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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bach2
BTB and CNC homology, basic leucine zipper transcription factor 2
MGI:894679
81 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bach2M1Btlr/Bach2M1Btlr
C57BL/6J-Bach2M1Btlr 		decreased CD4-positive, alpha-beta T cell number J:272023
increased B-1 B cell number J:272023
Bach2m1Ccg/Bach2m1Ccg
C57BL/6-Bach2m1Ccg 		decreased B cell number J:94077
decreased marginal zone B cell number J:94077
myeloid hyperplasia J:94077
Bach2m2Anu/Bach2m2Anu
C57BL/6NCrlAnu-Bach2m2Anu 		decreased mature B cell number J:104190
increased IgM level J:104190
increased immature B cell number J:104190
Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi 		abnormal bone structure J:211773
decreased B cell number J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased CD8-positive, naive alpha-beta T cell number J:211773
decreased CD11b-high dendritic cell number J:211773
decreased circulating creatinine level J:211773
decreased effector memory CD8-positive, alpha-beta T cell number J:211773
decreased follicular B cell number J:211773
decreased mature B cell number J:211773
decreased memory-marker NK cell number J:211773
decreased regulatory T cell number J:211773
increased CD4-positive, alpha-beta memory T cell number J:211773
increased CD8-positive, alpha-beta memory T cell number J:211773
increased CD11b-low dendritic cell number J:211773
increased CD103-positive CD11b-low dendritic cell number J:211773
increased circulating iron level J:211773
increased effector memory CD8-positive, alpha-beta T cell number J:211773
increased effector memory T-helper cell number J:211773
increased eosinophil cell number J:211773
increased immature B cell number J:211773
increased KLRG1+ CD4 alpha-beta T cell number J:211773
increased KLRG1+ CD8 alpha-beta T cell number J:211773
increased KLRG1-positive CD4-negative NK T cell number J:211773
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:211773
increased KLRG1-positive gamma-delta T cell number J:211773
increased KLRG1-positive NK cell number J:211773
increased Ly6C high monocyte number J:211773
increased Ly6C low monocyte number J:211773
increased macrophage cell number J:211773
increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:211773
increased memory-marker CD4-negative NK T cell number J:211773
increased memory-marker NK cell number J:211773
increased monocyte cell number J:211773
increased neutrophil cell number J:211773
increased NK cell number J:211773
thrombocytosis J:211773
Bach2tm1b(EUCOMM)Wtsi/Bach2tm1b(EUCOMM)Wtsi
C57BL/6N-Bach2tm1b(EUCOMM)Wtsi/Ieg 		abnormal optic disk morphology J:211773
decreased B cell number J:211773
decreased B-1a cell number J:211773
decreased B-2 B cell number J:211773
decreased bone mineral density J:211773
decreased CD4-negative NK T cell number J:211773
decreased CD8-positive, naive alpha-beta T cell number J:211773
decreased CD11b-high dendritic cell number J:211773
decreased circulating creatinine level J:211773
decreased circulating glucose level J:211773
decreased exploration in new environment J:211773
decreased follicular B cell number J:211773
decreased food intake J:211773
decreased Ly6C-positive immature NK cell number J:211773
decreased Ly6C-positive mature NK cell number J:211773
decreased marginal zone B cell number J:211773
decreased memory-marker CD4-negative NK T cell number J:211773
decreased NK T cell number J:211773
decreased prepulse inhibition J:211773
decreased respiratory quotient J:211773
decreased transitional stage B cell number J:211773
decreased vertical activity J:211773
hyperactivity J:211773
immune system phenotype J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating amylase level J:211773
increased circulating aspartate transaminase level J:211773
increased circulating unsaturated transferrin level J:211773
increased effector memory CD8-positive, alpha-beta T cell number J:211773
increased eosinophil cell number J:211773
increased granulocyte number J:211773
increased grip strength J:211773
increased memory-marker CD4-negative NK T cell number J:211773
increased monocyte cell number J:211773
increased NK T cell number J:211773
increased pulmonary respiratory rate J:211773
limb grasping J:211773
short tibia J:211773
Bach2tm1Igar/Bach2tm1Igar
involves: 129P2/OlaHsd * C57BL/6J 		abnormal B cell differentiation J:91110
abnormal B cell physiology J:91110
abnormal class switch recombination J:91110
abnormal somatic hypermutation frequency J:91110
absent germinal center B cells J:91110
decreased B cell number J:91110
decreased IgA level J:91110
decreased IgG1 level J:91110
decreased IgG2a level J:91110
decreased IgG2b level J:91110
decreased IgG3 level J:91110
decreased IgG level J:91110
decreased mature B cell number J:91110
increased IgM level J:91110
spleen hypoplasia J:91110
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory