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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ctsl
cathepsin L
MGI:88564
117 phenotypes from 7 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ctslfs/Ctslfs
involves: C57BL/6 * FSB/GnEi 		abnormal seminiferous tubule morphology J:81950
abnormal spermatogenesis J:81950
decreased testis weight J:81950
Ctslfs/Ctslfs
involves: C57BL/6 * unpedigreed stock 		absent vibrissae J:15332
alopecia J:15332
postnatal lethality, incomplete penetrance J:5217
Ctslm1Btlr/Ctslm1Btlr
C57BL/6J-Ctslm1Btlr 		abnormal CD4-positive T cell differentiation J:272869
abnormal CD8-positive, alpha beta T cell morphology J:272869
abnormal CD8-positive, alpha-beta T cell differentiation J:272869
abnormal T cell differentiation J:272869
alopecia J:272869
decreased alpha-beta T cell number J:272869
decreased CD4-positive, alpha-beta T cell number J:272869
increased alpha-beta T cell number J:272869
increased CD8-positive, alpha-beta T cell number J:272869
increased central memory CD4-positive, alpha-beta T cell number J:272869
increased central memory CD8 positive, alpha-beta T cell number J:272869
increased effector memory CD4-positive, alpha-beta T cell number J:272869
Ctslnkt/Ctslnkt
B6.Cg-Ctslnkt 		abnormal coat/ hair morphology J:78460
abnormal external auditory canal morphology J:78460
abnormal hair cycle catagen phase J:78460
abnormal hair follicle development J:78460
abnormal hair growth J:78460
abnormal hair shaft morphology J:78460
acanthosis J:78460
alopecia J:78460
cornea opacity J:78460
decreased body size J:78460
delayed hair appearance J:78460
dental pulp necrosis J:78460
dermatitis J:78460
dilated piliary canal J:78460
enlarged lymph nodes J:78460
enlarged sebaceous gland J:78460
epidermal hyperplasia J:78460
excessive scratching J:78460
normal integument phenotype J:78460
orthokeratosis J:78460
periodontal ligament necrosis J:78460
skin lesions J:78460
sparse hair J:78460
thick dermal layer J:78460
Ctslnkt/Ctslnkt
C.Cg-Ctslnkt 		abnormal coat/ hair morphology J:78460
abnormal external auditory canal morphology J:78460
abnormal hair cycle catagen phase J:78460
abnormal hair follicle development J:78460
abnormal hair growth J:78460
abnormal hair shaft morphology J:78460
abnormal immune system organ morphology J:78460
abnormal leukocyte cell number J:99009
abnormal lymph node cortex morphology J:99009
abnormal lymph node morphology J:99009
abnormal thymus corticomedullary boundary morphology J:99009
abnormal thymus lobule morphology J:99009
abnormal thymus morphology J:99009
acanthosis J:78460
alopecia J:78460
cornea opacity J:78460
decreased body size J:78460
decreased CD4-positive, alpha-beta T cell number J:99009
delayed hair appearance J:78460
dental pulp necrosis J:78460
dermatitis J:78460
dilated lymph node medullary sinus J:99009
dilated piliary canal J:78460
enlarged lymph nodes J:78460, J:99009
enlarged sebaceous gland J:78460
enlarged thymus cortex J:99009
excessive scratching J:78460
increased CD8-positive, alpha-beta T cell number J:99009
normal integument phenotype J:78460
orthokeratosis J:78460
periodontal ligament necrosis J:78460
skin lesions J:78460
sparse hair J:78460
thick dermal layer J:78460
thick epidermis J:78460
Ctslnkt/Ctslnkt
either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2) 		abnormal coat/ hair morphology J:54856
abnormal hair follicle morphology J:54856
abnormal hair growth J:54856
abnormal immune system organ morphology J:54856
acanthosis J:54856
alopecia J:54856
cachexia J:54856
decreased CD4-positive, alpha-beta T cell number J:54856
dermatitis J:54856
enlarged sebaceous gland J:54856
epidermal hyperplasia J:54856
excessive scratching J:54856
hypergranulosis J:54856
increased inflammatory response J:54856
liver inflammation J:54856
lymph node hyperplasia J:54856
lymph node inflammation J:54856
orthokeratosis J:54856
postnatal growth retardation J:54856
postnatal lethality, incomplete penetrance J:54856
rough coat J:54856
skin lesions J:54856
sparse hair J:54856
thymus atrophy J:54856
