About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ctsl
cathepsin L
MGI:88564
117 phenotypes from 7 alleles in 12 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Ctslfs/Ctslfs
involves: C57BL/6 * FSB/GnEi 		abnormal seminiferous tubule morphology J:81950
abnormal spermatogenesis J:81950
decreased testis weight J:81950
Ctslfs/Ctslfs
involves: C57BL/6 * unpedigreed stock 		absent vibrissae J:15332
alopecia J:15332
postnatal lethality, incomplete penetrance J:5217
Ctslm1Btlr/Ctslm1Btlr
C57BL/6J-Ctslm1Btlr 		abnormal CD4-positive T cell differentiation J:272869
abnormal CD8-positive, alpha beta T cell morphology J:272869
abnormal CD8-positive, alpha-beta T cell differentiation J:272869
abnormal T cell differentiation J:272869
alopecia J:272869
decreased alpha-beta T cell number J:272869
decreased CD4-positive, alpha-beta T cell number J:272869
increased alpha-beta T cell number J:272869
increased CD8-positive, alpha-beta T cell number J:272869
increased central memory CD4-positive, alpha-beta T cell number J:272869
increased central memory CD8 positive, alpha-beta T cell number J:272869
increased effector memory CD4-positive, alpha-beta T cell number J:272869
Ctslnkt/Ctslnkt
B6.Cg-Ctslnkt 		abnormal coat/ hair morphology J:78460
abnormal external auditory canal morphology J:78460
abnormal hair cycle catagen phase J:78460
abnormal hair follicle development J:78460
abnormal hair growth J:78460
abnormal hair shaft morphology J:78460
acanthosis J:78460
alopecia J:78460
cornea opacity J:78460
decreased body size J:78460
delayed hair appearance J:78460
dental pulp necrosis J:78460
dermatitis J:78460
dilated piliary canal J:78460
enlarged lymph nodes J:78460
enlarged sebaceous gland J:78460
epidermal hyperplasia J:78460
excessive scratching J:78460
normal integument phenotype J:78460
orthokeratosis J:78460
periodontal ligament necrosis J:78460
skin lesions J:78460
sparse hair J:78460
thick dermal layer J:78460
Ctslnkt/Ctslnkt
C.Cg-Ctslnkt 		abnormal coat/ hair morphology J:78460
abnormal external auditory canal morphology J:78460
abnormal hair cycle catagen phase J:78460
abnormal hair follicle development J:78460
abnormal hair growth J:78460
abnormal hair shaft morphology J:78460
abnormal immune system organ morphology J:78460
abnormal leukocyte cell number J:99009
abnormal lymph node cortex morphology J:99009
abnormal lymph node morphology J:99009
abnormal thymus corticomedullary boundary morphology J:99009
abnormal thymus lobule morphology J:99009
abnormal thymus morphology J:99009
acanthosis J:78460
alopecia J:78460
cornea opacity J:78460
decreased body size J:78460
decreased CD4-positive, alpha-beta T cell number J:99009
delayed hair appearance J:78460
dental pulp necrosis J:78460
dermatitis J:78460
dilated lymph node medullary sinus J:99009
dilated piliary canal J:78460
enlarged lymph nodes J:78460, J:99009
enlarged sebaceous gland J:78460
enlarged thymus cortex J:99009
excessive scratching J:78460
increased CD8-positive, alpha-beta T cell number J:99009
normal integument phenotype J:78460
orthokeratosis J:78460
periodontal ligament necrosis J:78460
skin lesions J:78460
sparse hair J:78460
thick dermal layer J:78460
thick epidermis J:78460
Ctslnkt/Ctslnkt
either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2) 		abnormal coat/ hair morphology J:54856
abnormal hair follicle morphology J:54856
abnormal hair growth J:54856
abnormal immune system organ morphology J:54856
acanthosis J:54856
alopecia J:54856
cachexia J:54856
decreased CD4-positive, alpha-beta T cell number J:54856
dermatitis J:54856
enlarged sebaceous gland J:54856
epidermal hyperplasia J:54856
excessive scratching J:54856
hypergranulosis J:54856
increased inflammatory response J:54856
liver inflammation J:54856
lymph node hyperplasia J:54856
lymph node inflammation J:54856
orthokeratosis J:54856
postnatal growth retardation J:54856
postnatal lethality, incomplete penetrance J:54856
rough coat J:54856
skin lesions J:54856
sparse hair J:54856
thymus atrophy J:54856
Ctsltm1.1Thre/Ctsltm1.1Thre
involves: C57BL/6 * C57BL/6N 		alopecia J:216506
Ctsltm1.2Thre/Ctsl+
involves: C57BL/6 * C57BL/6N 		normal integument phenotype J:216506
Ctsltm1.2Thre/Ctsltm1.2Thre
involves: C57BL/6 * C57BL/6N 		alopecia J:216506
decreased CD4-positive, alpha-beta T cell number J:216506
epidermal hyperplasia J:216506
increased keratinocyte proliferation J:216506
thick epidermis J:216506
Ctsltm1Alpk/Ctsl+
involves: 129P2/OlaHsd * C57BL/6 		abnormal cartilage morphology J:99755
abnormal trabecular bone morphology J:99755
focal dorsal hair loss J:99755
Ctsltm1Alpk/Ctsltm1Alpk
B6.129P2-Ctsltm1Alpk 		abnormal hair follicle orientation J:99755
abnormal keratinocyte physiology J:99755
alopecia J:99755
granulomatous inflammation J:99755
thick epidermis J:99755
Ctsltm1Alpk/Ctsltm1Alpk
involves: 129P2/OlaHsd * C57BL/6 		abnormal cartilage morphology J:99755
abnormal coat appearance J:99755
abnormal coat/ hair morphology J:99755
abnormal hair cycle J:99755
abnormal hair follicle morphology J:99755
abnormal hair follicle orientation J:99755
abnormal hair growth J:99755
abnormal hair shaft morphology J:99755
abnormal osteoclast physiology J:99755
abnormal trabecular bone morphology J:99755
alopecia J:99755
decreased long bone epiphyseal plate size J:99755
decreased osteoclast cell number J:99755
dermatitis J:99755
epidermal hyperplasia J:99755
folliculitis J:99755
granulomatous inflammation J:99755
greasy coat J:99755
short hair J:99755
short vibrissae J:99755
sparse vibrissae J:99755
Ctsltm1Cptr/Ctsl+
NOD.129P2-Ctsltm1Cptr 		decreased susceptibility to autoimmune diabetes J:153355
hyperglycemia J:153355
insulitis J:153355
Ctsltm1Cptr/Ctsltm1Cptr
involves: 129P2/OlaHsd 		abnormal cardiovascular system physiology J:76333
abnormal heart echocardiography feature J:76333
abnormal heart electrocardiography waveform feature J:76333
abnormal heartbeat J:76333
abnormal lysosome morphology J:216506
abnormal myocardial fiber morphology J:76333
abnormal myocardium layer morphology J:76333
abnormal R wave J:76333
abnormal T wave J:76333
abnormal visceral endoderm morphology J:216506
abnormal visceral yolk sac morphology J:216506
alopecia J:216506
aortic valve regurgitation J:76333
atrioventricular block J:76333
cardiac interstitial fibrosis J:76333
decreased cardiac muscle contractility J:76333
decreased CD4-positive, alpha-beta T cell number J:216506
decreased heart left ventricle muscle contractility J:76333
dilated cardiomyopathy J:76333
enlarged heart J:76333
epidermal hyperplasia J:216506
heart left ventricle hypertrophy J:76333
increased heart left atrium size J:76333
increased heart rate J:76333
increased heart weight J:76333
increased keratinocyte proliferation J:216506
mitral valve regurgitation J:76333
postnatal lethality, incomplete penetrance J:76333
thick epidermis J:216506
Ctsltm1Cptr/Ctsltm1Cptr
involves: 129P2/OlaHsd * C57BL/6J 		abnormal epidermis stratum basale morphology J:70118
abnormal hair cycle J:70118
abnormal hair follicle development J:70118
abnormal hair shaft morphology J:70118
abnormal thyroid gland morphology J:83877
abnormal thyroid hormone level J:83877
absent vibrissae J:70118
acanthosis J:70118
alopecia J:70118
amyloidosis J:116135
decreased thyroxine level J:83877
delayed hair appearance J:70118
dilated piliary canal J:70118
epidermal hyperplasia J:70118
hair follicle outer root sheath hyperplasia J:70118
hyperkeratosis J:70118
increased keratinocyte proliferation J:70118
increased regulatory T cell number J:153355
postnatal lethality, incomplete penetrance J:70118
normal renal/urinary system phenotype J:172774
scaly skin J:70118
shiny skin J:70118
thick dermal layer J:70118
thick epidermis J:70118
thick skin J:70118
underdeveloped hair follicles J:70118
Ctsltm1Cptr/Ctsltm1Cptr
NOD.129P2-Ctsltm1Cptr 		decreased CD4-positive, alpha-beta T cell number J:153355
decreased susceptibility to autoimmune diabetes J:153355
increased regulatory T cell number J:153355
salivary gland inflammation J:153355
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory