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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Chrm3
cholinergic receptor, muscarinic 3, cardiac
MGI:88398
49 phenotypes from 7 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Chrm3mpc214H/Chrm3mpc214H
involves: BALB/c * C3H/HeH * C57BL/6J 		impaired pupillary reflex J:234901
Chrm3tm1Abt/Chrm3tm1Abt
involves: 129X1/SvJ * C57BL/6 		normal behavior/neurological phenotype J:160283
impaired contextual conditioning behavior J:160283
impaired cued conditioning behavior J:160283
Chrm3tm1Jwe/Chrm3+
involves: 129S6/SvEvTac * C57BL/6J 		decreased circulating insulin level J:91888
decreased insulin secretion J:91888
Chrm3tm1Jwe/Chrm3tm1Jwe
129S6/SvEvTac-Chrm3tm1Jwe 		decreased body weight J:67919
decreased gonadal fat pad weight J:67919
Chrm3tm1Jwe/Chrm3tm1Jwe
involves: 129S6/SvEvTac 		abnormal digestive system physiology J:113518
abnormal respiratory system physiology J:113518
abnormal urinary bladder physiology J:113518
normal cardiovascular system phenotype J:113518
decreased body weight J:113518
impaired smooth muscle contractility J:113518
Chrm3tm1Jwe/Chrm3tm1Jwe
involves: 129S6/SvEvTac * C57BL/6J 		abnormal glucose homeostasis J:67919
decreased body temperature J:67919
decreased body weight J:67919, J:91888
decreased circulating glucagon level J:91888
decreased circulating glucose level J:91888
decreased circulating insulin level J:67919, J:91888
decreased circulating leptin level J:67919
decreased circulating triglyceride level J:67919
decreased food intake J:67919
decreased glucagon secretion J:91888
decreased gonadal fat pad weight J:67919
decreased insulin secretion J:91888
improved glucose tolerance J:91888
increased insulin sensitivity J:67919
weight loss J:67919
Chrm3tm1Jwe/Chrm3tm1Jwe
involves: 129S6/SvEvTac * CF-1 		abnormal brain wave pattern J:103891
abnormal frequency of paradoxical sleep J:103891
abnormal gallbladder physiology J:125455
normal behavior/neurological phenotype J:160283
decreased bronchoconstrictive response J:104034
decreased vasodilation J:102321
impaired contextual conditioning behavior J:160283
impaired cued conditioning behavior J:160283
impaired smooth muscle contractility J:125455
normal nervous system phenotype J:112505
Chrm3tm1Mmt/Chrm3tm1Mmt
B6.129X1-Chrm3tm1Mmt 		abnormal histamine physiology J:104782
decreased digestive secretion J:104782
Chrm3tm1Mmt/Chrm3tm1Mmt
involves: 129X1/SvJ 		abnormal inhibitory postsynaptic currents J:98902
abnormal submandibular gland physiology J:105126
decreased salivation J:105126
impaired contractility of ileal smooth muscle J:99247
impaired smooth muscle contractility J:99247
increased fluid intake J:105126
mydriasis J:99247
Chrm3tm1Mmt/Chrm3tm1Mmt
involves: 129X1/SvJ * C57BL/6 		abnormal urinary bladder morphology J:64069
decreased body size J:64069
decreased body weight J:64069
decreased salivation J:64069
distended urinary bladder J:64069
hydronephrosis J:64069
impaired contractility of ileal smooth muscle J:64069
impaired contractility of urinary bladder detrusor smooth muscle J:64069
mydriasis J:64069
Chrm3tm2.1Jwe/Chrm3tm2.1Jwe
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N 		decreased circulating glucose level J:158245
normal growth/size/body region phenotype J:158245
normal homeostasis/metabolism phenotype J:158245
Chrm3tm2Jwe/Chrm3tm2Jwe
Tg(Ins2-cre)25Mgn/0
involves: 129S6/SvEvTac * C57BL/6 * DBA 		decreased insulin secretion J:129643
impaired glucose tolerance J:129643
Tg(Ins2-Chrm3*)1Jwe/0
involves: C57BL/6 		abnormal glucose homeostasis J:129643
normal growth/size/body region phenotype J:158245
normal homeostasis/metabolism phenotype J:158245
hypoglycemia J:129643
improved glucose tolerance J:129643
increased circulating insulin level J:129643
increased insulin secretion J:129643
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12/10/2024
MGI 6.24 		The Jackson Laboratory