Col8a2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Col8a2
collagen, type VIII, alpha 2
MGI:88464

14 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Col8a2^Aca23/Col8a2⁺ C57BL/6J-Col8a2^Aca23	abnormal cornea epithelium morphology	J:158259
	abnormal eye anterior chamber morphology	J:158259
	abnormal eye morphology	J:158259
	decreased cornea stroma thickness	J:158259
	decreased cornea thickness	J:158259
	decreased Descemet membrane thickness	J:158259
	enlarged eye anterior chamber	J:158259
	normal vision/eye phenotype	J:158259
Col8a2^Aca23/Col8a2^Aca23 C57BL/6J-Col8a2^Aca23	abnormal cornea epithelium morphology	J:158259
	abnormal eye anterior chamber morphology	J:158259
	abnormal eye morphology	J:158259
	decreased cornea stroma thickness	J:158259
	decreased cornea thickness	J:158259
	decreased Descemet membrane thickness	J:158259
	enlarged eye anterior chamber	J:158259
	normal vision/eye phenotype	J:158259
Col8a2^tm1.1Asj/Col8a2^tm1.1Asj involves: 129S6/SvEvTac	abnormal autophagy	J:214908
	abnormal cornea endothelium morphology	J:214908
	abnormal Descemet membrane morphology	J:214908
	abnormal endoplasmic reticulum morphology	J:214908
Col8a2^tm1.1Asj/Col8a2^tm1.1Asj involves: 129S6/SvEvTac * C57BL/6 * CBA	abnormal cornea endothelium morphology	J:179022
	abnormal Descemet membrane morphology	J:179022
	abnormal endoplasmic reticulum morphology	J:179022
	abnormal mitochondrial morphology	J:179022
	increased apoptosis	J:179022
Col8a2^tm1Bjro/Col8a2^tm1Bjro B6.129S4-Col8a2^tm1Bjro	abnormal Descemet membrane morphology	J:100136
Col8a2^tm1Bjro/Col8a2^tm1Bjro B6.129S4-Col8a2^tm1Bjro	decreased Descemet membrane thickness	J:100136
Col8a2^tm2.1Asj/Col8a2^tm2.1Asj involves: 129S6/SvEvTac * C57BL/6 * CBA	abnormal autophagy	J:214908
	abnormal cornea endothelium morphology	J:214908
	abnormal Descemet membrane morphology	J:214908
	abnormal endoplasmic reticulum morphology	J:214908

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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