About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cftr
cystic fibrosis transmembrane conductance regulator
MGI:88388
118 phenotypes from 17 alleles in 28 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Cftrem3Cwr/Cftrem3Cwr
C57BL/6J-Cftrem3Cwr/Cwr 		decreased body length J:262928
decreased body weight J:262928
decreased survivor rate J:262928
intestinal obstruction J:262928
premature death J:262928
Cftrtm1.1Cwr/Cftrtm1.1Cwr
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		abnormal intestinal goblet cell morphology J:142723
decreased intestinal epithelial chloride transmembrane transport J:142723
decreased respiratory epithelial chloride transmembrane transport J:142723
intestinal mucus accumulation J:142723
intestinal obstruction J:142723
postnatal growth retardation J:142723
postnatal lethality, incomplete penetrance J:142723
premature death J:142723
Cftrtm1.1Sdw/Cftrtm1.1Sdw
involves: C57BL/6 * C57BL/6J 		abnormal intestinal goblet cell morphology J:323560
decreased physiological sensitivity to xenobiotic J:323560
dilated crypt of Lieberkuhn J:323560
disheveled coat J:323560
intestinal obstruction J:323560
postnatal lethality, incomplete penetrance J:323560
premature death J:323560
normal respiratory system phenotype J:323560
Cftrtm1Cam/Cftrtm1Cam
involves: 129S/SvEv 		abnormal colon morphology J:23850
abnormal crypts of Lieberkuhn morphology J:23850
abnormal intestine morphology J:23850
abnormal lacrimal gland morphology J:23850
abnormal small intestine morphology J:23850
decreased body weight J:23850
decreased respiratory epithelial chloride transmembrane transport J:23850
decreased respiratory epithelial sodium ion transmembrane transport J:23850
dilated crypt of Lieberkuhn J:23850
dilated pancreatic duct J:23850
increased susceptibility to infection J:23850
intestinal mucus accumulation J:23850
intestinal obstruction J:2584, J:23850
meconium ileus J:2584, J:23850
peritoneal inflammation J:23850
postnatal lethality, incomplete penetrance J:2584, J:23850
premature death J:2584, J:23850
normal respiratory system phenotype J:23850
small cecum J:2584
Cftrtm1Cwr/Cftrtm1Cwr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:142723
Cftrtm1Eur/Cftrtm1Eur
B6.129P2-Cftrtm1Eur 		abnormal intestinal goblet cell morphology J:189205
abnormal small intestinal crypt cell physiology J:189205
abnormal small intestine crypts of Lieberkuhn morphology J:189205
Cftrtm1Eur/Cftrtm1Eur
involves: 129P2/OlaHsd * FVB/N 		abnormal gallbladder physiology J:28979
abnormal intestinal goblet cell morphology J:28979
abnormal large intestine crypts of Lieberkuhn morphology J:28979
decreased body weight J:28979
decreased intestinal epithelial chloride transmembrane transport J:28979
decreased respiratory epithelial chloride transmembrane transport J:28979
postnatal growth retardation J:28979
Cftrtm1Hgu/Cftrtm1Hgu
CF/1Ztm 		abnormal ileal goblet cell morphology J:112752
intestinal obstruction J:112752
lethality, incomplete penetrance J:112752
normal reproductive system phenotype J:112752
Cftrtm1Hgu/Cftrtm1Hgu
CF/3Ztm 		abnormal ileal goblet cell morphology J:112752
intestinal obstruction J:112752
lethality, incomplete penetrance J:112752
normal reproductive system phenotype J:112752
Cftrtm1Hgu/Cftrtm1Hgu
involves: 129P2/OlaHsd 		abnormal lung morphology J:24119
increased respiratory mucosa goblet cell number J:24119
increased susceptibility to bacterial infection J:24119
lung inflammation J:24119
normal respiratory system phenotype J:103284
Cftrtm1Hgu/Cftrtm1Hgu
involves: 129P2/OlaHsd * MF1 		abnormal colon morphology J:14614
abnormal vas deferens morphology J:14614
atelectasis J:14614
decreased intestinal epithelial chloride transmembrane transport J:14614
decreased respiratory epithelial chloride transmembrane transport J:14614
meconium ileus J:20037
postnatal lethality, incomplete penetrance J:20037
Cftrtm1Hsc/Cftrtm1Hsc
involves: 129S1/Sv * 129X1/SvJ 		postnatal lethality, complete penetrance J:31759
Cftrtm1Hsc/Cftrtm1Hsc
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ 		abnormal intestine physiology J:102288
postnatal lethality, incomplete penetrance J:31759
Cftrtm1Hsc/Cftrtm1Hsc
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J * DBA/2J 		abnormal intestine physiology J:102288
postnatal lethality, incomplete penetrance J:102288
Cftrtm1Hsc/Cftrtm1Hsc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		postnatal lethality, incomplete penetrance J:31759
Cftrtm1Hsc/Cftrtm1Hsc
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal colon goblet cell morphology J:31759
abnormal crypts of Lieberkuhn morphology J:31759
abnormal intestinal mucosa morphology J:31759
abnormal small intestinal crypt cell physiology J:31759
abnormal small intestine goblet cell morphology J:31759
decreased body size J:31759
increased respiratory epithelial sodium ion transmembrane transport J:31759
intestinal obstruction J:31759
meconium ileus J:31759
postnatal growth retardation J:31759
postnatal lethality, incomplete penetrance J:31759
weight loss J:31759
Cftrtm1Hsc/Cftrtm1Hsc
involves: 129S1/Sv * 129X1/SvJ * DBA/2J 		preweaning lethality, complete penetrance J:31759
Cftrtm1Kth/Cftrtm1Kth
B6.129S7-Cftrtm1Kth 		abnormal uterine cervix morphology J:145380
absent estrous cycle J:145380
decreased corpora lutea number J:145380
decreased litter size J:145380
decreased ovary weight J:145380
decreased ovulation rate J:145380
decreased respiratory epithelial chloride transmembrane transport J:112450
decreased uterus weight J:145380
delayed sexual maturation J:145380
normal homeostasis/metabolism phenotype J:145380
impaired fertilization J:145380
impaired sperm migration in female genital tract J:145380
increased susceptibility to bacterial infection induced morbidity/mortality J:112450
intestinal obstruction J:112450
lung inflammation J:112450
postnatal growth retardation J:112450, J:145380
prolonged estrous cycle J:145380
reduced female fertility J:145380
small ovary J:145380
small uterus J:145380
thin uterus J:145380
Cftrtm1Kth/Cftrtm1Kth
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal digestive system physiology J:29074
abnormal fluid regulation J:29074
abnormal intestine morphology J:29074
abnormal ion homeostasis J:29074
abnormal jejunum morphology J:29074
abnormal pancreas physiology J:29074
decreased body size J:29074
decreased body weight J:29074
dilated Brunner's gland J:29074
intestinal obstruction J:29074
peritoneal inflammation J:29074
postnatal lethality, incomplete penetrance J:29074
Cftrtm1Unc/Cftr+
involves: 129P2/OlaHsd 		asthenozoospermia J:122297
decreased litter size J:122297
impaired fertilization J:122297
impaired sperm capacitation J:122297
reduced male fertility J:122297
Cftrtm1Unc/Cftr+
involves: BALB/cJ * C57BL/6J 		transmission ratio distortion J:125558
Cftrtm1Unc/Cftrtm1Unc
B6.129P2-Cftrtm1Unc 		abnormal bronchus morphology J:44904
abnormal intestine morphology J:44904
abnormal pulmonary alveolus morphology J:44904
decreased respiratory epithelial chloride transmembrane transport J:44904
increased lung compliance J:44904
lung inflammation J:44904
postnatal growth retardation J:44904
postnatal lethality, incomplete penetrance J:44904
pulmonary interstitial fibrosis J:44904
Cftrtm1Unc/Cftrtm1Unc
B6.129P2-Cftrtm1Unc/J 		abnormal phospholipid level J:58571
abnormal uterine cervix morphology J:145380
absent estrous cycle J:145380
decreased body weight J:145380
decreased corpora lutea number J:145380
decreased intestinal epithelial sodium ion transmembrane transport J:32766
decreased litter size J:145380
decreased ovary weight J:145380
decreased ovulation rate J:145380
decreased respiratory epithelial chloride transmembrane transport J:112450
decreased respiratory epithelial sodium ion transmembrane transport J:112450
decreased uterus weight J:145380
delayed sexual maturation J:145380
dilated pancreatic acinus J:58571
normal homeostasis/metabolism phenotype J:145380
ileum hypertrophy J:58571
impaired fertilization J:145380
impaired sperm migration in female genital tract J:145380
increased susceptibility to bacterial infection induced morbidity/mortality J:112450
intestinal obstruction J:112450
lung inflammation J:58571, J:112450
pancreatic acinar cell zymogen granule accumulation J:58571
postnatal growth retardation J:112450
postnatal lethality, incomplete penetrance J:32766
prolonged estrous cycle J:145380
reduced female fertility J:145380
small ovary J:145380
small uterus J:145380
thin uterus J:145380
Cftrtm1Unc/Cftrtm1Unc
involves: 129P2/OlaHsd 		abnormal Brunner's gland morphology J:2079
abnormal colon morphology J:2079
abnormal crypts of Lieberkuhn morphology J:2079
abnormal gait J:2079
abnormal gallbladder morphology J:2079
