Ctla4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ctla4
cytotoxic T-lymphocyte-associated protein 4
MGI:88556

45 phenotypes from 6 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ctla4^m1Btlr/Ctla4^m1Btlr C57BL/6J-Ctla4^m1Btlr	decreased CD8-positive, naive alpha-beta T cell number	J:265263
	increased effector memory CD4-positive, alpha-beta T cell number	J:265263
	increased effector memory CD8-positive, alpha-beta T cell number	J:265263
Ctla4^tm1All/Ctla4^tm1All involves: 129S1/Sv * 129X1/SvJ	abnormal thymus morphology	J:42481
	decreased double-positive T cell number	J:42481
	decreased T cell number	J:42481
	increased double-negative T cell number	J:42481
	lymph node hypoplasia	J:42481
	premature death	J:42481
Ctla4^tm1All/Ctla4^tm1All involves: 129S1/Sv * 129X1/SvJ * C57BL/6	variable depigmentation	J:140448
Ctla4^tm1All/Ctla4^tm1All involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD	increased acute inflammation	J:109887
	premature death	J:109887
Ctla4^tm1Mak/Ctla4^tm1Mak involves: 129P2/OlaHsd * BALB/c	increased interferon-gamma secretion	J:140085
	increased interleukin-2 secretion	J:140085
	increased interleukin-4 secretion	J:140085
	increased interleukin-17 secretion	J:140085
	premature death	J:140085
Ctla4^tm1Saka/Ctla4^tm1Saka Foxp3^tm1(cre)Saka/Y involves: BALB/c	abnormal immunoglobulin level	J:140085
	abnormal liver morphology	J:140085
	abnormal regulatory T cell physiology	J:140085
	abnormal splenic cell ratio	J:140085
	enlarged heart	J:140085
	increased autoantibody level	J:140085
	increased IgE level	J:140085
	increased IgG level	J:140085
	increased inflammatory response	J:140085
	increased interferon-gamma secretion	J:140085
	increased interleukin-2 secretion	J:140085
	increased interleukin-4 secretion	J:140085
	increased regulatory T cell number	J:140085
	lung inflammation	J:140085
	lymph node hyperplasia	J:140085
	myocarditis	J:140085
	premature death	J:140085
	salivary gland inflammation	J:140085
	spleen hyperplasia	J:140085
	stomach inflammation	J:140085
Ctla4^tm1Shr/Ctla4^tm1Shr B6.129S4-Ctla4^tm1Shr	abnormal regulatory T cell physiology	J:146644
	abnormal T cell physiology	J:146644
	autoimmune response	J:146644
Ctla4^tm1Shr/Ctla4^tm1Shr C.129S4-Ctla4^tm1Shr	premature death	J:57090
Ctla4^tm1Shr/Ctla4^tm1Shr either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)	abnormal cytokine secretion	J:30393
	abnormal lymph node cell ratio	J:30393
	abnormal splenic cell ratio	J:30393
	abnormal T cell differentiation	J:30393
	abnormal T cell morphology	J:30393
	decreased double-positive T cell number	J:30393
	enlarged lymph nodes	J:30393
	enlarged spleen	J:30393
	increased double-negative T cell number	J:30393
	increased T cell number	J:30393
	increased T cell proliferation	J:30393
	joint inflammation	J:30393
	lung inflammation	J:30393
	myocarditis	J:30393
	pancreas inflammation	J:30393
	premature death	J:30393
	salivary gland inflammation	J:30393
	vascular inflammation	J:30393
Ctla4^tm1Yliu/Ctla4^tm1Yliu B6.129-Ctla4^tm1Yliu	no abnormal phenotype detected	J:123940

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24