Ctsltm1.1Thre/Ctsltm1.1Thre
involves: C57BL/6 * C57BL/6N 		alopecia J:216506
Ctsltm1.2Thre/Ctsl+
involves: C57BL/6 * C57BL/6N 		normal integument phenotype J:216506
Ctsltm1.2Thre/Ctsltm1.2Thre
involves: C57BL/6 * C57BL/6N 		alopecia J:216506
decreased CD4-positive, alpha-beta T cell number J:216506
epidermal hyperplasia J:216506
increased keratinocyte proliferation J:216506
thick epidermis J:216506
Ctsltm1Alpk/Ctsl+
involves: 129P2/OlaHsd * C57BL/6 		abnormal cartilage morphology J:99755
abnormal trabecular bone morphology J:99755
focal dorsal hair loss J:99755
Ctsltm1Alpk/Ctsltm1Alpk
B6.129P2-Ctsltm1Alpk 		abnormal hair follicle orientation J:99755
abnormal keratinocyte physiology J:99755
alopecia J:99755
granulomatous inflammation J:99755
thick epidermis J:99755
Ctsltm1Alpk/Ctsltm1Alpk
involves: 129P2/OlaHsd * C57BL/6 		abnormal cartilage morphology J:99755
abnormal coat appearance J:99755
abnormal coat/ hair morphology J:99755
abnormal hair cycle J:99755
abnormal hair follicle morphology J:99755
abnormal hair follicle orientation J:99755
abnormal hair growth J:99755
abnormal hair shaft morphology J:99755
abnormal osteoclast physiology J:99755
abnormal trabecular bone morphology J:99755
alopecia J:99755
decreased long bone epiphyseal plate size J:99755
decreased osteoclast cell number J:99755
dermatitis J:99755
epidermal hyperplasia J:99755
folliculitis J:99755
granulomatous inflammation J:99755
greasy coat J:99755
short hair J:99755
short vibrissae J:99755
sparse vibrissae J:99755
Ctsltm1Cptr/Ctsl+
NOD.129P2-Ctsltm1Cptr 		decreased susceptibility to autoimmune diabetes J:153355
hyperglycemia J:153355
insulitis J:153355
Ctsltm1Cptr/Ctsltm1Cptr
involves: 129P2/OlaHsd 		abnormal cardiovascular system physiology J:76333
abnormal heart echocardiography feature J:76333
abnormal heart electrocardiography waveform feature J:76333
abnormal heartbeat J:76333
abnormal lysosome morphology J:216506
abnormal myocardial fiber morphology J:76333
abnormal myocardium layer morphology J:76333
abnormal R wave J:76333
abnormal T wave J:76333
abnormal visceral endoderm morphology J:216506
abnormal visceral yolk sac morphology J:216506
alopecia J:216506
aortic valve regurgitation J:76333
atrioventricular block J:76333
cardiac interstitial fibrosis J:76333
decreased cardiac muscle contractility J:76333
decreased CD4-positive, alpha-beta T cell number J:216506
decreased heart left ventricle muscle contractility J:76333
dilated cardiomyopathy J:76333
enlarged heart J:76333
epidermal hyperplasia J:216506
heart left ventricle hypertrophy J:76333
increased heart left atrium size J:76333
increased heart rate J:76333
increased heart weight J:76333
increased keratinocyte proliferation J:216506
mitral valve regurgitation J:76333
postnatal lethality, incomplete penetrance J:76333
thick epidermis J:216506
Ctsltm1Cptr/Ctsltm1Cptr
involves: 129P2/OlaHsd * C57BL/6J 		abnormal epidermis stratum basale morphology J:70118
abnormal hair cycle J:70118
abnormal hair follicle development J:70118
abnormal hair shaft morphology J:70118
abnormal thyroid gland morphology J:83877
abnormal thyroid hormone level J:83877
absent vibrissae J:70118
acanthosis J:70118
alopecia J:70118
amyloidosis J:116135
decreased thyroxine level J:83877
delayed hair appearance J:70118
dilated piliary canal J:70118
epidermal hyperplasia J:70118
hair follicle outer root sheath hyperplasia J:70118
hyperkeratosis J:70118
increased keratinocyte proliferation J:70118
increased regulatory T cell number J:153355
postnatal lethality, incomplete penetrance J:70118
normal renal/urinary system phenotype J:172774
scaly skin J:70118
shiny skin J:70118
thick dermal layer J:70118
thick epidermis J:70118
thick skin J:70118
underdeveloped hair follicles J:70118
Ctsltm1Cptr/Ctsltm1Cptr
NOD.129P2-Ctsltm1Cptr 		decreased CD4-positive, alpha-beta T cell number J:153355
decreased susceptibility to autoimmune diabetes J:153355
increased regulatory T cell number J:153355
salivary gland inflammation J:153355
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory