Comt Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Comt
catechol-O-methyltransferase
MGI:88470

41 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Comt^B2i/Comt⁺ Boulder heterogeneous stock	abnormal response to novel object	J:162759
Comt^B2i/Comt⁺ Boulder heterogeneous stock	normal behavior/neurological phenotype	J:162759
Comt^B2i/Comt^B2i Boulder heterogeneous stock	abnormal response to novel object	J:162759
Comt^B2i/Comt^B2i Boulder heterogeneous stock	normal behavior/neurological phenotype	J:162759
Comt^tm1.1Tunb/Comt^tm1.1Tunb B6J.129-Comt^tm1.1Tunb	abnormal cognition	J:269121
	abnormal impulsive behavior control	J:269121
	abnormal spatial working memory	J:269121
	normal behavior/neurological phenotype	J:269121
	cognitive inflexibility	J:269121
Comt^{tm1b(EUCOMM)Wtsi}/Comt^{tm1b(EUCOMM)Wtsi} C57BL/6N-Comt^{tm1b(EUCOMM)Wtsi}/H	abnormal behavior	J:211773
	abnormal locomotor behavior	J:211773
	decreased anxiety-related response	J:211773
	decreased circulating fructosamine level	J:211773
	decreased circulating serum albumin level	J:211773
	decreased circulating total protein level	J:211773
	decreased erythrocyte cell number	J:211773
	decreased hemoglobin content	J:211773
	decreased thigmotaxis	J:211773
	hyperactivity	J:211773
	increased circulating alanine transaminase level	J:211773
	increased circulating phosphate level	J:211773
	increased grip strength	J:211773
Comt^tm1Kara/Comt⁺ involves: 129S4/SvJaeSor	increased aggression towards male mice	J:49475
Comt^tm1Kara/Comt^tm1Kara B6.129S4-Comt^tm1Kara	abnormal xenobiotic pharmacokinetics	J:164057
Comt^tm1Kara/Comt^tm1Kara B6.129S4-Comt^tm1Kara	increased dopamine level	J:164057
Comt^tm1Kara/Comt^tm1Kara involves: 129S4/SvJaeSor	abnormal blood homeostasis	J:137276
	abnormal fertility/fecundity	J:137276
	abnormal homeostasis	J:137276
	abnormal maternal decidual layer morphology	J:137276
	abnormal placenta morphology	J:137276
	abnormal placenta vasculature	J:137276
	abnormal pregnancy	J:137276
	abnormal renal glomerulus morphology	J:137276
	abnormal spongiotrophoblast layer morphology	J:137276
	albuminuria	J:137276
	hypertension	J:137276
	hypoxia	J:137276
	increased anxiety-related response	J:49475
	increased dopamine level	J:49475
	increased interferon-gamma secretion	J:137276
	increased uterine NK cell number	J:137276
	short gestation period	J:137276
Comt^tm1Mkae/Comt^tm1Mkae involves: C57BL/6J	abnormal xenobiotic pharmacokinetics	J:164057
Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-Comt)1Kndl/0 involves: 129S6/SvEvTac * C57BL/6J	abnormal associative learning	J:225566
	abnormal behavior	J:225566
	abnormal impulsive behavior control	J:225566
	abnormal synaptic dopamine release	J:225566
	abnormal temporal memory	J:225566

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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