Cftr Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cftr
cystic fibrosis transmembrane conductance regulator
MGI:88388

33 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cfmq1^129X1/SvJ/Cfmq1^C57BL/6J Cftr^tm1Unc/Cftr^tm1Unc involves: 129X1/SvJ * C57BL/6J	abnormal crypts of Lieberkuhn morphology	J:101842
	decreased body weight	J:101842
	intestinal inflammation	J:101842
	normal mortality/aging	J:101842
Cfmq2^129X1/SvJ/Cfmq2^129X1/SvJ Cftr^tm1Unc/Cftr^tm1Unc involves: 129X1/SvJ * C57BL/6J	abnormal crypts of Lieberkuhn morphology	J:101842
	decreased body weight	J:101842
	intestinal inflammation	J:101842
	normal mortality/aging	J:101842
Cfmq3^129X1/SvJ/Cfmq3^C57BL/6J Cftr^tm1Unc/Cftr^tm1Unc involves: 129X1/SvJ * C57BL/6J	abnormal crypts of Lieberkuhn morphology	J:101842
	decreased body weight	J:101842
	intestinal inflammation	J:101842
	normal mortality/aging	J:101842
Cftr^tm1Bay/Cftr^tm1Bay involves: 129S7/SvEvBrd * C57BL/6J	abnormal colon morphology	J:15244
	abnormal gland morphology	J:15244
	abnormal intestinal goblet cell morphology	J:15244
	abnormal intestine morphology	J:15244
	acute pancreas inflammation	J:15244
	aphagia	J:15244
	cachexia	J:15244
	crypts of Lieberkuhn abscesses	J:15244
	decreased intestinal epithelial chloride transmembrane transport	J:15244
	decreased respiratory epithelial chloride transmembrane transport	J:15244
	dilated crypt of Lieberkuhn	J:15244
	distended abdomen	J:15244
	enlarged gallbladder	J:15244
	intestinal mucus accumulation	J:15244
	intestinal obstruction	J:15244
	intestinal ulcer	J:15244
	lacrimal gland atrophy	J:15244
	pancreatic acinar cell atrophy	J:15244
	postnatal growth retardation	J:15244
	postnatal lethality, incomplete penetrance	J:15244
	weight loss	J:15244
Cftr^tm1Eur/Cftr^tm1Eur Nherf1^tm1Ssl/Nherf1^tm1Ssl involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	abnormal physiological response to xenobiotic	J:128912
Cftr^tm1Unc/Cftr⁺ Tmrdq1^BALB/cJ/Tmrdq1^BALB/cJ involves: BALB/cJ * C57BL/6J	transmission ratio distortion	J:125558
Cftr^tm1Unc/Cftr^tm1Unc Tg(FABPCFTR)1Jaw/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal alveolar macrophage physiology	J:129519
	abnormal cecum morphology	J:21934
	abnormal colon goblet cell morphology	J:21934
	decreased intestinal epithelial chloride transmembrane transport	J:21934
	normal mortality/aging	J:21934
Cftr^tm1Unc/Cftr^tm1Unc Tg(FABPCFTR)1Jaw/0 Tg(Scgb1a1-Scnn1b)6608Bouc/0 involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N	abnormal mucociliary clearance	J:191673
	postnatal lethality, incomplete penetrance	J:191673
	pulmonary epithelial necrosis	J:191673
	respiratory system inflammation	J:191673

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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