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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		F3
coagulation factor III
MGI:88381
63 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
F3tm1.1Dwr/F3tm1.1Dwr
B6.129-F3tm1.1Dwr 		abnormal induced retina neovascularization J:135087
F3tm1.1Dwr/F3tm1.1Dwr
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 		normal hematopoietic system phenotype J:71271
F3tm1.1Dwr/F3tm1.1Dwr
involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss 		abnormal blood coagulation J:91165
abnormal cellular extravasation J:91165
abnormal leukocyte adhesion J:91165
abnormal vascular smooth muscle physiology J:111390
abnormal vascular wound healing J:111390
decreased B cell number J:91165
decreased circulating interleukin-1 beta level J:91165
decreased circulating interleukin-6 level J:91165
decreased circulating tumor necrosis factor level J:91165
decreased leukocyte cell number J:91165
decreased neutrophil cell number J:91165
decreased susceptibility to endotoxin shock J:91165
decreased susceptibility to induced morbidity/mortality J:91165
impaired leukocyte tethering or rolling J:91165
increased vascular smooth muscle cell proliferation J:111390
F3tm1Dco/F3tm1Dco
Not Specified 		abnormal embryo development J:35120
abnormal embryonic tissue morphology J:35120
abnormal extraembryonic tissue morphology J:35120
abnormal vitelline vasculature morphology J:35120
absent vitelline blood vessels J:35120
disorganized yolk sac vascular plexus J:35120
embryo tissue necrosis J:35120
embryonic lethality during organogenesis, complete penetrance J:35120
enlarged pericardium J:35120
pale yolk sac J:35120
pallor J:35120
F3tm1Dwr/F3+
involves: 129S1/Sv * 129X1/SvJ 		abnormal blood coagulation J:99260
abnormal thrombosis J:99260
decreased partial thromboplastin time J:99260
increased circulating factor IX level J:99260
increased circulating factor VIII level J:99260
increased circulating factor XI level J:99260
postnatal lethality J:99260
pregnancy-related premature death J:99260
premature death J:99260
F3tm1Dwr/F3tm1Dwr
involves: 129S1/Sv * 129X1/SvJ 		abnormal atrial thrombosis J:99260
abnormal cardiac thrombosis J:99260
abnormal thrombosis J:99260
abnormal ventricular thrombosis J:99260
neonatal lethality, incomplete penetrance J:99260
premature death J:99260
F3tm1Fct/F3tm1Fct
involves: 129P2/OlaHsd * C57BL/6J 		abnormal blood coagulation J:216519
abnormal embryonic erythrocyte morphology J:216519
abnormal extraembryonic mesoderm development J:216519
abnormal vitelline vasculature morphology J:216519
embryonic growth retardation J:216519
embryonic lethality during organogenesis, complete penetrance J:216519
F3tm1Gjb/F3+
involves: 129X1/SvJ * C57BL/6 		abnormal chemokine secretion J:128891
abnormal macrophage physiology J:128891
decreased interleukin-6 secretion J:128891
normal immune system phenotype J:128891
F3tm1Gjb/F3tm1Gjb
involves: 129S6/SvEvTac * 129X1/SvJ 		embryonic lethality during organogenesis, complete penetrance J:41500
F3tm1Gjb/F3tm1Gjb
involves: 129X1/SvJ * C57BL/6 		abnormal forebrain development J:35037
abnormal heart morphology J:35037
ataxia J:41500
blindness J:41500
decreased body weight J:41500
decreased embryo size J:35037
embryonic growth retardation J:35037
embryonic lethality during organogenesis, incomplete penetrance J:35037, J:41500
hemorrhage J:41500
internal hemorrhage J:41500
intracerebral hemorrhage J:41500
pale yolk sac J:35037
pallor J:35037
postnatal lethality, complete penetrance J:41500
prenatal lethality, complete penetrance J:35037
F3tm1Jld/F3+
involves: 129P2/OlaHsd * NIH Black Swiss 		abnormal blood coagulation J:33831
F3tm1Jld/F3tm1Jld
involves: 129P2/OlaHsd * NIH Black Swiss 		abnormal blood vessel physiology J:33831
abnormal embryonic erythrocyte morphology J:33831
abnormal forebrain development J:33831
abnormal vitelline vasculature morphology J:33831
distended pericardium J:33831
embryo tissue necrosis J:33831
embryonic growth retardation J:33831
embryonic lethality during organogenesis, complete penetrance J:33831
enlarged heart J:33831
hemorrhage J:33831
pale yolk sac J:33831
pallor J:33831
F3tm1Nmk/F3tm1Nmk
Myl2tm1(cre)Krc/?
involves: 129S4/SvJae * 129S6/SvEvTac 		cardiac fibrosis J:137921
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
MGI 6.24 		The Jackson Laboratory