Cfh Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cfh
complement component factor h
MGI:88385

66 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cfh^tm1.1Song/Cfh^tm1.1Song involves: C57BL/6	abnormal behavior	J:240426
	abnormal blood coagulation	J:240426
	abnormal blood homeostasis	J:240426
	abnormal brain thrombosis	J:240426
	abnormal glomerular capillary endothelium morphology	J:240426
	abnormal glomerular capillary morphology	J:240426
	abnormal glomerular capillary thrombosis	J:240426
	abnormal glomerular mesangium morphology	J:240426
	abnormal hepatic portal vein thrombosis	J:240426
	abnormal kidney morphology	J:240426
	abnormal kidney thrombosis	J:240426
	abnormal kidney vasculature morphology	J:240426
	abnormal kidney venous thrombosis	J:240426
	abnormal lung thrombosis	J:240426
	abnormal renal glomerulus morphology	J:240426
	abnormal retina morphology	J:240426
	abnormal retina vasculature morphology	J:240426
	abnormal thrombosis	J:240426
	anemia	J:240426
	artery occlusion	J:240426
	brain ischemia	J:240426
	circling	J:240426
	decreased body size	J:240426
	decreased circulating complement protein level	J:240426
	decreased complement C5 level	J:240426
	decreased hemoglobin content	J:240426
	decreased serum complement activity	J:240426
	expanded mesangial matrix	J:240426
	hindlimb paralysis	J:240426
	impaired muscle relaxation	J:240426
	increased blood urea nitrogen level	J:240426
	increased creatine level	J:240426
	increased susceptilbility to retina ischemic injury	J:240426
	intracerebral hemorrhage	J:240426
	premature death	J:240426
	reticulocytosis	J:240426
	retina detachment	J:240426
	thrombocytopenia	J:240426
	white pupil	J:240426
Cfh^{tm1a(EUCOMM)Wtsi}/Cfh^{tm1a(EUCOMM)Wtsi} C57BL/6N-Cfh^{tm1a(EUCOMM)Wtsi}/Wtsi	increased mean corpuscular hemoglobin	J:175295
Cfh^tm1Mbo/Cfh⁺ involves: 129/Sv * C57BL/6	decreased circulating complement protein level	J:78193
Cfh^tm1Mbo/Cfh^tm1Mbo B6.129-Cfh^tm1Mbo	abnormal Bruch membrane morphology	J:125991
	abnormal retina layer morphology	J:125991
	abnormal retina morphology	J:125991, J:203471
	abnormal retina photoreceptor morphology	J:125991
	abnormal retina pigment epithelium morphology	J:125991
	abnormal retina rod bipolar cell morphology	J:125991
	amyloid beta deposits	J:203471
	decreased a-wave amplitude	J:125991
	decreased b-wave amplitude	J:125991
	decreased visual acuity	J:125991
	disorganized photoreceptor outer segment	J:125991
Cfh^tm1Mbo/Cfh^tm1Mbo involves: 129	abnormal complement protein level	J:125860
	decreased circulating complement protein level	J:125860, J:131403
	glomerulonephritis	J:131403
	renal glomerular protein deposits	J:131403
Cfh^tm1Mbo/Cfh^tm1Mbo involves: 129/Sv * C57BL/6	abnormal kidney capillary morphology	J:78193
	abnormal renal glomerulus basement membrane morphology	J:78193
	abnormal renal glomerulus morphology	J:78193
	albuminuria	J:78193
	decreased circulating complement protein level	J:78193
	expanded mesangial matrix	J:78193
	glomerulonephritis	J:78193
	hematuria	J:78193
	increased mesangial cell number	J:78193
	increased susceptibility to type III hypersensitivity reaction	J:78193
	increased urine protein level	J:78193
	mesangial cell interposition	J:78193
	premature death	J:78193
	renal glomerular immunoglobulin deposits	J:78193
	renal glomerular protein deposits	J:78193
Cfh^tm1Mbo/Cfh^tm1Mbo Tg(CAG-Cfh)#Mcp/0 involves: 129/Sv C57BL/6 * CBA	abnormal circulating complement protein level	J:125860
	abnormal complement protein level	J:125860
	abnormal kidney thrombosis	J:125860
	anasarca	J:125860
	hematuria	J:125860
	increased blood urea nitrogen level	J:125860
	kidney failure	J:125860
	premature death	J:125860
	schistocytosis	J:125860
	thrombocytopenia	J:125860

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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