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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bhlha15
basic helix-loop-helix family, member a15
MGI:891976
33 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bhlha15tm1Skz/Bhlha15tm1Skz
B6.129S6-Bhlha15tm1Skz 		abnormal gastric chief cell morphology J:90459
abnormal pancreatic acinar cell zymogen granule morphology J:90459
abnormal parotid gland acinus morphology J:90459
abnormal seminal vesicle development J:130791
abnormal seminal vesicle epithelium morphology J:130791
abnormal seminal vesicle fluid composition J:130791
abnormal stomach glandular epithelium morphology J:90459
normal reproductive system phenotype J:130791
seminal vesicle epithelium degeneration J:130791
Bhlha15tm1Skz/Bhlha15tm1Skz
involves: 129S6/SvEvTac 		abnormal exocrine pancreas morphology J:72798
abnormal pancreas morphology J:72798
abnormal pancreatic acinar cell morphology J:72798
abnormal pancreatic acinar cell zymogen granule morphology J:72798
exocrine pancreatic insufficiency J:72798
pancreas fibrosis J:72798
Bhlha15tm1Skz/Bhlha15tm1Skz
involves: 129S6/SvEvTac * C57BL/6 		abnormal mammary gland alveolus morphology J:112027
abnormal mammary gland epithelium physiology J:112027
abnormal mammary gland growth during lactation J:112027
abnormal mammary gland luminal epithelium morphology J:112027
abnormal pancreatic acinar cell morphology J:85104
normal endocrine/exocrine gland phenotype J:112027
increased mammary gland apoptosis J:112027
Bhlha15tm2(Kras)Skz/Bhlha15+
involves: 129S6/SvEvTac * C57BL/6 		abnormal exocrine pancreas morphology J:105076
cachexia J:105076
enlarged liver J:105076
hemorrhagic ascites J:105076
increased hepatocellular carcinoma incidence J:105076
increased liver adenoma incidence J:105076
increased pancreas adenoma incidence J:105076
increased pancreatic acinar cell carcinoma incidence J:105076
increased tumor incidence J:105076
pancreatic acinar hyperplasia J:105076
premature death J:105076
Bhlha15tm3(cre/ERT2)Skz/Bhlha15tm3(cre/ERT2)Skz
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal autophagy J:239144
abnormal pancreatic acinar cell morphology J:239144
abnormal pancreatic acinar cell physiology J:239144
abnormal pancreatic acinar cell zymogen granule morphology J:239144
decreased pancreatic amylase secretion J:239144
Bhlha15tm3(cre/ERT2)Skz/Bhlha15tm3(cre/ERT2)Skz
Tg(CAG-Bhlha15)1Skz/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal endocrine/exocrine gland phenotype J:239144
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory