Dok1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dok1
docking protein 1
MGI:893587

28 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Dok1^tm1Ppp/Dok1⁺ Tg(Tec-BCR/ABL1)5Hhi/0 involves: 129S1/Sv	increased leukemia incidence	J:95334
Dok1^tm1Ppp/Dok1⁺ Tg(Tec-BCR/ABL1)5Hhi/0 involves: 129S1/Sv	premature death	J:95334
Dok1^tm1Ppp/Dok1^tm1Ppp Dok2^tm1Ppp/Dok2^tm1Ppp 129S1/Sv-Dok1^tm1Ppp Dok2^tm1Ppp	abnormal leukocyte physiology	J:95334
	enlarged spleen	J:95334
	increased bone marrow cell number	J:95334
	increased leukemia incidence	J:95334
	increased leukocyte cell number	J:95334
	increased lung adenocarcinoma incidence	J:158011
	increased monocyte cell number	J:95334
	increased neutrophil cell number	J:95334
Dok1^tm1Ppp/Dok1^tm1Ppp Dok2^tm1Ppp/Dok2^tm1Ppp Dok3^tm1Ppp/Dok3^tm1Ppp 129S1/Sv-Dok1^tm1Ppp Dok2^tm1Ppp Dok3^tm1Ppp	abnormal pulmonary alveolus morphology	J:158011
	increased bronchioalveolar stem cell number	J:158011
	increased chronic myelocytic leukemia incidence	J:158011
	increased leukocyte cell number	J:158011
	increased lung adenocarcinoma incidence	J:158011
	increased lung tumor incidence	J:158011
	increased type II pneumocyte number	J:158011
	premature death	J:158011
	pulmonary hyperplasia	J:158011
Dok1^tm1Ppp/Dok1^tm1Ppp Dok3^tm1Ppp/Dok3^tm1Ppp 129S1/Sv-Dok1^tm1Ppp Dok3^tm1Ppp	increased lung adenocarcinoma incidence	J:158011
Dok1^tm1Ppp/Dok1^tm1Ppp Tg(Tec-BCR/ABL1)5Hhi/0 involves: 129S1/Sv	increased leukemia incidence	J:95334
	premature death	J:95334
Dok1^tm1Yyam/Dok1^tm1Yyam Dok2^tm1Yyam/Dok2^tm1Yyam B6.129-Dok1^tm1Yyam Dok2^tm1Yyam	abnormal leukocyte physiology	J:95335
	abnormal myelopoiesis	J:95335
	enlarged spleen	J:95335
	extramedullary hematopoiesis	J:95335
	increased erythroblast number	J:95335
	increased leukemia incidence	J:95335
	increased leukocyte cell number	J:95335
	increased megakaryocyte cell number	J:95335
	increased monocyte cell number	J:95335
	increased neutrophil cell number	J:95335
	increased sarcoma incidence	J:95335
Dok1^tm1Yyam/Dok1^tm1Yyam Dok2^tm1Yyam/Dok2^tm1Yyam involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	abnormal macrophage physiology	J:163407
Dok1^tm1Yyam/Dok1^tm1Yyam Dok2^tm1Yyam/Dok2^tm1Yyam Dok3^tm1Brs/Dok3^tm1Brs involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	abnormal macrophage physiology	J:163407
	increased histiocytic sarcoma incidence	J:163407
	increased macrophage cell number	J:163407
	increased tumor incidence	J:163407
	premature death	J:163407
Dok1^tm1Yyam/Dok1^tm1Yyam Dok2^tm1Yyam/Dok2^tm1Yyam Tg(Tec-BCR/ABL1)5Hhi/0 involves: C57BL/6	enlarged lymph nodes	J:95335
	enlarged thymus	J:95335
	increased leukemia incidence	J:95335
	premature death	J:95335
Dok1^tm1Yyam/Dok1^tm1Yyam Pparg^tm1Laz/Pparg^tm1Laz involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	abnormal fat cell morphology	J:133566
	normal adipose tissue phenotype	J:133566
Dok1^tm1Yyam/Dok1^tm1Yyam Tg(Tec-BCR/ABL1)5Hhi/0 involves: C57BL/6	enlarged lymph nodes	J:95335
	enlarged thymus	J:95335
	increased leukemia incidence	J:95335
	premature death	J:95335

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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