Chrm1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chrm1
cholinergic receptor, muscarinic 1, CNS
MGI:88396

19 phenotypes from 5 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Chrm1^tm1Jwe/Chrm1^tm1Jwe involves: 129S6/SvEvTac * CF-1	abnormal nervous system electrophysiology	J:74588
	decreased cytotoxic T cell cytolysis	J:106393
	increased bronchoconstrictive response	J:104034
	normal nervous system phenotype	J:112505
Chrm1^tm1Kano/Chrm1^tm1Kano involves: 129X1/SvJ	normal endocrine/exocrine gland phenotype	J:105126
Chrm1^tm1Kano/Chrm1^tm1Kano involves: 129X1/SvJ * C57BL/6	abnormal inhibitory postsynaptic currents	J:98902
Chrm1^tm1Kano/Chrm1^tm1Kano involves: 129X1/SvJ * C57BL/6J	normal digestive/alimentary phenotype	J:104782
Chrm1^tm1Nmn/Chrm1^tm1Nmn B6.129X1-Chrm1^tm1Nmn	abnormal auditory cortex morphology	J:96239
	abnormal auditory cortex tonotopy	J:96239
	abnormal CNS synapse formation	J:96239
	normal hearing/vestibular/ear phenotype	J:96239
Chrm1^tm1Stl/Chrm1⁺ C57BL/6-Chrm1^tm1Stl	increased locomotor activity	J:73448
Chrm1^tm1Stl/Chrm1^tm1Stl C57BL/6-Chrm1^tm1Stl	increased dopamine level	J:73448
Chrm1^tm1Stl/Chrm1^tm1Stl C57BL/6-Chrm1^tm1Stl	increased locomotor activity	J:73448
Chrm1^tm1Stl/Chrm1^tm1Stl involves: C57BL/6	abnormal excitatory postsynaptic potential	J:112782
	decreased paired-pulse facilitation	J:112782
	reduced long-term depression	J:112782
Chrm1^tm2.1Stl/Chrm1^tm2.1Stl Emx1^{tm1.1(cre)Ito}/0 involves: 129P2/OlaHsd	abnormal excitatory postsynaptic currents	J:156540
	abnormal long-term depression	J:156540
	abnormal miniature excitatory postsynaptic currents	J:156540
	decreased paired-pulse facilitation	J:156540
Chrm1^tm2.1Stl/Chrm1^tm2.1Stl Tg(Grik4-cre)G32-4Stl/0 involves: 129P2/OlaHsd * C57BL/6	abnormal excitatory postsynaptic currents	J:156540
	abnormal long-term depression	J:156540
	decreased paired-pulse facilitation	J:156540

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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