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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
MGI:88586
29 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cyp17a1tm1b(EUCOMM)Wtsi/Cyp17a1tm1b(EUCOMM)Wtsi
C57BL/6N-Cyp17a1tm1b(EUCOMM)Wtsi/Nju 		abnormal auditory brainstem response J:211773
abnormal bone structure J:211773
abnormal male genitalia morphology J:211773
abnormal vocalization J:211773
absent external male genitalia J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased circulating phosphate level J:211773
decreased grip strength J:211773
decreased heart weight J:211773
decreased lean body mass J:211773
decreased locomotor activity J:211773
improved glucose tolerance J:211773
increased blood urea nitrogen level J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating cholesterol level J:211773
increased circulating creatinine level J:211773
increased circulating HDL cholesterol level J:211773
increased fasting circulating glucose level J:211773
increased total body fat amount J:211773
Cyp17a1tm1Mell/Cyp17a1tm1Mell
involves: 129X1/SvJ * C57BL/6 		embryonic lethality between implantation and somite formation, complete penetrance J:91081
Cyp17a1tm1Vpap/Cyp17a1+
chimera involves: 129X1/SvJ * C57BL/6 		abnormal sexual interaction J:100434
abnormal sperm flagellum morphology J:100434
abnormal testosterone level J:100434
asthenozoospermia J:100434
decreased circulating testosterone level J:100434
early reproductive senescence J:100434
reduced male fertility J:100434
transmission ratio distortion J:100434
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory