Aurka Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Aurka
aurora kinase A
MGI:894678

51 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Aurka^{Gt(XQ0149)Wtsi}/Aurka⁺ involves: 129P2/OlaHsd * C57BL/6	aneuploidy	J:143099
	chromosomal instability	J:143099
	increased hepatoma incidence	J:143099
	increased lung carcinoma incidence	J:143099
	increased lymphoma incidence	J:143099
	increased squamous cell carcinoma incidence	J:143099
	increased tumor incidence	J:143099
Aurka^{Gt(XQ0149)Wtsi}/Aurka^{Gt(XQ0149)Wtsi} involves: 129P2/OlaHsd * C57BL/6	abnormal mitosis	J:143099
	abnormal mitotic spindle morphology	J:143099
	embryonic growth arrest	J:143099
	embryonic lethality before implantation	J:143099
Aurka^tm1.1Tvd/Aurka^tm1.1Tvd Ccn6^tm1(cre)Mawa/Ccn6⁺ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J	abnormal sperm head morphology	J:321647
	abnormal sperm midpiece morphology	J:321647
	abnormal sperm motility	J:321647
	abnormal sperm physiology	J:321647
	decreased litter size	J:321647
	decreased testis weight	J:321647
	increased male germ cell apoptosis	J:321647
	increased sperm progressive motility	J:321647
	kinked sperm flagellum	J:321647
	multiflagellated sperm	J:321647
	oligozoospermia	J:321647
	reduced male fertility	J:321647
	small testis	J:321647
	teratozoospermia	J:321647
Aurka^tm1.1Tvd/Aurka^tm1.1Tvd Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ involves: 129 * 129P2/OlaHsd * C57BL/6J	abnormal mitosis	J:145744
	increased apoptosis	J:145744
	increased mitotic index	J:145744
Aurka^tm1.1Tvd/Aurka^tm1.1Tvd Tg(Ddx4-cre)1Dcas/0 involves: 129P2/OlaHsd * C57BL/6J * FVB	abnormal cauda epididymis morphology	J:321647
	abnormal seminiferous tubule epithelium morphology	J:321647
	abnormal seminiferous tubule morphology	J:321647
	absent germ cells	J:321647
	azoospermia	J:321647
	decreased testis weight	J:321647
	small testis	J:321647
Aurka^tm1.2Sbsn/Aurka^tm1.2Sbsn involves: 129S7/SvEvBrd * C57BL/6	abnormal cell nucleus morphology	J:198479
	abnormal inner cell mass morphology	J:198479
	abnormal mitosis	J:198479
	abnormal mitotic spindle morphology	J:198479
	decreased embryo size	J:198479
	embryonic growth retardation	J:198479
	embryonic lethality, complete penetrance	J:198479
	inner cell mass degeneration	J:198479
Aurka^tm1.2Tvd/Aurka^tm1.2Tvd involves: 129P2/OlaHsd * C57BL/6J	abnormal mitotic spindle morphology	J:145744
	abnormal preimplantation embryo development	J:145744
	embryonic lethality before implantation, complete penetrance	J:145744
	failure of blastocyst to hatch from the zona pellucida	J:145744
	increased mitotic index	J:145744
Aurka^{tm1b(EUCOMM)Hmgu}/Aurka⁺ B6N(Cg)-Aurka^{tm1b(EUCOMM)Hmgu}/J	abnormal bone structure	J:211773
	decreased leukocyte cell number	J:211773
	sclerocornea	J:211773
Aurka^{tm1b(EUCOMM)Hmgu}/Aurka^{tm1b(EUCOMM)Hmgu} B6N(Cg)-Aurka^{tm1b(EUCOMM)Hmgu}/J	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Aurka^{tm1c(EUCOMM)Hmgu}/Aurka^{tm1c(EUCOMM)Hmgu} Tg(Gdf9-icre)5092Coo/0 involves: C57BL/6 * C57BL/6J * C57BL/6N	abnormal female meiosis I arrest	J:307094
	abnormal meiotic spindle morphology	J:307094
	decreased corpora lutea number	J:307094
	female infertility	J:307094

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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