive hematopoiesis J:125217
abnormal fetal cardiomyocyte proliferation J:125217
abnormal liver physiology J:125217
congestive heart failure J:125217
decreased body weight J:125217
decreased erythrocyte cell number J:125217
decreased fibroblast proliferation J:125217
increased myocardial fiber size J:125217
liver hypoplasia J:125217
neonatal lethality, complete penetrance J:125217
thin ventricular wall J:125217
Cdk2tm2Sgo/Cdk2tm2Sgo
Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Polr2atm1(cre/ERT2)Bbd/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		decreased body size J:125217
normal hematopoietic system phenotype J:125217
increased susceptibility to autoimmune diabetes J:125217
normal liver/biliary system phenotype J:125217
Cdk4tm1.1Bbd/Cdk4+
Tg(Mt1-Hgf)#Lmb/0
B6.Cg-Cdk4tm1.1Bbd Tg(Mt1-Hgf)#Lmb 		abnormal axillary lymph node morphology J:111992
abnormal inguinal lymph node morphology J:111992
decreased tumor growth/size J:111992
enlarged axillary lymph nodes J:111992
enlarged inguinal lymph nodes J:111992
increased incidence of tumors by chemical induction J:111992
increased metastatic potential J:111992
Cdk4tm1.1Bbd/Cdk4+
Krastm1Bbd/Kras+
Tg(CMV-cre)1Cgn/?
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 		abnormal pancreatic duct morphology J:86101
increased hemangiosarcoma incidence J:86101
increased lung adenoma incidence J:86101
increased papilloma incidence J:86101
increased pituitary adenoma incidence J:86101
increased sarcoma incidence J:86101
Cdk4tm1.1Bbd/Cdk4tm1.1Bbd
Krt14tm1(cre)Wbm/Krt14+
Pard3tm1Shoh/Pard3tm1Shoh
Tg(Mt1-Hgf)#Lmb/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J 		increased incidence of tumors by chemical induction J:240961
increased metastatic potential J:240961
increased tumor growth/size J:240961
Cdk4tm1.1Bbd/Cdk4tm1.1Bbd
Tg(Mt1-Hgf)#Lmb/0
B6.Cg-Cdk4tm1.1Bbd Tg(Mt1-Hgf)#Lmb 		abnormal axillary lymph node morphology J:111992
abnormal inguinal lymph node morphology J:111992
enlarged axillary lymph nodes J:111992
enlarged inguinal lymph nodes J:111992
increased cutaneous melanoma incidence J:111992
increased incidence of tumors by chemical induction J:111992
increased metastatic potential J:111992
increased skin tumor incidence J:111992
increased tumor growth/size J:111992
Cdk4tm1.1Bbd/Cdk4tm1.1Bbd
Tg(Tyr-NRAS*Q61K)1Bee/0
FVB.Cg-Cdk4tm1.1Bbd Tg(Tyr-NRAS*Q61K)1Bee 		abnormal melanocyte proliferation J:222847
increased cutaneous melanoma incidence J:222847
increased incidence of tumors by UV-induction J:222847
increased melanocyte number J:222847
skin lesions J:222847
Cdk4tm1Bbd/Cdk4tm1Bbd
Cdk6tm1Bbd/Cdk6tm1Bbd
involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR 		abnormal erythrocyte morphology J:92529
decreased embryo size J:92529
decreased erythrocyte cell number J:92529
decreased hematopoietic stem cell number J:92529
extramedullary hematopoiesis J:92529
lethality throughout fetal growth and development, incomplete penetrance J:92529
liver hypoplasia J:92529
neonatal lethality, complete penetrance J:92529
Cdk4tm1Kiyo/Cdk4+
Lin9tm1Orc/Lin9+
involves: 129S1/Sv 		abnormal cell cycle J:111333
decreased susceptibility to autoimmune diabetes J:111333
Cdk4tm1Kiyo/Cdk4tm1Kiyo
Lin9tm1Orc/Lin9tm1Orc
involves: 129S1/Sv 		abnormal cell cycle J:111333
adenohypophysis hypoplasia J:111333
decreased body weight J:111333
female infertility J:111333
male infertility J:111333
Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Krastm1Bbd/Krastm2Bbd
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
involves: 129S1/Sv * 129X1/SvJ 		decreased cell proliferation J:161780
decreased tumor growth/size J:161780
early cellular replicative senescence J:161780
increased adenocarcinoma incidence J:161780
Cdk4tm2.2Bbd/Cdk4tm2.1Bbd
Krastm1Bbd/Krastm2Bbd
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
involves: 129S1/Sv * 129X1/SvJ 		decreased cell proliferation J:161780
decreased tumor growth/size J:161780
decreased tumor incidence J:161780
early cellular replicative senescence J:161780
increased tumor incidence J:161780
Cdk4tm2.2Bbd/Cdk4tm2.2Bbd
Krastm1Bbd/Krastm1Bbd
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
involves: 129S1/Sv * 129X1/SvJ 		decreased tumor incidence J:161780
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
MGI 6.24 		The Jackson Laboratory