Spib Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Spib
Spi-B transcription factor (Spi-1/PU.1 related)
MGI:892986

10 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Spi1^tm1Sing/Spi1⁺ Spib^tm1Mcs/Spib⁺ involves: 129S/SvEv * 129X1/SvJ	abnormal spleen germinal center morphology	J:88257
	decreased B cell proliferation	J:88257
	normal hematopoietic system phenotype	J:88257
Spi1^tm1Sing/Spi1⁺ Spib^tm1Mcs/Spib^tm1Mcs involves: 129S/SvEv * 129X1/SvJ	abnormal B cell differentiation	J:88257
	abnormal immature B cell morphology	J:88257
	absent spleen germinal center	J:88257
	decreased B cell number	J:88257
	decreased B cell proliferation	J:88257
	normal immune system phenotype	J:88257
	increased B cell apoptosis	J:88257
Spi1^tm1Sing/Spi1^tm1Sing Spib^tm1Mcs/Spib^tm1Mcs involves: 129S/SvEv * 129X1/SvJ	lethality throughout fetal growth and development, complete penetrance	J:88257

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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