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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cryba1
crystallin, beta A1
MGI:88518
24 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cryba1Po1/Cryba1+
C3HeB/FeJ-Cryba1Po1 		total cataract J:58912
Cryba1Po1/Cryba1Po1
C3HeB/FeJ-Cryba1Po1 		microphthalmia J:58912
total cataract J:58912
Cryba1tm1.1Dbsa/Cryba1tm1.1Dbsa
Tg(BEST1-cre)1Jdun/0
involves: 129S6/SvEvTac * C57BL/6 		abnormal lysosome morphology J:215838
abnormal lysosome physiology J:215838
abnormal retina pigment epithelium morphology J:215531, J:215838
abnormal retina pigmentation J:215838
decreased a-wave amplitude J:215838
decreased b-wave amplitude J:215838
gliosis J:215531
impaired autophagy J:215838
increased susceptibility to age-related retinal degeneration J:215531
lysosomal protein accumulation J:215531
Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
involves: C57BL/6J * C57BL/6N 		abnormal autophagy J:235696
abnormal calcium ion homeostasis J:235696
abnormal cell cytoskeleton morphology J:235696
abnormal enzyme/coenzyme activity J:235696
abnormal lens epithelium morphology J:235696
abnormal lens fiber morphology J:235696
abnormal lens morphology J:235696
abnormal lysosome morphology J:235696
abnormal lysosome physiology J:235696
developmental cataract J:235696
increased mitochondrial number J:235696
microphthalmia J:235696
nuclear cataract J:235696
persistent hyaloid artery J:235696
small lens J:235696
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory