Creb1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Creb1
cAMP responsive element binding protein 1
MGI:88494

35 phenotypes from 7 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Creb1^tm1.1Berd/Creb1^tm1.1Berd B6NHsd.129S4-Creb1^tm1.1Berd	abnormal myotube morphology	J:177923
	enhanced skeletal muscle regeneration	J:177923
	increased myoblast proliferation	J:177923
	normal muscle phenotype	J:177923
Creb1^tm1.1Khk/Creb1^tm1.1Khk involves: C57BL/6J * FVB/N	normal homeostasis/metabolism phenotype	J:210887
Creb1^tm1Gsc/Creb1^tm1Gsc involves: 129S2/SvPas	abnormal behavioral response to addictive substance	J:34605
	abnormal CNS synaptic transmission	J:20672
	abnormal contextual conditioning behavior	J:20672
	abnormal cued conditioning behavior	J:20672
	abnormal spatial learning	J:20672
	abnormal stellate ganglion morphology	J:121244
	abnormal temporal memory	J:20672
	decreased behavioral withdrawal response	J:34605
	decreased survivor rate	J:18749
	decreased vertical activity	J:34605
	postnatal lethality	J:18749
	reduced long-term potentiation	J:20672
	small superior cervical ganglion	J:121244
Creb1^tm1Nes/Creb1^tm1Nes involves: C57BL/6J	abnormal single cell response	J:164682
Creb1^tm3.1Gsc/Creb1^tm3.1Gsc involves: 129P2/OlaHsd * C57BL/6	abnormal lung development	J:171712
	abnormal lung vasculature morphology	J:171712
	decreased fetal size	J:171712
	impaired lung alveolus development	J:171712
	lethality throughout fetal growth and development, incomplete penetrance	J:171712
	pale lung	J:171712
	small lung	J:171712
Creb1^tm3Gsc/Creb1^tm3Gsc Tg(Cyp17a1-icre)AJako/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	decreased circulating testosterone level	J:170888
	decreased epididymis weight	J:170888
	decreased seminal vesicle weight	J:170888
	decreased testis weight	J:170888
	oligozoospermia	J:170888
	small testis	J:170888
Creb1^tm3Gsc/Creb1^tm3Gsc Tg(Dbh-icre)1Gsc/0 involves: 129P2/OlaHsd * C57BL/6	normal mortality/aging	J:121244
	normal nervous system phenotype	J:121244
Creb1^tm4Gsc/Creb1^tm4Gsc involves: 129P2/OlaHsd * C57BL/6	abnormal circadian behavior phase	J:75993

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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