Cyp1a1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
MGI:88588

22 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cyp1a1^tm1.1Dwn/Cyp1a1^tm1.1Dwn B6.129P2-Cyp1a1^tm1.1Dwn	abnormal hemoglobin content	J:163973
	abnormal liver physiology	J:88957
	abnormal xenobiotic pharmacokinetics	J:163973
	decreased hematocrit	J:163973
	decreased lymphocyte cell number	J:163973
	decreased physiological sensitivity to xenobiotic	J:89337
	decreased spleen weight	J:163973
	decreased susceptibility to xenobiotic induced morbidity/mortality	J:89337
	decreased thymus weight	J:163973
	increased circulating alanine transaminase level	J:163973
	increased circulating aspartate transaminase level	J:163973
	increased hemoglobin content	J:163973
	increased liver weight	J:163973
	increased neutrophil cell number	J:163973
	increased physiological sensitivity to xenobiotic	J:147150, J:163973
	increased susceptibility to weight loss	J:163973
Cyp1a1^tm1.1Dwn/Cyp1a1^tm1.1Dwn involves: 129P2/OlaHsd * C57BL/6	decreased leukocyte cell number	J:122409
	enlarged liver	J:122409
	increased circulating alanine transaminase level	J:122409
	increased circulating aspartate transaminase level	J:122409
	small spleen	J:122409
	small thymus	J:122409
Cyp1a1^tm1.1Dwn/Cyp1a1^tm1.1Dwn involves: 129P2/OlaHsd * C57BL/6J	no abnormal phenotype detected	J:59398
Cyp1a1^tm2.1Dwn/Cyp1a1^tm2.1Dwn B6.129X1-Cyp1a1^tm2.1Dwn	normal homeostasis/metabolism phenotype	J:163973
Cyp1a1^tm3.1Dwn/Cyp1a1^tm3.1Dwn B6.129X1-Cyp1a1^tm3.1Dwn	increased physiological sensitivity to xenobiotic	J:163973
Cyp1a1^tm4.1Dwn/Cyp1a1^tm4.1Dwn B6.129X1-Cyp1a1^tm4.1Dwn	abnormal hemoglobin content	J:163973
	abnormal xenobiotic pharmacokinetics	J:163973
	decreased hematocrit	J:163973
	decreased lymphocyte cell number	J:163973
	decreased spleen weight	J:163973
	decreased thymus weight	J:163973
	increased circulating alanine transaminase level	J:163973
	increased circulating aspartate transaminase level	J:163973
	increased hemoglobin content	J:163973
	increased liver weight	J:163973
	increased neutrophil cell number	J:163973
	increased physiological sensitivity to xenobiotic	J:163973
	increased susceptibility to weight loss	J:163973

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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