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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sfrp4
secreted frizzled-related protein 4
MGI:892010
26 phenotypes from 4 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sfrp4tm1.1Blan/Sfrp4+
Not Specified 		abnormal bone mineralization J:234467
decreased compact bone thickness J:234467
increased trabecular bone volume J:234467
Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
involves: C57BL/6 		decreased litter size J:173962
normal growth/size/body region phenotype J:173962
normal homeostasis/metabolism phenotype J:173962
reduced female fertility J:173962
Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Not Specified 		abnormal bone mineralization J:234467
abnormal bone ossification J:234467
abnormal bone remodeling J:234467
abnormal long bone metaphysis morphology J:234467
decreased bone strength J:234467
decreased compact bone thickness J:234467
decreased femur compact bone thickness J:234467
increased bone ossification J:234467
increased bone resorption J:234467
increased diameter of long bones J:234467
increased osteoclast cell number J:234467
increased trabecular bone volume J:234467
Sfrp4tm1.1Boer/Sfrp4tm1.1Boer
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ 		abnormal ovarian folliculogenesis J:275639
increased litter size J:275639
increased mature ovarian follicle number J:275639
normal reproductive system phenotype J:275639
Sfrp4tm1.1Lex/Sfrp4+
Not Specified 		abnormal bone mineralization J:234467
decreased compact bone thickness J:234467
increased trabecular bone volume J:234467
Sfrp4tm1.1Lex/Sfrp4tm1.1Lex
Not Specified 		abnormal bone mineralization J:234467
abnormal bone ossification J:234467
abnormal bone remodeling J:234467
abnormal long bone metaphysis morphology J:234467
decreased bone strength J:234467
decreased compact bone thickness J:234467
decreased femur compact bone thickness J:234467
increased bone ossification J:234467
increased bone resorption J:234467
increased diameter of long bones J:234467
increased osteoclast cell number J:234467
increased trabecular bone volume J:234467
Sfrp4tm1Maki/Sfrp4tm1Maki
Not Specified 		decreased bone trabecular spacing J:256184
decreased compact bone mass J:256184
decreased compact bone thickness J:256184
decreased susceptibility to osteoporosis J:256184
increased bone trabecula number J:256184
increased trabecular bone connectivity density J:256184
increased trabecular bone mass J:256184
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory