Col1a2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Col1a2
collagen, type I, alpha 2
MGI:88468

52 phenotypes from 4 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Col1a2^oim/Col1a2⁺ B6C3Fe a/a-Col1a2^oim/J	abnormal compact bone morphology	J:38013
Col1a2^oim/Col1a2⁺ B6C3Fe a/a-Col1a2^oim/J	decreased bone strength	J:38013
Col1a2^oim/Col1a2^oim B6C3Fe a/a-Col1a2^oim/J	abnormal compact bone lamellar structure	J:38013
	abnormal compact bone morphology	J:38013
	abnormal skin morphology	J:124000
	abnormal tendon morphology	J:124000
	normal cellular phenotype	J:124000
	decreased bone strength	J:38013
Col1a2^oim/Col1a2^oim involves: C3H/HeJ * C57BL/6JLe	abnormal bone mineralization	J:31692
	abnormal caudal vertebrae morphology	J:4348
	abnormal compact bone lamellar structure	J:4348
	abnormal dermal layer morphology	J:4348
	abnormal forelimb morphology	J:4348
	abnormal gait	J:4348
	abnormal joint morphology	J:4348
	abnormal knee joint morphology	J:4348
	abnormal long bone morphology	J:4348, J:31692
	abnormal skin morphology	J:4348
	camptomelia	J:4348
	decreased body size	J:4348
	decreased bone mineral density	J:4348
	decreased bone trabecula number	J:4348
	decreased compact bone thickness	J:4348, J:31692
	decreased tendon stiffness	J:41509
	fragile skeleton	J:4348, J:31692
	hemorrhage	J:4348
	increased osteocyte number	J:4348
	kyphosis	J:4348
	scoliosis	J:4348
Col1a2^tm1.1Mcbr/Col1a2⁺ (A/J x B6.129-Col1a2^tm1.1Mcbr)F1	decreased body weight	J:178743
	decreased bone mineral content	J:178743
	decreased bone strength	J:178743
	decreased bone trabecula number	J:178743
	decreased bone volume	J:178743
	decreased compact bone area	J:178743
	decreased compact bone thickness	J:178743
	increased bone mineral density	J:178743
	increased volumetric bone mineral density	J:178743
Col1a2^tm1.1Mcbr/Col1a2⁺ (BALB/cByJ x B6.129-Col1a2^tm1.1Mcbr)F1	decreased body weight	J:178743
	decreased bone mineral content	J:178743
	decreased bone strength	J:178743
	decreased bone trabecula number	J:178743
	decreased bone volume	J:178743
	decreased compact bone area	J:178743
	decreased compact bone thickness	J:178743
	increased bone mineral density	J:178743
	increased volumetric bone mineral density	J:178743
Col1a2^tm1.1Mcbr/Col1a2⁺ (C3H/HeJ x B6.129-Col1a2^tm1.1Mcbr)F1	decreased body weight	J:178743
	decreased bone mineral content	J:178743
	decreased bone strength	J:178743
	decreased bone trabecula number	J:178743
	decreased bone volume	J:178743
	decreased compact bone area	J:178743
	decreased compact bone thickness	J:178743
	increased bone mineral density	J:178743
	increased volumetric bone mineral density	J:178743
Col1a2^tm1.1Mcbr/Col1a2⁺ (FVB/NJ x B6.129-Col1a2^tm1.1Mcbr)F1	decreased body weight	J:178743
	decreased bone mineral content	J:178743
	decreased bone strength	J:178743
	decreased bone trabecula number	J:178743
	decreased bone volume	J:178743
	increased bone mineral density	J:178743
	increased volumetric bone mineral density	J:178743
Col1a2^tm1.1Mcbr/Col1a2⁺ B6.129(Cg)-Col1a2^tm1.1Mcbr	decreased body weight	J:121691
Col1a2^tm1.1Mcbr/Col1a2^tm1.1Mcbr B6.129(Cg)-Col1a2^tm1.1Mcbr	perinatal lethality, complete penetrance	J:178743
	preweaning lethality, complete penetrance	J:121691
Col1a2^{tm1b(EUCOMM)Wtsi}/Col1a2^{tm1b(EUCOMM)Wtsi} C57BL/6N-Col1a2^{tm1b(EUCOMM)Wtsi}/Bay	abnormal femur morphology	J:211773
	abnormal tibia morphology	J:211773
	decreased blood urea nitrogen level	J:211773
	decreased total body fat amount	J:211773
	dilated heart left ventricle	J:211773
	increased bone mineral content	J:211773
	increased bone mineral density	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased heart weight	J:211773
Col1a2^{tm1b(EUCOMM)Wtsi}/Col1a2^{tm1b(EUCOMM)Wtsi} C57BL/6N-Col1a2^{tm1b(EUCOMM)Wtsi}/BayMmucd	abnormal optic disk morphology	J:211773
	decreased circulating amylase level	J:211773
	decreased grip strength	J:211773
	decreased lymphocyte cell number	J:211773
	decreased mean platelet volume	J:211773
	enlarged heart	J:211773
	enlarged spleen	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased large unstained cell number	J:211773
	increased leukocyte cell number	J:211773
	increased neutrophil cell number	J:211773
Col1a2^tm1Mcbr/Col1a2^tm1Mcbr involves: 129/SvEv * C57BL/6	no abnormal phenotype detected	J:178743

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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