Crh Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Crh
corticotropin releasing hormone
MGI:88496

43 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Crh^tm1(cre)Zjh/Crh^tm1(cre)Zjh involves: C57BL/6	no abnormal phenotype detected	J:151755
Crh^tm1Maj/Crh^tm1Maj involves: 129S2/SvPas * C57BL/6	abnormal adrenocorticotropin level	J:72196, J:102987
	abnormal body weight	J:105629
	abnormal cell-mediated immunity	J:98419
	abnormal circulating adrenaline level	J:105629
	abnormal circulating corticosterone level	J:54256, J:72196, J:90690, J:102987, J:105629
	abnormal circulating glucose level	J:102987, J:105629
	abnormal circulating hormone level	J:90690
	abnormal circulating noradrenaline level	J:105629
	abnormal club cell morphology	J:53721
	abnormal cytokine secretion	J:98419
	abnormal epidermis stratum corneum morphology	J:49863
	abnormal epidermis stratum granulosum morphology	J:49863
	abnormal food intake	J:105629
	abnormal inflammatory response	J:98419
	abnormal lung development	J:53721
	abnormal professional antigen presenting cell physiology	J:98419
	abnormal solitary pulmonary neuroendocrine cell morphology	J:53721
	abnormal surfactant composition	J:53721
	decreased circulating adrenaline level	J:102987
	decreased circulating corticosterone level	J:105629
	decreased circulating leptin level	J:105629
	decreased inflammatory response	J:72196, J:90690
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:98419
	decreased T cell proliferation	J:98419
	increased circulating interleukin-6 level	J:72196
	increased mesenchymal cell proliferation involved in lung development	J:53721
	increased splenocyte number	J:98419
Crh^tm1Maj/Crh^tm1Maj involves: 129S2/SvPas * C57BL/6J	abnormal adrenal gland morphology	J:23082
	abnormal circulating corticosterone level	J:23082
	abnormal circulating glucose level	J:23082
	abnormal lung morphology	J:23082
	abnormal respiratory system physiology	J:23082
	decreased adrenal gland zona fasciculata size	J:23082
	maternal effect	J:23082
	normal nervous system phenotype	J:23082
	thick pulmonary interalveolar septum	J:23082
Crh^tm2.1Maj/Crh^tm2.1Maj Tg(Sim1-cre)1Lowl/? involves: 129S4/SvJae * C57BL/6 * FVB/N	abnormal adrenal gland secretion	J:238330
	adrenal gland atrophy	J:238330
	decreased adrenal gland weight	J:238330
	decreased anxiety-related response	J:238330
	decreased circulating adrenocorticotropin level	J:238330
	decreased circulating corticosterone level	J:238330
Crh^tm2.2Maj/Crh^tm2.2Maj involves: 129S4/SvJae * C57BL/6 * FVB/N	abnormal adrenal gland secretion	J:238330
	adrenal gland atrophy	J:238330
	decreased circulating corticosterone level	J:238330
	maternal effect	J:238330
Gt(ROSA)26Sor^tm1(Crh)Jde/Gt(ROSA)26Sor^tm1(Crh)Jde Tg(Camk2a-cre/ERT2)2Gsc/0 involves: 129S2/SvPas * C57BL/6J * FVB/N	increased anxiety-related response	J:176339
Gt(ROSA)26Sor^tm1(Crh)Jde/Gt(ROSA)26Sor^tm1(Crh)Jde Tg(Nes-cre)1Kln/0 involves: 129S2/SvPas * C57BL/6 * SJL	abnormal seizure response to pharmacological agent	J:140968
	decreased susceptibility to neuronal excitotoxicity	J:140968

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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