Cebpb Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cebpb
CCAAT/enhancer binding protein beta
MGI:88373

59 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cebpa^{tm1.1(Cebpb)Ylee}/Cebpa^{tm1.1(Cebpb)Ylee} involves: 129X1/SvJ * C57BL/6 * FVB/N	abnormal brown adipose tissue morphology	J:77646
	abnormal fat cell morphology	J:77646
	abnormal hematopoietic system physiology	J:77646
	abnormal white adipose tissue morphology	J:77646
	decreased circulating leptin level	J:77646
	decreased white adipose tissue amount	J:77646
	normal growth/size/body region phenotype	J:77646
	normal homeostasis/metabolism phenotype	J:77646
	normal immune system phenotype	J:77646
	increased brown adipose tissue amount	J:77646
	increased food intake	J:77646
	normal reproductive system phenotype	J:77646
Cebpa^{tm1.1(Cebpb)Ylee}/Cebpa^tm1.1Gonz involves: 129X1/SvJ * C57BL/6 * FVB/N	abnormal white adipose tissue morphology	J:77646
	decreased white adipose tissue amount	J:77646
Cebpa^tm1Gonz/Cebpa⁺ Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	normal integument phenotype	J:154022
Cebpa^tm1Gonz/Cebpa^tm1Gonz Cebpb^tm1Es/Cebpb^tm1Es Tg(KRT14-cre/ERT)20Efu/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1	abnormal epidermal layer morphology	J:158721
	abnormal epidermis stratum basale morphology	J:158721
	abnormal epidermis stratum spinosum morphology	J:158721
	abnormal epidermis suprabasal layer morphology	J:158721
	abnormal eye morphology	J:158721
	abnormal hair follicle infundibulum morphology	J:158721
	abnormal keratinocyte differentiation	J:158721
	abnormal male preputial gland morphology	J:158721
	abnormal Meibomian gland morphology	J:158721
	abnormal sebaceous gland morphology	J:158721
	abnormal sebaceous lipid secretion	J:158721
	abnormal sebocyte differentiation	J:158721
	abnormal sebocyte morphology	J:158721
	dry eyes	J:158721
	epidermal hyperplasia	J:158721
	hair follicle outer root sheath hyperplasia	J:158721
	hyperkeratosis	J:158721
	increased keratinocyte proliferation	J:158721
	Meibomian gland atrophy	J:158721
	parakeratosis	J:158721
Cebpa^tm1Gonz/Cebpa^tm1Gonz Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	abnormal epidermal layer morphology	J:154022
	eyelids open at birth	J:154022
	increased keratinocyte proliferation	J:154022
	neonatal lethality, complete penetrance	J:154022
	parakeratosis	J:154022
	shiny skin	J:154022
	tight skin	J:154022
	weight loss	J:154022
Cebpa^tm1Gonz/Cebpa^tm2Nerl Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	abnormal epidermis stratum corneum morphology	J:154022
	abnormal epidermis stratum granulosum morphology	J:154022
	increased keratinocyte proliferation	J:154022
	shiny skin	J:154022
Cebpa^tm1Gonz/Cebpa^tm9Nerl Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	absent epidermis stratum corneum	J:154022
	absent epidermis stratum granulosum	J:154022
	increased keratinocyte proliferation	J:154022
	parakeratosis	J:154022
	shiny skin	J:154022
Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Ins2^Akita/Ins2^Akita Tg(Ins2-cre)23Herr/0 involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J	abnormal pancreatic beta cell mass	J:156725
	abnormal pancreatic islet cell apoptosis	J:156725
	decreased circulating insulin level	J:156725
	decreased insulin secretion	J:156725
	increased circulating glucose level	J:156725
Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Lepr^db/Lepr^db Tg(Ins2-cre)23Herr/0 involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J	abnormal pancreatic islet cell apoptosis	J:156725
	hyperglycemia	J:156725
	increased circulating insulin level	J:156725
	increased pancreatic beta cell mass	J:156725
Cebpb^tm1Kish/Cebpb^tm1Kish Cebpd^tm1Aki/Cebpd^tm1Aki involves: 129P2/OlaHsd	abnormal brown adipose tissue thermogenesis	J:45062
	abnormal brown fat cell morphology	J:45062
	abnormal brown fat lipid droplet number	J:45062
	abnormal cell differentiation	J:45062
	decreased epididymal fat pad weight	J:45062
	decreased white adipose tissue amount	J:45062
	neonatal lethality, complete penetrance	J:45062
	perinatal lethality, incomplete penetrance	J:45062
Cebpb^tm1Pfj/Cebpb^tm1Pfj Tg(Hba-x-v-Ha-ras)TG.ACLed/0 involves: C57BL/6	decreased incidence of tumors by chemical induction	J:73558
	decreased tumor growth/size	J:73558
Cebpb^tm1Vpo/Cebpb^tm1Vpo Il6^tm1Poli/Il6^tm1Poli involves: 129S/SvEv * MF1	normal hematopoietic system phenotype	J:35883

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24