Chrm4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chrm4
cholinergic receptor, muscarinic 4
MGI:88399

20 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Chrm4^{tm1b(EUCOMM)Hmgu}/Chrm4^{tm1b(EUCOMM)Hmgu} B6N(Cg)-Chrm4^{tm1b(EUCOMM)Hmgu}/J	hyperactivity	J:211773
	increased startle reflex	J:211773
Chrm4^tm1Jwe/Chrm4^tm1Jwe B6.129S6-Chrm4^tm1Jwe	abnormal vocalization	J:134260
Chrm4^tm1Jwe/Chrm4^tm1Jwe involves: 129S6/SvEvTac * CF-1	abnormal CNS synaptic transmission	J:112505
	abnormal gallbladder physiology	J:125455
	abnormal heart rate	J:60451
	decreased body weight	J:57480
	normal homeostasis/metabolism phenotype	J:57480
	impaired smooth muscle contractility	J:125455
	increased locomotor activity	J:57480
	normal muscle phenotype	J:60451
Chrm4^tm1Minm/Chrm4^tm1Minm involves: 129X1/SvJ * DBA/2J	abnormal behavioral response to xenobiotic	J:99248
Chrm4^tm1Minm/Chrm4^tm1Minm involves: 129X1/SvJ * DBA/2J	abnormal locomotor behavior	J:99248
Chrm4^tm2.1Jwe/Chrm4^tm2.1Jwe Tg(Drd1a-cre)AGsc/0 involves: 129S6/SvEvTac * C57BL/6 * FVB/N	abnormal neuron physiology	J:157841
	catalepsy	J:157841
	enhanced behavioral response to addictive substance	J:157841
	enhanced behavioral response to cocaine	J:157841
	enhanced behavioral response to xenobiotic	J:157841
	hyperactivity	J:157841
	impaired behavioral response to xenobiotic	J:157841
	increased dopamine level	J:157841

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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