abnormal gland morphology J:2079
abnormal intestine morphology J:2079
abnormal nasal mucosa morphology J:2079
abnormal pancreas morphology J:2079
abnormal paranasal sinus morphology J:2079
abnormal submandibular gland morphology J:2079
abnormal thymus involution J:2079
abnormal trachea gland morphology J:2079
abnormal trachea morphology J:2079
coiled cecum J:2079
decreased body size J:2079
dilated gallbladder J:2079
distended abdomen J:2079
female infertility J:2079
increased respiratory mucosa goblet cell number J:2079
intestinal obstruction J:2079
peritoneal inflammation J:2079
postnatal lethality, incomplete penetrance J:2079
premature death J:2079
small pancreas J:2079
spleen hyperplasia J:2079
Cftrtm1Unc/Cftrtm1Unc
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal intestinal goblet cell morphology J:21934
coiled cecum J:21934
decreased intestinal epithelial chloride transmembrane transport J:21934
dilated crypt of Lieberkuhn J:21934
postnatal lethality, incomplete penetrance J:21934
Cftrtm1Unc/Cftrtm1Unc
involves: 129P2/OlaHsd * C57BL/6J 		abnormal vital capacity J:44904
decreased respiratory epithelial chloride transmembrane transport J:44904
postnatal growth retardation J:44904
postnatal lethality, incomplete penetrance J:44904
normal respiratory system phenotype J:44904
Cftrtm2Cam/Cftrtm2Cam
involves: 129S/SvEv 		abnormal intestine physiology J:27734
abnormal large intestine crypts of Lieberkuhn morphology J:27734
abnormal small intestine crypts of Lieberkuhn morphology J:27734
decreased respiratory epithelial chloride transmembrane transport J:27734
normal endocrine/exocrine gland phenotype J:27734
intestinal obstruction J:27734
meconium ileus J:27734
peritoneal inflammation J:27734
postnatal lethality, incomplete penetrance J:27734
premature death J:27734
normal respiratory system phenotype J:27734
Cftrtm2Hgu/Cftrtm2Hgu
involves: 129P2/OlaHsd * C57BL/6 		abnormal digestive system physiology J:74740
abnormal intestinal goblet cell morphology J:74740
abnormal respiratory system physiology J:74740
normal craniofacial phenotype J:74740
normal reproductive system phenotype J:74740
Cftrtm2Kth/Cftrtm2Kth
involves: 129S7/SvEvBrd * C57BL/6J 		no abnormal phenotype detected J:29074
Cftrtm2Mrc/Cftrtm2Mrc
B6.129S6-Cftrtm2Mrc 		abnormal alveolar macrophage morphology J:112450
decreased neutrophil cell number J:112450
decreased respiratory epithelial chloride transmembrane transport J:112450
normal digestive/alimentary phenotype J:112450
increased susceptibility to bacterial infection induced morbidity/mortality J:112450
lung inflammation J:112450
postnatal growth retardation J:112450
Cftrtm3Bay/Cftrtm3Bay
involves: 129S7/SvEvBrd 		abnormal crypts of Lieberkuhn morphology J:29656
abnormal digestive system physiology J:29656
abnormal pancreas morphology J:29656
decreased body size J:29656
female infertility J:29656
intestinal obstruction J:29656
normal liver/biliary system phenotype J:29656
premature death J:29656
normal respiratory system phenotype J:29656
Cftrtm3Hgu/Cftrtm3Hgu
involves: 129P2/OlaHsd 		abnormal bile duct morphology J:32766
abnormal hepatocyte morphology J:32766
abnormal intestinal mucosa morphology J:32766
abnormal salivary gland morphology J:32766
abnormal submucosal gland morphology J:32766
bile duct epithelium hyperplasia J:32766
decreased body size J:32766
decreased body weight J:32766
decreased intestinal epithelial sodium ion transmembrane transport J:32766
decreased respiratory epithelial chloride transmembrane transport J:32766
decreased respiratory epithelial sodium ion transmembrane transport J:32766
decreased small intestinal villus number J:32766
dilated crypt of Lieberkuhn J:32766
normal endocrine/exocrine gland phenotype J:32766
enlarged gallbladder J:32766
gallbladder inflammation J:32766
intestinal obstruction J:32766
peritoneal inflammation J:32766
postnatal lethality, incomplete penetrance J:32766
normal reproductive system phenotype J:32766
normal respiratory system phenotype J:32766
Cftrtm3Mrc/Cftrtm3Mrc
B6.129S6-Cftrtm3Mrc 		decreased respiratory epithelial chloride transmembrane transport J:112450
increased susceptibility to bacterial infection induced morbidity/mortality J:112450
intestinal obstruction J:112450
lung inflammation J:112450
postnatal growth retardation J:112450
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory