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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cdx2
caudal type homeobox 2
MGI:88361
69 phenotypes from 9 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cdx2tm1.1Aral/Cdx2tm1.1Aral
Tg(Zp3-cre)93Knw/0
involves: 129X1/SvJ * C57BL/6 * CD-1 * SJL 		normal reproductive system phenotype J:189005
Cdx2tm1.1Aral/Cdx2tm1.2Aral
Tg(Zp3-cre)93Knw/0
involves: 129X1/SvJ * C57BL/6 * CD-1 * SJL 		normal reproductive system phenotype J:189005
Cdx2tm1.1Aral/Cdx2tm1Fbe
Tg(Zp3-cre)93Knw/0
involves: 129X1/SvJ * C57BL/6 * CD-1 * SJL 		embryonic growth arrest J:189005
embryonic lethality before implantation, complete penetrance J:189005
Cdx2tm1.1Lhn/Cdx2+
Tg(CAG-cre/ERT2)F34Fmr/0
involves: 129S1/Sv * 129X1/SvJ * CD-1 		absent tail J:154904
short tail J:154904
sirenomelia J:154904
Cdx2tm1.1Lhn/Cdx2tm1.1Lhn
Tg(CAG-cre/ERT2)F34Fmr/0
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal mesoderm development J:154904
abnormal presomitic mesoderm morphology J:154904
absent hindlimb buds J:154904
decreased somite size J:154904
embryonic lethality during organogenesis, complete penetrance J:154904
impaired somite development J:154904
short rostral-caudal axis J:154904
Cdx2tm1.2Aral/Cdx2tm1Fbe
involves: 129X1/SvJ * C57BL/6 * CD-1 * SJL 		embryonic growth arrest J:189005
embryonic lethality before implantation, complete penetrance J:189005
Cdx2tm1Fbe/Cdx2+
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal placenta labyrinth morphology J:104372
failure of chorioallantoic fusion J:104372
Cdx2tm1Fbe/Cdx2+
involves: 129S1/Sv * C57BL/6J 		abnormal rib morphology J:38772
cervical vertebral transformation J:38772
decreased body weight J:38772
increased colon adenoma incidence J:38772
increased intestinal adenoma incidence J:38772
kinked tail J:38772
short tail J:38772
thoracic vertebral transformation J:38772
vertebral transformation J:38772
Cdx2tm1Fbe/Cdx2tm1Fbe
involves: 129S1/Sv * C57BL/6J 		embryonic lethality, complete penetrance J:38772
failure of embryo implantation J:38772
Cdx2tm1Fbe/Cdx2tm1Fbe
involves: ICR 		abnormal blastocoele morphology J:98502
abnormal blastocyst morphology J:98502
abnormal inner cell mass apoptosis J:98502
abnormal trophectoderm morphology J:98502
abnormal trophoblast layer morphology J:98502
absent trophoblast giant cells J:98502
embryonic lethality before implantation, complete penetrance J:98502
failure of blastocyst to hatch from the zona pellucida J:98502
increased trophectoderm apoptosis J:98502
Cdx2tm1Fbe/Cdx2tm2.1Fbe
involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ 		caudal body truncation J:179732
Cdx2tm1Fbe/Cdx2tm2Fbe
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CBA 		caudal body truncation J:179732
Cdx2tm1Khk/Cdx2tm1Khk
involves: C57BL/6 * SJL 		no abnormal phenotype detected J:149479
Cdx2tm1Khk/Cdx2tm1Khk
Tg(Foxa3-cre)1Khk/0
involves: C57BL/6 * DBA * SJL 		abnormal cecum morphology J:149479
abnormal digestive system development J:149479
abnormal duodenum morphology J:149479
abnormal enteroendocrine cell morphology J:149479
abnormal hindgut morphology J:149479
abnormal intestinal epithelium morphology J:149479
abnormal intestinal goblet cell morphology J:149479
abnormal intestine morphology J:149479
absent colon J:149479
absent enterocytes J:149479
decreased small intestinal villus size J:149479
distended duodenum J:149479
neonatal lethality, complete penetrance J:149479
Cdx2tm1Mmt/Cdx2+
B6.129X1-Cdx2tm1Mmt 		abnormal cell cycle checkpoint function J:86737
abnormal chromosome morphology J:86737
abnormal colon morphology J:86737
abnormal small intestine morphology J:86737
decreased apoptosis J:86737
increased apoptosis J:86737
Cdx2tm1Mmt/Cdx2+
involves: 129X1/SvJ * C57BL/6 		abnormal cecum morphology J:47050
abnormal colon morphology J:47050
abnormal rib morphology J:47050
colon polyps J:47050
decreased body size J:47050
increased colon hamartoma incidence J:47050
vertebral transformation J:47050
Cdx2tm1Mmt/Cdx2tm1Mmt
involves: 129X1/SvJ * C57BL/6 		absent inner cell mass proliferation J:47050
embryonic lethality between implantation and somite formation, complete penetrance J:47050
Cdx2tm1Yxz/Cdx2tm1Yxz
involves: 129S4/SvJae * C57BL/6 * CD-1 		no abnormal phenotype detected J:186304
Cdx2tm2.1Fbe/Cdx2+
involves: 129P2/OlaHsd * BALB/cJ 		intestine polyps J:179732
Cdx2tm2Fbe/Cdx2tm2Fbe
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * C57BL/6 		abnormal cell migration J:179732
abnormal crypts of Lieberkuhn morphology J:179732
abnormal intestine physiology J:179732
abnormal Paneth cell physiology J:179732
increased Paneth cell number J:179732
Cdx2tm2Fbe/Cdx2tm2Fbe
Tg(Cyp1a1-cre/ERT)1Dwi/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal cell migration J:179732
abnormal crypts of Lieberkuhn morphology J:179732
abnormal ileum morphology J:179732
abnormal intestinal mucosa morphology J:179732
abnormal intestine physiology J:179732
abnormal Paneth cell physiology J:179732
abnormal small intestinal villus morphology J:179732
cecum polyps J:179732
increased Paneth cell number J:179732
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
MGI 6.24 		The Jackson Laboratory