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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dok1
docking protein 1
MGI:893587
19 phenotypes from 2 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Dok1tm1Ppp/Dok1tm1Ppp
129S1/Sv-Dok1tm1Ppp 		abnormal bone marrow cell morphology/development J:95640
abnormal T cell proliferation J:95640
increased fibroblast proliferation J:95640
increased lung adenocarcinoma incidence J:158011
Dok1tm1Yyam/Dok1tm1Yyam
B6.129S4-Dok1tm1Yyam 		decreased body weight J:133566
decreased brown adipose tissue mass J:133566
decreased circulating insulin level J:133566
decreased circulating leptin level J:133566
decreased epididymal fat pad weight J:133566
decreased fat cell size J:133566
decreased inguinal fat pad weight J:133566
decreased percent body fat/body weight J:133566
decreased susceptibility to weight gain J:133566
improved glucose tolerance J:133566
increased circulating adiponectin level J:133566
increased insulin sensitivity J:133566
increased oxygen consumption J:133566
Dok1tm1Yyam/Dok1tm1Yyam
involves: 129S4/SvJae * C57BL/6 		decreased IgM level J:95641
increased B cell proliferation J:95641
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory