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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
MGI:88582
51 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cyp11a1tm1(GFP/cre)Pzg/Cyp11a1+
involves: 129P2/OlaHsd * C57BL/6J 		no abnormal phenotype detected J:159099
Cyp11a1tm1.1Bcc/Cyp11a1tm1.1Bcc
B6.129(FVB)-Cyp11a1tm1.1Bcc 		abnormal adrenal gland morphology J:191801
abnormal adrenocortical cell morphology J:191801
abnormal corticosterone level J:191801
abnormal mitochondrial morphology J:191801
absent adrenal chromaffin cells J:191801
decreased adrenaline level J:191801
decreased noradrenaline level J:191801
increased circulating adrenocorticotropin level J:191801
neonatal lethality, complete penetrance J:191801
Cyp11a1tm1b(EUCOMM)Hmgu/Cyp11a1tm1b(EUCOMM)Hmgu
C57BL/6N-Cyp11a1tm1b(EUCOMM)Hmgu/Wtsi 		abnormal optic cup morphology J:239583
absent segment of posterior cerebral artery J:239583
dilated bile duct J:239583
dilated liver sinusoidal space J:239583
hemopericardium J:239583
preweaning lethality, complete penetrance J:211773
retrolental blood J:239583
thin hypoglossal nerve J:239583
Cyp11a1tm1Bcc/Cyp11a1tm1Bcc
involves: 129 * C57BL/6 		abnormal adrenal cortex morphology J:78062
abnormal circulating potassium level J:78062
abnormal circulating sodium level J:78062
abnormal epididymis epithelium morphology J:78062
abnormal epididymis morphology J:78062
abnormal lipid level J:78062
abnormal seminiferous tubule morphology J:78062
abnormal spermatogenesis J:78062
abnormal testis morphology J:78062
abnormal vas deferens morphology J:78062
absent bulbourethral gland J:78062
absent prostate gland J:78062
absent prostate gland anterior lobe J:78062
absent scrotum J:78062
decreased circulating aldosterone level J:78062
decreased circulating corticosterone level J:78062
decreased food intake J:78062
decreased locomotor activity J:78062
enlarged adrenocortical cells J:78062
increased circulating adrenocorticotropin level J:78062
muscular atrophy J:78062
neonatal lethality, incomplete penetrance J:78062
postnatal growth retardation J:78062
secondary sex reversal J:78062
small adrenal glands J:78062
small testis J:78062
Cyp11a1tm2Bcc/Cyp11a1tm2Bcc
Not Specified 		abnormal adrenal cortex morphology J:133007
abnormal adrenal gland morphology J:133007
abnormal adrenal gland physiology J:133007
abnormal adrenal gland zona fasciculata morphology J:133007
abnormal adrenal gland zona glomerulosa morphology J:133007
abnormal circulating hormone level J:133007
abnormal mitochondrial morphology J:133007
decreased circulating corticosterone level J:133007
decreased survivor rate J:133007
decreased T cell apoptosis J:133007
enlarged adrenal glands J:133007
normal reproductive system phenotype J:133007
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory