Ctla4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ctla4
cytotoxic T-lymphocyte-associated protein 4
MGI:88556

45 phenotypes from 6 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ctla4^m1Btlr/Ctla4^m1Btlr C57BL/6J-Ctla4^m1Btlr	decreased CD8-positive, naive alpha-beta T cell number	J:265263
	increased effector memory CD4-positive, alpha-beta T cell number	J:265263
	increased effector memory CD8-positive, alpha-beta T cell number	J:265263
Ctla4^tm1All/Ctla4^tm1All involves: 129S1/Sv * 129X1/SvJ	abnormal thymus morphology	J:42481
	decreased double-positive T cell number	J:42481
	decreased T cell number	J:42481
	increased double-negative T cell number	J:42481
	lymph node hypoplasia	J:42481
	premature death	J:42481
Ctla4^tm1All/Ctla4^tm1All involves: 129S1/Sv * 129X1/SvJ * C57BL/6	variable depigmentation	J:140448
Ctla4^tm1All/Ctla4^tm1All involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD	increased acute inflammation	J:109887
	premature death	J:109887
Ctla4^tm1Mak/Ctla4^tm1Mak involves: 129P2/OlaHsd * BALB/c	increased interferon-gamma secretion	J:140085
	increased interleukin-2 secretion	J:140085
	increased interleukin-4 secretion	J:140085
	increased interleukin-17 secretion	J:140085
	premature death	J:140085
Ctla4^tm1Saka/Ctla4^tm1Saka Foxp3^tm1(cre)Saka/Y involves: BALB/c	abnormal immunoglobulin level	J:140085
	abnormal liver morphology	J:140085
	abnormal regulatory T cell physiology	J:140085
	abnormal splenic cell ratio	J:140085
	enlarged heart	J:140085
	increased autoantibody level	J:140085
	increased IgE level	J:140085
	increased IgG level	J:140085
	increased inflammatory response	J:140085
	increased interferon-gamma secretion	J:140085
	increased interleukin-2 secretion	J:140085
	increased interleukin-4 secretion	J:140085
	increased regulatory T cell number	J:140085
	lung inflammation	J:140085
	lymph node hyperplasia	J:140085
	myocarditis	J:140085
	premature death	J:140085
	salivary gland inflammation	J:140085
	spleen hyperplasia	J:140085
	stomach inflammation	J:140085
Ctla4^tm1Shr/Ctla4^tm1Shr B6.129S4-Ctla4^tm1Shr	abnormal regulatory T cell physiology	J:146644
	abnormal T cell physiology	J:146644
	autoimmune response	J:146644
Ctla4^tm1Shr/Ctla4^tm1Shr C.129S4-Ctla4^tm1Shr	premature death	J:57090
Ctla4^tm1Shr/Ctla4^tm1Shr either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)	abnormal cytokine secretion	J:30393
	abnormal lymph node cell ratio	J:30393
	abnormal splenic cell ratio	J:30393
	abnormal T cell differentiation	J:30393
	abnormal T cell morphology	J:30393
	decreased double-positive T cell number	J:30393
	enlarged lymph nodes	J:30393
	enlarged spleen	J:30393
	increased double-negative T cell number	J:30393
	increased T cell number	J:30393
	increased T cell proliferation	J:30393
	joint inflammation	J:30393
	lung inflammation	J:30393
	myocarditis	J:30393
	pancreas inflammation	J:30393
	premature death	J:30393
	salivary gland inflammation	J:30393
	vascular inflammation	J:30393
Ctla4^tm1Yliu/Ctla4^tm1Yliu B6.129-Ctla4^tm1Yliu	no abnormal phenotype detected	J:123940

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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