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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Crh
corticotropin releasing hormone
MGI:88496
90 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Crhm1H/Crh+
involves: C3H/HeH * C57BL/6J 		abnormal blood homeostasis J:208708
abnormal bone marrow morphology J:208708
abnormal corticosterone level J:208708
abnormal fat cell morphology J:208708
abnormal glucose homeostasis J:208708
abnormal hepatocyte morphology J:208708
abnormal homeostasis J:208708
abnormal urine homeostasis J:208708
decreased body weight J:208708
decreased bone mineral density J:208708
decreased bone mineralization J:208708
decreased bone ossification J:208708
decreased circulating osteocalcin level J:208708
decreased circulating parathyroid hormone level J:208708
decreased lean body mass J:208708
decreased osteoblast cell number J:208708
normal homeostasis/metabolism phenotype J:208708
hyperglycemia J:208708
impaired glucose tolerance J:208708
increased adrenal gland weight J:208708
increased adrenal gland zona fasciculata size J:208708
increased blood uric acid level J:208708
increased body weight J:208708
increased circulating alanine transaminase level J:208708
increased circulating alkaline phosphatase level J:208708
increased circulating aspartate transaminase level J:208708
increased circulating calcium level J:208708
increased circulating cholesterol level J:208708
increased circulating corticosterone level J:208708
increased circulating creatinine level J:208708
increased circulating glucagon level J:208708
increased circulating insulin level J:208708
increased circulating leptin level J:208708
increased circulating total protein level J:208708
increased circulating triglyceride level J:208708
increased total body fat amount J:208708
increased urine calcium level J:208708
increased urine corticosterone level J:208708
increased urine glucose level J:208708
increased urine protein level J:208708
insulin resistance J:208708
obese J:208708
polydipsia J:208708
polyuria J:208708
premature hair loss J:208708
thin skin J:208708
thin tail J:208708
Crhtm1(cre)Zjh/Crhtm1(cre)Zjh
involves: C57BL/6 		no abnormal phenotype detected J:151755
Crhtm1Maj/Crhtm1Maj
involves: 129S2/SvPas * C57BL/6 		abnormal adrenocorticotropin level J:72196, J:102987
abnormal body weight J:105629
abnormal cell-mediated immunity J:98419
abnormal circulating adrenaline level J:105629
abnormal circulating corticosterone level J:54256, J:72196, J:90690, J:102987, J:105629
abnormal circulating glucose level J:102987, J:105629
abnormal circulating hormone level J:90690
abnormal circulating noradrenaline level J:105629
abnormal club cell morphology J:53721
abnormal cytokine secretion J:98419
abnormal epidermis stratum corneum morphology J:49863
abnormal epidermis stratum granulosum morphology J:49863
abnormal food intake J:105629
abnormal inflammatory response J:98419
abnormal lung development J:53721
abnormal professional antigen presenting cell physiology J:98419
abnormal solitary pulmonary neuroendocrine cell morphology J:53721
abnormal surfactant composition J:53721
decreased circulating adrenaline level J:102987
decreased circulating corticosterone level J:105629
decreased circulating leptin level J:105629
decreased inflammatory response J:72196, J:90690
decreased susceptibility to experimental autoimmune encephalomyelitis J:98419
decreased T cell proliferation J:98419
increased circulating interleukin-6 level J:72196
increased mesenchymal cell proliferation involved in lung development J:53721
increased splenocyte number J:98419
Crhtm1Maj/Crhtm1Maj
involves: 129S2/SvPas * C57BL/6J 		abnormal adrenal gland morphology J:23082
abnormal circulating corticosterone level J:23082
abnormal circulating glucose level J:23082
abnormal lung morphology J:23082
abnormal respiratory system physiology J:23082
decreased adrenal gland zona fasciculata size J:23082
maternal effect J:23082
normal nervous system phenotype J:23082
thick pulmonary interalveolar septum J:23082
Crhtm2.1Maj/Crhtm2.1Maj
Tg(Sim1-cre)1Lowl/?
involves: 129S4/SvJae * C57BL/6 * FVB/N 		abnormal adrenal gland secretion J:238330
adrenal gland atrophy J:238330
decreased adrenal gland weight J:238330
decreased anxiety-related response J:238330
decreased circulating adrenocorticotropin level J:238330
decreased circulating corticosterone level J:238330
Crhtm2.2Maj/Crhtm2.2Maj
involves: 129S4/SvJae * C57BL/6 * FVB/N 		abnormal adrenal gland secretion J:238330
adrenal gland atrophy J:238330
decreased circulating corticosterone level J:238330
maternal effect J:238330
Gt(ROSA)26Sortm1(Crh)Jde/Gt(ROSA)26Sortm1(Crh)Jde
Tg(Camk2a-cre/ERT2)2Gsc/0
involves: 129S2/SvPas * C57BL/6J * FVB/N 		increased anxiety-related response J:176339
Gt(ROSA)26Sortm1(Crh)Jde/Gt(ROSA)26Sortm1(Crh)Jde
Tg(Nes-cre)1Kln/0
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal seizure response to pharmacological agent J:140968
decreased susceptibility to neuronal excitotoxicity J:140968
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11/12/2024
MGI 6.24 		The Jackson Laboratory