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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Col10a1
collagen, type X, alpha 1
MGI:88445
57 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Col10a1tm1.1Rpbh/Col10a1+
involves: 129 * C57BL/6 		increased width of hypertrophic chondrocyte zone J:154052
short femur J:154052
Col10a1tm1.1Rpbh/Col10a1tm1.1Rpbh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cell morphology J:154052
abnormal pelvic girdle bone morphology J:154052
decreased osteoclast cell number J:154052
disproportionate dwarf J:154052
increased endoplasmic reticulum stress J:154052
increased width of hypertrophic chondrocyte zone J:154052
short femur J:154052
slow postnatal weight gain J:154052
Col10a1tm1Bhr/Col10a1tm1Bhr
involves: 129S7/SvEvBrd * C57BL/6 		abnormal bone marrow morphology J:62230
abnormal cervical axis morphology J:20879
abnormal long bone epiphyseal plate morphology J:62230
abnormal long bone epiphyseal plate proliferative zone J:62230
abnormal proerythroblast morphology J:62230
abnormal spleen morphology J:62230
abnormal tooth development J:62230
abnormal trabecular bone morphology J:62230
absent lymph nodes J:62230
cachexia J:62230
decreased B cell number J:62230
decreased body weight J:62230
decreased double-positive T cell number J:62230
decreased spleen red pulp amount J:62230
decreased spleen weight J:62230
decreased thymocyte number J:62230
decreased thymus weight J:62230
hydrocephaly J:62230
increased CD4-positive, alpha-beta T cell number J:62230
increased double-negative T cell number J:62230
increased single-positive T cell number J:62230
kyphosis J:62230
lethargy J:62230
lordosis J:62230
postnatal lethality, incomplete penetrance J:62230
premature death J:62230
normal skeleton phenotype J:20879
small spleen J:62230
small thymus J:62230
spleen hypoplasia J:62230
thymus hypoplasia J:62230
Col10a1tm1Ksec/Col10a1tm1Ksec
129/Sv-Col10a1tm1Ksec 		abnormal long bone epiphyseal plate morphology J:38124
abnormal trabecular bone morphology J:38124
coxa vara J:38124
decreased bone mineral content J:38124
Col10a1tm1Ksec/Col10a1tm1Ksec
involves: 129S/SvEv * C57BL/6 		abnormal cartilage morphology J:38124
abnormal femur morphology J:193886
abnormal long bone epiphyseal plate morphology J:38124
abnormal T-helper 2 cell differentiation J:193886
abnormal trabecular bone morphology J:38124
coxa vara J:38124
decreased bone mass J:38124
decreased bone mineral content J:193886
decreased bone mineral density of femur J:193886
decreased dendritic cell number J:193886
decreased interleukin-2 secretion J:193886
decreased interleukin-4 secretion J:193886
decreased interleukin-10 secretion J:193886
decreased interleukin-17 secretion J:193886
increased B cell number J:193886
increased interleukin-4 secretion J:193886
increased T-helper cell number J:193886
increased width of hypertrophic chondrocyte zone J:193886
Col10a1tm2.1Rpbh/Col10a1+
involves: C57BL/6NTac 		abnormal chondrocyte differentiation J:267200
abnormal endochondral bone ossification J:267200
abnormal pelvic girdle bone morphology J:267200
decreased body weight J:267200
disproportionate dwarf J:267200
increased endoplasmic reticulum stress J:267200
increased width of hypertrophic chondrocyte zone J:267200
postnatal growth retardation J:267200
Col10a1tm2.1Rpbh/Col10a1tm2.1Rpbh
involves: C57BL/6NTac 		abnormal chondrocyte differentiation J:267200
abnormal endochondral bone ossification J:267200
abnormal pelvic girdle bone morphology J:267200
decreased body weight J:267200
disproportionate dwarf J:267200
increased endoplasmic reticulum stress J:267200
increased width of hypertrophic chondrocyte zone J:267200
postnatal growth retardation J:267200
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory