Xrn1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Xrn1
5'-3' exoribonuclease 1
MGI:891964

27 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Xrn1^em1.1Tya/Xrn1^em1.1Tya involves: C57BL/6 * C57BL/6N	embryonic growth retardation	J:342928
	embryonic lethality during organogenesis, complete penetrance	J:342928
	open neural tube	J:342928
Xrn1^em1Tya/Xrn1^em1Tya Tg(Camk2a-cre)2Gsc/0 involves: C57BL/6N * FVB/N	abnormal brown adipose tissue thermogenesis	J:342928
	abnormal hypothalamus physiology	J:342928
	abnormal lipid metabolism	J:342928
	abnormal liver morphology	J:342928
	abnormal locomotor behavior	J:342928
	decreased body weight	J:342928
	decreased brain weight	J:342928
	decreased response to leptin	J:342928
	impaired glucose tolerance	J:342928
	increased body length	J:342928
	increased body weight	J:342928
	increased brown adipose tissue amount	J:342928
	increased circulating glucose level	J:342928
	increased circulating insulin level	J:342928
	increased circulating leptin level	J:342928
	increased epididymal fat pad weight	J:342928
	increased food intake	J:342928
	increased inguinal fat pad weight	J:342928
	increased liver weight	J:342928
	increased respiratory quotient	J:342928
	increased white adipose tissue amount	J:342928
	increased white fat cell size	J:342928
	insulin resistance	J:342928
	obese	J:342928

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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