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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Chat
choline O-acetyltransferase
MGI:88392
51 phenotypes from 9 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Chat/Slc18a3tm1.1Vpra/Chat+
involves: 129S4/SvJae * C57BL/6J 		abnormal miniature endplate potential J:171696
normal behavior/neurological phenotype J:171696
increased acetylcholine level J:153908
Chat/Slc18a3tm1.1Vpra/Chat/Slc18a3tm1.1Vpra
involves: 129S4/SvJae * C57BL/6J 		abnormal miniature endplate potential J:153908
abnormal motor neuron innervation pattern J:153908
abnormal neuromuscular synapse morphology J:153908
abnormal skeletal muscle morphology J:153908
abnormal synaptic acetylcholine release J:153908
cyanosis J:153908
hypotonia J:153908
increased acetylcholine level J:153908
increased motor neuron number J:153908
kyphosis J:153908
neonatal lethality, complete penetrance J:153908
skeletal muscle atrophy J:153908
skeletal muscle fiber atrophy J:153908
Chat/Slc18a3tm1.1Vpra/Chat/Slc18a3tm1.1Vpra
Tg(Chat-COP4*H134R/EYFP,Slc18a3)6Gfng/0
involves: 129S4/SvJae * C57BL/6 * CBA 		normal mortality/aging J:197166
Chat/Slc18a3tm1.2Vpra/Chat/Slc18a3tm1.2Vpra
involves: 129S4/SvJae * C57BL/6J 		normal behavior/neurological phenotype J:171696
Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1.1Vpra
involves: 129S4/SvJae * C57BL/6J 		abnormal miniature endplate potential J:171696
normal behavior/neurological phenotype J:171696
hyperactivity J:171696
increased vertical activity J:171696
Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1Vpra
involves: 129S4/SvJae * C57BL/6J 		abnormal miniature endplate potential J:171696
normal behavior/neurological phenotype J:171696
hyperactivity J:171696
Chattm1(cre)Lowl/Chat+
involves: 129S6/SvEvTac * C57BL/6 		no abnormal phenotype detected J:114556
Chattm1(cre/ERT)Nat/Chattm1(cre/ERT)Nat
involves: 129 * C57BL/6 		no abnormal phenotype detected J:144315
Chattm1.1Jrs/Chattm1.1Jrs
Not Specified 		abnormal innervation pattern to muscle J:91066
abnormal muscle morphology J:91066
abnormal neuromuscular synapse morphology J:91066
abnormal phrenic nerve morphology J:91066
abnormal Schwann cell morphology J:91066
carpoptosis J:91066
diaphragmatic hernia J:91066
increased motor neuron number J:91066
kyphosis J:91066
neonatal lethality, complete penetrance J:91066
thin diaphragm muscle J:91066
Chattm1Fhg/Chattm1Fhg
involves: 129S2/SvPas * C57BL/6 		abnormal innervation J:81738
abnormal neuromuscular synapse morphology J:81738
abnormal PNS synaptic transmission J:81738
carpoptosis J:81738
decreased fetal size J:81738
increased motor neuron number J:81738
kyphosis J:81738
perinatal lethality, complete penetrance J:81738
normal reproductive system phenotype J:113236
Chattm1Fhg/Chattm1Fhg
involves: 129S4/SvJae 		increased motor neuron number J:161300
Chattm1Jrs/Chattm1Jrs
Tg(CAG-cre/Esr1*)1Lbe/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal innervation pattern to muscle J:89596
postnatal lethality, complete penetrance J:89596
weakness J:89596
Chattm1Jrs/Chattm1Jrs
Tg(CAG-cre/Esr1*)1Lbe/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal axon morphology J:89596
abnormal neuromuscular synapse morphology J:89596
postnatal lethality, complete penetrance J:89596
weakness J:89596
Chattm1Mlt/Chattm1Mlt
Tg(SLC18A3-cre)KMisa/0
involves: 129 * C57BL/6 		abnormal gait J:212048
abnormal gastrocnemius morphology J:212048
abnormal habituation to a new environment J:212048
abnormal muscle morphology J:212048
abnormal soleus morphology J:212048
abnormal tail morphology J:212048
cornea opacity J:212048
decreased body weight J:212048
decreased locomotor activity J:212048
decreased vertical activity J:212048
kyphosis J:212048
muscle weakness J:212048
muscular atrophy J:212048
normal nervous system phenotype J:212048
premature death J:212048
rectal prolapse J:212048
skeletal muscle endomysial fibrosis J:212048
skeletal muscle fibrosis J:212048
tail dragging J:212048
tremors J:212048
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory