Ctsb Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ctsb
cathepsin B
MGI:88561

24 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cacna1a^tm2.1Kewa/Cacna1a^tm2.1Kewa Ctsb^tm1Jde/Ctsb⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal motor coordination/balance	J:190729
Cacna1a^tm2.1Kewa/Cacna1a^tm2.1Kewa Ctsb^tm1Jde/Ctsb^tm1Jde involves: 129P2/OlaHsd * C57BL/6	abnormal motor coordination/balance	J:190729
	abnormal Purkinje cell morphology	J:190729
	Purkinje cell degeneration	J:190729
Cacna1a^tm3Hzo/Cacna1a^tm3Hzo Ctsb^tm1Jde/Ctsb^tm1Jde involves: 129P2/OlaHsd * 129S/SvEv	Purkinje cell degeneration	J:190729
Ctsb^tm1Jde/Ctsb^tm1Jde Ctsk^tm1Psa/Ctsk^tm1Psa involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J	abnormal thyroid follicle morphology	J:83877
	abnormal thyroid follicular cell morphology	J:83877
	abnormal thyroid hormone level	J:83877
Ctsb^tm1Jde/Ctsb^tm1Jde Ctsl^tm1Cptr/Ctsl^tm1Cptr involves: 129P2/OlaHsd * C57BL/6J	abnormal hippocampus pyramidal cell layer	J:77103
	abnormal motor coordination/balance	J:77103
	abnormal neuron apoptosis	J:77103
	decreased vertical activity	J:77103
	delayed hair appearance	J:77103
	gliosis	J:77103
	neuron degeneration	J:77103
	postnatal growth retardation	J:77103
	postnatal lethality, incomplete penetrance	J:77103
	Purkinje cell degeneration	J:77103
	thick epidermis	J:77103
	tremors	J:77103
Ctsb^tm1Jde/Ctsb^tm1Jde Ctsz^tm1Thre/Ctsz^tm1Thre FVB.129P2-Ctsz^tm1Thre Ctsb^tm1Jde	no abnormal phenotype detected	J:157541
Ctsb^tm1Jde/Ctsb^tm1Jde Ctsz^tm1Thre/Ctsz^tm1Thre Tg(MMTV-PyVT)634Mul/0 FVB.129P2-Ctsz^tm1Thre Ctsb^tm1Jde Tg(MMTV-PyVT)634Mul	abnormal tumor morphology	J:157541
	decreased apoptosis	J:157541
	decreased metastatic potential	J:157541
	decreased tumor growth/size	J:157541
	increased mammary gland tumor incidence	J:157541
	increased tumor latency	J:157541
Ctsb^tm1Jde/Ctsb^tm1Jde Serpina3g^tm1.1Arp/Serpina3g^tm1.1Arp involves: 129P2/OlaHsd * C57BL/6	normal immune system phenotype	J:189782
Ctsb^tm1Jde/Ctsb^tm1Jde Tg(MMTV-PyVT)634Mul/0 FVB.129P2-Ctsb^tm1Jde Tg(MMTV-PyVT)634Mul	abnormal tumor morphology	J:157541
	decreased metastatic potential	J:157541
	decreased tumor growth/size	J:157541
	increased mammary gland tumor incidence	J:157541
	increased tumor latency	J:157541

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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