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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tcof1
treacle ribosome biogenesis factor 1
MGI:892003
106 phenotypes from 1 allele in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tcof1tm1Mjd/Tcof1+
involves: 129S1/Sv * 129X1/SvJ * BALB/c 		normal behavior/neurological phenotype J:89223
normal embryo phenotype J:89223
exencephaly J:89223
normal limbs/digits/tail phenotype J:89223
normal mortality/aging J:89223
normal nervous system phenotype J:89223
normal reproductive system phenotype J:89223
normal skeleton phenotype J:89223
normal vision/eye phenotype J:89223
Tcof1tm1Mjd/Tcof1+
involves: 129S1/Sv * 129X1/SvJ * C3H/HeN 		abnormal posture J:89223
normal craniofacial phenotype J:89223
normal embryo phenotype J:89223
exencephaly J:89223
exophthalmos J:89223
normal growth/size/body region phenotype J:89223
normal limbs/digits/tail phenotype J:89223
normal nervous system phenotype J:89223
normal skeleton phenotype J:89223
small orbits J:89223
Tcof1tm1Mjd/Tcof1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cranial ganglia morphology J:62928, J:89223
abnormal craniofacial bone morphology J:62928
abnormal craniofacial development J:62928
abnormal craniofacial morphology J:62928
abnormal cranium morphology J:62928
abnormal digit morphology J:89223
abnormal dorsal root ganglion morphology J:89223
abnormal forebrain development J:62928
abnormal forebrain morphology J:62928
abnormal lateral nasal prominence morphology J:62928
abnormal maxillary prominence morphology J:62928
abnormal medial nasal prominence morphology J:62928
abnormal midbrain development J:62928
abnormal middle ear ossicle morphology J:62928
abnormal nasal capsule morphology J:62928
abnormal nasal septum morphology J:89223
abnormal neural crest cell migration J:89223
abnormal neural fold formation J:62928
abnormal neurocranium morphology J:62928
abnormal outer ear morphology J:62928
abnormal posture J:89223
abnormal Rathke's pouch development J:62928
abnormal trigeminal nerve morphology J:62928
abnormal tympanic ring morphology J:62928
abnormal upper lip morphology J:62928
abnormal zygomatic arch morphology J:62928
absent frontal bone J:62928
absent glossopharyngeal nerve J:62928
absent interparietal bone J:62928
absent nasal pit J:62928
absent optic vesicle J:62928
absent parietal bone J:62928
acrania J:62928
anophthalmia J:62928, J:89223
cup-shaped ears J:62928
delayed embryo turning J:62928
delayed neural tube closure J:62928
disorganized dorsal root ganglion J:62928
embryonic growth retardation J:62928
exencephaly J:62928, J:89223
facial bone hypoplasia J:89223
failure of palatal shelf elevation J:62928
first pharyngeal arch hypoplasia J:62928
frontonasal prominence hypoplasia J:62928
increased neural tube apoptosis J:62928
lowered ear position J:62928
mandible hypoplasia J:62928
middle ear ossicle hypoplasia J:62928
neonatal lethality, complete penetrance J:62928
open neural tube J:62928
prenatal growth retardation J:89223
respiratory failure J:62928
retrognathia J:62928
rib fusion J:89223
short mandible J:62928
normal skeleton phenotype J:89223
small mandible J:62928
small otic vesicle J:62928
small trigeminal ganglion J:62928
tympanic ring hypoplasia J:62928
vertebral fusion J:89223
zygomatic arch hypoplasia J:62928
Tcof1tm1Mjd/Tcof1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1 		abnormal cranial ganglia morphology J:112900
abnormal cranial neural crest cell migration J:112900
abnormal craniofacial morphology J:112900
abnormal frontal bone morphology J:112900
abnormal maxilla morphology J:112900
abnormal nasal bone morphology J:112900
abnormal nasal cavity morphology J:112900
abnormal neural plate morphology J:112900
abnormal neurocranium morphology J:112900
abnormal palatal shelf fusion at midline J:112900
abnormal palatine bone morphology J:112900
abnormal premaxilla morphology J:112900
abnormal temporal bone morphology J:112900
abnormal viscerocranium morphology J:112900
absent nasal septum J:112900
absent turbinates J:112900
cleft palate J:112900
decreased cranial neural crest cell proliferation J:112900
decreased embryonic neuroepithelial cell proliferation J:112900
decreased neural crest cell number J:112900
distended abdomen J:112900
domed cranium J:112900
frontal bone hypoplasia J:112900
increased embryonic neuroepithelium apoptosis J:112900
mandible hypoplasia J:112900
maxilla hypoplasia J:112900
microcephaly J:112900
nasal bone hypoplasia J:112900
neonatal lethality, complete penetrance J:112900
palatine bone hypoplasia J:112900
premaxilla hypoplasia J:112900
respiratory distress J:112900
respiratory failure J:112900
short maxilla J:112900
short premaxilla J:112900
shortened head J:112900
temporal bone hypoplasia J:112900
Tcof1tm1Mjd/Tcof1+
involves: 129S1/Sv * 129X1/SvJ * CBA/Ca 		abnormal cranial ganglia morphology J:89223
abnormal digit morphology J:89223
abnormal dorsal root ganglion morphology J:89223
abnormal eye morphology J:89223
abnormal nasal septum morphology J:89223
abnormal neural crest cell migration J:89223
abnormal posture J:89223
delayed endochondral bone ossification J:89223
exencephaly J:89223
facial bone hypoplasia J:89223
prenatal growth retardation J:89223
rib fusion J:89223
vertebral fusion J:89223
Tcof1tm1Mjd/Tcof1+
involves: 129S1/Sv * 129X1/SvJ * DBA/1 		normal behavior/neurological phenotype J:89223
normal embryo phenotype J:89223
exencephaly J:89223
normal limbs/digits/tail phenotype J:89223
normal mortality/aging J:89223
normal nervous system phenotype J:89223
normal reproductive system phenotype J:89223
normal skeleton phenotype J:89223
normal vision/eye phenotype J:89223
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory