Creb1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Creb1
cAMP responsive element binding protein 1
MGI:88494

30 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Atf1^tm1Gsc/Atf1⁺ Creb1^tm2Gsc/Creb1⁺ involves: 129/Sv * 129P2/SvPas * C57BL/6	no abnormal phenotype detected	J:74982
Atf1^tm1Gsc/Atf1⁺ Creb1^tm2Gsc/Creb1^tm2Gsc involves: 129/Sv * 129P2/SvPas * C57BL/6	abnormal apoptosis	J:74982
	abnormal blastocyst morphology	J:74982
	abnormal germ layer development	J:74982
	absent allantois	J:74982
	absent amnion	J:74982
	absent blastocoele	J:74982
	absent egg cylinders	J:74982
	absent inner cell mass	J:74982
	delayed blastocyst hatching from the zona pellucida	J:74982
	embryonic lethality, complete penetrance	J:74982
Atf1^tm1Gsc/Atf1^tm1Gsc Creb1^tm2Gsc/Creb1⁺ involves: 129/Sv * 129P2/SvPas * C57BL/6	no abnormal phenotype detected	J:74982
Atf1^tm1Gsc/Atf1^tm1Gsc Creb1^tm2Gsc/Creb1^tm2Gsc involves: 129/Sv * 129P2/SvPas * C57BL/6	abnormal apoptosis	J:74982
	abnormal blastocyst morphology	J:74982
	absent blastocoele	J:74982
	absent inner cell mass	J:74982
	embryonic lethality before implantation, complete penetrance	J:74982
	failure of blastocyst to hatch from the zona pellucida	J:74982
Atf1^tm1Gsc/Atf1^tm1Gsc Creb1^tm3Gsc/Creb1^tm3Gsc Tg(Dbh-icre)1Gsc/0 involves: 129 * 129P2/OlaHsd * C57BL/6	decreased neuron apoptosis	J:121244
Atf4^tm1Kry/Atf4^tm1Kry Creb1^tm3Gsc/Creb1^tm3Gsc Tg(Col1a1-cre)1Kry/0 involves: 129P2/OlaHsd * C57BL/6J * FVB	normal homeostasis/metabolism phenotype	J:152695
Creb1^tm1.1Berd/Creb1^tm1.1Berd Dmd^mdx/Y B.Cg-Creb1^tm1.1Berd Dmd^mdx	enhanced skeletal muscle regeneration	J:177923
	skeletal muscle degeneration	J:177923
Creb1^tm3.1Gsc/Creb1^tm3.1Gsc Crem^tm1Gsc/Crem^tm1Gsc involves: 129P2/OlaHsd * C57BL/6	abnormal lung development	J:171712
Creb1^tm3Gsc/Creb1⁺ Lrp5^tm1Kry/Lrp5⁺ Tg(Col1a1-cre)1Kry/0 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB	decreased bone mass	J:146078
	decreased bone ossification	J:146078
Creb1^tm3Gsc/Creb1⁺ Htr1b^tm1Rhn/Htr1b^tm1Rhn Tg(Col1a1-cre)1Kry/0 involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N	normal skeleton phenotype	J:146078
Creb1^tm3Gsc/Creb1⁺ Gprc6a^tm1.1Kry/Gprc6a⁺ Tg(Cyp17a1-icre)AJako/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	decreased circulating testosterone level	J:170888
	decreased epididymis weight	J:170888
	decreased seminal vesicle weight	J:170888
	decreased testis weight	J:170888
	oligozoospermia	J:170888
	small testis	J:170888
Creb1^tm3Gsc/Creb1^tm3Gsc Crem^tm1Gsc/Crem^tm1Gsc Tg(Camk2a-cre)1Gsc/0 involves: 129P2/OlaHsd * FVB/N	normal behavior/neurological phenotype	J:142518
Creb1^tm3Gsc/Creb1^tm3Gsc Crem^tm1Gsc/Crem^tm1Gsc Tg(Dbh-icre)1Gsc/0 involves: 129P2/OlaHsd * C57BL/6	abnormal superior cervical ganglion morphology	J:121244
	decreased neuron apoptosis	J:121244
	normal mortality/aging	J:121244

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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