Csk Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Csk
c-src tyrosine kinase
MGI:88537

53 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Csk^tm1Sia/Csk⁺ involves: BALB/c * C57BL/6 * CBA	no abnormal phenotype detected	J:12623
Csk^tm1Sia/Csk^tm1Sia involves: BALB/c * C57BL/6 * CBA	abnormal cranial ganglia morphology	J:12623
	abnormal embryonic neuroepithelium morphology	J:12623
	abnormal heart development	J:12623
	abnormal neural tube morphology	J:12623
	abnormal otic vesicle development	J:12623
	absent nasal placodes	J:12623
	absent optic placodes	J:12623
	absent visceral yolk sac blood islands	J:12623
	absent vitelline blood vessels	J:12623
	cellular necrosis	J:12623
	normal cellular phenotype	J:12623
	decreased embryo size	J:12623
	decreased embryonic neuroepithelium thickness	J:12623
	delayed neural tube closure	J:12623
	embryo tissue necrosis	J:12623
	embryonic growth arrest	J:12623
	embryonic growth retardation	J:12623
	embryonic lethality during organogenesis, complete penetrance	J:12623
	incomplete caudal neuropore closure	J:12623
	incomplete embryo turning	J:12623
	incomplete rostral neuropore closure	J:12623
Csk^tm1Sor/Csk⁺ 129P2.129S7-Csk^tm1Sor	abnormal food preference	J:188631
	abnormal object recognition memory	J:188631
	abnormal social investigation	J:188631
	decreased anxiety-related response	J:188631
Csk^tm1Sor/Csk^tm1Sor either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)	abnormal allantois morphology	J:12622
	abnormal cephalic neural fold morphology	J:12622
	absent notochord	J:12622
	caudal body truncation	J:12622
	decreased embryo size	J:12622
	embryonic lethality during organogenesis, complete penetrance	J:12622
	enlarged allantois	J:12622
	incomplete embryo turning	J:12622
	incomplete rostral neuropore closure	J:12622
	megacephaly	J:12622
	open neural tube	J:12622
	poor circulation	J:12622
	wavy neural tube	J:12622
Csk^tm1Tara/Csk^tm1Tara Tg(Mx1-cre)1Cgn/0 involves: 129P2/OlaHsd * C57BL/6 * CB20 * CBA	abnormal CD4-positive T cell differentiation	J:49654
	absent CD8-positive, alpha-beta T cells	J:49654
	enlarged thymus	J:49654
Csk^tm1Tara/Csk^tm2Tara Elane^tm1(cre)Roes/Elane⁺ involves: 129P2/OlaHsd * CB20 * C57BL/6	abnormal granulocyte physiology	J:89716
	abnormal myelopoiesis	J:89716
	increased acute inflammation	J:89716
	increased susceptibility to bacterial infection	J:89716
Csk^{tm2b(EUCOMM)Hmgu}/Csk⁺ C57BL/6N-Csk^{tm2b(EUCOMM)Hmgu}/Bay	abnormal retina inner nuclear layer morphology	J:211773
	abnormal retina vasculature morphology	J:211773
	decreased total retina thickness	J:211773
Csk^{tm2b(EUCOMM)Hmgu}/Csk^{tm2b(EUCOMM)Hmgu} C57BL/6N-Csk^{tm2b(EUCOMM)Hmgu}/Bay	abnormal embryo development	J:211773
	abnormal embryo size	J:211773
	abnormal embryo turning	J:211773
	abnormal neural tube closure	J:211773
	embryonic growth retardation	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Csk^tm2Sia/Csk^tm2Sia involves: BALB/c * C57BL/6 * CBA	abnormal cranial ganglia morphology	J:12623
	abnormal lens induction	J:12623
	abnormal neural tube morphology	J:12623
	abnormal otic vesicle development	J:12623
	absent olfactory bulb	J:12623
	absent visceral yolk sac blood islands	J:12623
	absent vitelline blood vessels	J:12623
	cellular necrosis	J:12623
	normal cellular phenotype	J:12623
	decreased embryo size	J:12623
	embryo tissue necrosis	J:12623
	embryonic growth arrest	J:12623
	embryonic growth retardation	J:12623
	embryonic lethality during organogenesis, complete penetrance	J:12623
	incomplete embryo turning	J:12623
	incomplete rostral neuropore closure	J:12623
	open neural tube	J:12623

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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