Crhr1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Crhr1
corticotropin releasing hormone receptor 1
MGI:88498

33 phenotypes from 8 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Crhr1^tm1.1Jde/Crhr1^tm1.1Jde involves: 129S2/SvPas * C57BL/6J	normal homeostasis/metabolism phenotype	J:176339
Crhr1^tm1Jde/Crhr1^tm1Jde involves: 129S2/SvPas * C57BL/6J	abnormal corticosterone level	J:176339
Crhr1^tm1Klee/Crhr1^tm1Klee involves: 129S4/SvJae * C57BL/6	abnormal anxiety-related response	J:77641
	abnormal food intake	J:65561
	abnormal hormone level	J:48280
	abnormal learning/memory/conditioning	J:56443
	abnormal lung morphology	J:48280
	adrenal gland atrophy	J:77641
	adrenal gland hypoplasia	J:48280
	decreased adrenal gland zona fasciculata size	J:48280
	decreased anxiety-related response	J:48280, J:56443
	emphysema	J:48280
	normal endocrine/exocrine gland phenotype	J:48280
	normal homeostasis/metabolism phenotype	J:65561
	premature death	J:48280
	pulmonary alveolar hemorrhage	J:48280
	respiratory distress	J:48280
Crhr1^tm1Wrst/Crhr1⁺ either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)	decreased anxiety-related response	J:76022
	decreased behavioral withdrawal response	J:76022
	normal homeostasis/metabolism phenotype	J:76022
Crhr1^tm1Wrst/Crhr1^tm1Wrst either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)	abnormal adrenal medulla morphology	J:76022
	abnormal hormone level	J:76022
	alcohol preference	J:76358
	normal behavior/neurological phenotype	J:76358
	decreased anxiety-related response	J:76022
	decreased behavioral withdrawal response	J:76022
	normal endocrine/exocrine gland phenotype	J:76022
	normal nervous system phenotype	J:76022
	premature death	J:76022
Crhr1^tm1Wrst/Crhr1^tm1Wrst involves: 129P2/OlaHsd	abnormal eye electrophysiology	J:187372
Crhr1^tm1Wrst/Crhr1^tm1Wrst involves: 129P2/OlaHsd	abnormal vision	J:187372
Crhr1^tm2.2Jde/Crhr1^tm2.2Jde involves: 129S2/SvPas * C57BL/6 * SJL	normal homeostasis/metabolism phenotype	J:187372
Crhr1^tm2.3Jde/Crhr1^tm2.3Jde involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac	decreased circulating corticosterone level	J:187372
Crhr1^tm2Jde/Crhr1^tm2Jde involves: 129S2/SvPas * C57BL/6	decreased circulating corticosterone level	J:187372
Crhr1^tm2Wrst/Crhr1^tm2Wrst involves: 129S2/SvPas * C57BL/6	no abnormal phenotype detected	J:85745
Crhr1^tm2Wrst/Crhr1^tm2Wrst Neurod6^tm1(cre)Kan/Neurod6⁺ involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J	abnormal CNS synaptic transmission	J:176339
	normal behavior/neurological phenotype	J:176339
	decreased anxiety-related response	J:176339
	normal homeostasis/metabolism phenotype	J:176339
	hyperactivity	J:176339
Crhr1^tm2Wrst/Crhr1^tm2Wrst Tg(Camk2a-cre)159Kln/0 involves: 129S2/SvPas * C57BL/6	decreased anxiety-related response	J:85745
	increased circulating adrenocorticotropin level	J:85745
	increased circulating corticosterone level	J:85745
	increased locomotor activity	J:85745
Crhr1^tm2Wrst/Crhr1^tm2Wrst Tg(dlx5a-cre)1Mekk/0 involves: 129S2/SvPas * C57BL/6J * CD-1	normal behavior/neurological phenotype	J:176339
	normal homeostasis/metabolism phenotype	J:176339
Crhr1^tm2Wrst/Crhr1^tm2Wrst Tg(Fev-cre)1Esd/0 involves: 129S2/SvPas * C57BL/6 * SJL	abnormal synaptic dopamine release	J:176339
	normal behavior/neurological phenotype	J:176339
	decreased locomotor activity	J:176339
	normal homeostasis/metabolism phenotype	J:176339
	increased anxiety-related response	J:176339
Crhr1^tm2Wrst/Crhr1^tm2Wrst Tg(Nes-cre)1Kln/0 involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL	normal behavior/neurological phenotype	J:176339
Crhr1^tm2Wrst/Crhr1^tm2Wrst Tg(Slc6a3-cre/ERT2)1Span/0 involves: 129S2/SvPas * C57BL/6J	normal behavior/neurological phenotype	J:176339
	normal homeostasis/metabolism phenotype	J:176339
Gt(ROSA)26Sor/Gt(ROSA)26Sor⁺ involves: 129S6/SvEvTac * C57BL/6J	decreased anxiety-related response	J:151155
	decreased circulating corticosterone level	J:151155

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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