Cr2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cr2
complement receptor 2
MGI:88489

37 phenotypes from 7 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cr2^M1Btlr/Cr2^M1Btlr C57BL/6J-Cr2^M1Btlr	decreased IgG level	J:267527
Cr2^M1Btlr/Cr2^M1Btlr C57BL/6J-Cr2^M1Btlr	impaired humoral immune response	J:267527
Cr2^tm1.1Jhws/Cr2^tm1.1Jhws B6.Cg-Cr2^tm1.1Jhws	normal immune system phenotype	J:155241
Cr2^tm1.1Jhws/Cr2^tm1.1Jhws Not Specified	abnormal germinal center B cell physiology	J:205353
	decreased B-1a cell number	J:205353
	decreased IgG2b level	J:205353
	decreased IgG2c level	J:205353
	decreased IgG3 level	J:205353
	decreased IgM level	J:205353
	normal immune system phenotype	J:205353
	increased susceptibility to bacterial infection induced morbidity/mortality	J:205353
Cr2^tm1Crr/Cr2^tm1Crr involves: 129S7/SvEvBrd	decreased follicular B cell number	J:69477
Cr2^tm1Crr/Cr2^tm1Crr involves: 129S7/SvEvBrd	increased marginal zone B cell number	J:69477
Cr2^tm1Crr/Cr2^tm1Crr involves: 129S7/SvEvBrd * C57BL/6	abnormal B-1 B cell morphology	J:31942
	abnormal humoral immune response	J:31942, J:69452
	abnormal immune system morphology	J:69452
	abnormal spleen germinal center morphology	J:31942
	decreased B cell number	J:31942
	decreased B-1a cell number	J:69452
	decreased IgG2a level	J:31942
	decreased IgG2b level	J:31942
	decreased IgG3 level	J:31942
	decreased IgG level	J:31942, J:69452
	decreased IgM level	J:69452
	decreased immunoglobulin level	J:69452
	decreased neutrophil cell number	J:66111
	decreased spleen germinal center number	J:31942, J:69452
	decreased spleen germinal center size	J:31942
	decreased tumor necrosis factor secretion	J:66111
	normal immune system phenotype	J:31942
	increased susceptibility to induced morbidity/mortality	J:66111
	increased susceptibility to injury	J:66111
Cr2^tm1Crr/Cr2^tm1Crr involves: 129S7/SvEvBrd * C57BL/6J	increased anti-double stranded DNA antibody level	J:111811
Cr2^tm1Hmo/Cr2^tm1Hmo B6.129S7-Cr2^tm1Hmo	decreased susceptibility to injury	J:78241
	increased susceptibility to bacterial infection	J:94855
	normal renal/urinary system phenotype	J:103238
Cr2^tm1Hmo/Cr2^tm1Hmo involves: 129S7/SvEvBrd	decreased IgG level	J:35112
Cr2^tm1Hmo/Cr2^tm1Hmo involves: 129S7/SvEvBrd	decreased IgM level	J:35112
Cr2^tm1Hmo/Cr2^tm1Hmo involves: 129S7/SvEvBrd * C57BL/6	abnormal B cell activation	J:151991
	abnormal B cell physiology	J:151991
	abnormal class switch recombination	J:151991
	abnormal memory B cell differentiation	J:151991
Cr2^tm1Tft/Cr2^tm1Tft involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal adaptive immunity	J:95979
	decreased IgG1 level	J:95979
	decreased IgG2b level	J:95979
	decreased IgG3 level	J:95979
	decreased IgG level	J:95979
	decreased IgM level	J:95979
	decreased spleen germinal center number	J:95979
	increased susceptibility to bacterial infection	J:95979
Cr2^{tm2.1(HLA-A)Crr}/Cr2^{tm2.1(HLA-A)Crr} involves: C57BL/6	abnormal B cell physiology	J:151991
	abnormal class switch recombination	J:151991
	abnormal memory B cell differentiation	J:151991
Cr2^tm2.1Jhws/Cr2^tm2.1Jhws B6.129-Cr2^tm2.1Jhws	abnormal germinal center B cell physiology	J:205353
	decreased IgG3 level	J:205353
	decreased IgM level	J:205353
	normal immune system phenotype	J:205353
	increased IgM level	J:205353
	normal mortality/aging	J:205353

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