Cntf Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cntf
ciliary neurotrophic factor
MGI:88439

19 phenotypes from 3 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cntf^tm1Gdy/Cntf^tm1Gdy involves: 129P2/OlaHsd * C57BL/6	abnormal motor neuron morphology	J:66057
Cntf^tm1Gdy/Cntf^tm1Gdy involves: 129P2/OlaHsd * C57BL/6	normal nervous system phenotype	J:29357
Cntf^tm1Mpin/Cntf^tm1Mpin B6.129S2-Cntf^tm1Mpin	abnormal myelin sheath morphology	J:126852
	abnormal oligodendrocyte apoptosis	J:126852
	axon degeneration	J:126852
	decreased oligodendrocyte progenitor number	J:126852
	increased susceptibility to experimental autoimmune encephalomyelitis	J:126852
Cntf^tm1Mpin/Cntf^tm1Mpin involves: 129S2/SvPas	abnormal microglial cell morphology	J:15313
	abnormal motor neuron morphology	J:15313
	decreased grip strength	J:15313
	decreased motor neuron number	J:15313
	motor neuron degeneration	J:15313
	muscle weakness	J:15313
Cntf^tm1Mpin/Cntf^tm1Mpin involves: 129S2/SvPas * C57BL/6	abnormal astrocyte physiology	J:84375
	abnormal axon extension	J:158286
	increased susceptibility to injury	J:84375, J:158286
	normal nervous system phenotype	J:141582
Cntf^tm1Vlcg/Cntf^tm1Vlcg B6.Cg-Cntf^tm1Vlcg	astrocytosis	J:185957
Cntf^tm1Vlcg/Cntf^tm1Vlcg B6.Cg-Cntf^tm1Vlcg	increased cerebral infarct size	J:185957
Cntf^tm1Vlcg/Cntf^tm1Vlcg involves: 129S6/SvEvTac * C57BL/6NTac	abnormal neuron proliferation	J:186611
	decreased neuronal precursor cell number	J:186611
	normal nervous system phenotype	J:186611

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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