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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ctsd
cathepsin D
MGI:88562
48 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ctsdm1J/Ctsdm1J
C3HeB/FeJ-Ctsdm1J/GrsrJ 		abnormal cochlear ganglion morphology J:229377
abnormal hair cycle J:229377
abnormal intestinal mucosa morphology J:229377
abnormal stomach wall morphology J:229377
axonal dystrophy J:229377
cachexia J:229377
deafness J:229377
decreased body weight J:229377
hippocampal neuron degeneration J:229377
increased or absent threshold for auditory brainstem response J:229377
lethality at weaning, complete penetrance J:229377
neuron degeneration J:229377
prenatal lethality, incomplete penetrance J:229377
preweaning lethality, incomplete penetrance J:229377
thymus atrophy J:229377
weakness J:229377
Ctsdtm1.1Thre/Ctsdtm1.1Thre
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * C57BL/6N * CBA * SJL 		astrocytosis J:227618
decreased body weight J:227618
decreased double-positive T cell number J:227618
decreased small intestinal villus height J:227618
gliosis J:227618
microgliosis J:227618
neuron degeneration J:227618
premature death J:227618
small intestinal villus atrophy J:227618
thymus atrophy J:227618
weight loss J:227618
Ctsdtm1.1Thre/Ctsdtm1.1Thre
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * C57BL/6N * SJL 		abnormal thymus morphology J:227618
astrocytosis J:227618
decreased body weight J:227618
decreased double-positive T cell number J:227618
decreased small intestinal villus height J:227618
gliosis J:227618
microgliosis J:227618
neuron degeneration J:227618
premature death J:227618
small intestinal villus atrophy J:227618
Ctsdtm1b(EUCOMM)Wtsi/Ctsd+
C57BL/6N-Ctsdtm1b(EUCOMM)Wtsi/Ics 		cornea opacity J:211773
decreased hematocrit J:211773
increased circulating aspartate transaminase level J:211773
Ctsdtm1b(EUCOMM)Wtsi/Ctsdtm1b(EUCOMM)Wtsi
C57BL/6N-Ctsdtm1b(EUCOMM)Wtsi/Ics 		preweaning lethality, incomplete penetrance J:211773
Ctsdtm1Cptr/Ctsdtm1Cptr
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd) 		abnormal antigen presentation J:47432
abnormal crypts of Lieberkuhn morphology J:28201
abnormal ileum morphology J:28201
abnormal intestinal mucosa morphology J:28201, J:71688
abnormal microglial cell morphology J:71688
abnormal retina morphology J:82765
abnormal spleen B cell follicle morphology J:28201
abnormal spleen white pulp morphology J:28201
abnormal thrombosis J:28201
ataxia J:28201
blindness J:82765
bradykinesia J:28201
normal cellular phenotype J:28201
decreased body weight J:28201, J:71688
decreased double-positive T cell number J:28201
decreased food intake J:28201
decreased lymphocyte cell number J:28201
increased forebrain apoptosis J:71688
lysosomal protein accumulation J:64892
premature death J:28201, J:71688
retina photoreceptor degeneration J:82765
seizures J:64892, J:71688
thymus hypoplasia J:28201
tonic seizures J:64892
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory