Sgca Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sgca
sarcoglycan, alpha (dystrophin-associated glycoprotein)
MGI:894698

24 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sgca^tm1Eeng/Sgca^tm1Eeng involves: 129S/SvEv * 129X1/SvJ	impaired skeletal muscle contractility	J:83034
Sgca^tm1Isrd/Sgca^tm1Isrd involves: 129S2/SvPas * BALB/c * C57BL/6	normal muscle phenotype	J:133929
Sgca^tm1Kcam/Sgca^tm1Kcam involves: 129S1/Sv * 129X1/SvJ	abnormal circulating pyruvate kinase level	J:49992
	abnormal muscle contractility	J:49992
	abnormal muscle fiber morphology	J:49992
	abnormal sarcolemma morphology	J:49992
	abnormal skeletal muscle fiber morphology	J:133929
	calcified muscle	J:49992
	cardiac fibrosis	J:177563
	cardiac muscle necrosis	J:177563
	cardiomyopathy	J:177563
	centrally nucleated skeletal muscle fibers	J:49992
	dystrophic muscle	J:49992
	heart inflammation	J:177563
	increased circulating creatine kinase level	J:49992, J:130252
	increased extensor digitorum longus weight	J:49992
	increased soleus weight	J:49992
	normal muscle phenotype	J:177563
Sgca^tm2Kcam/Sgca^tm2Kcam B6.129S6-Sgca^tm2Kcam/J	abnormal muscle physiology	J:250485
	abnormal skeletal muscle morphology	J:250485
	decreased grip strength	J:250485
	decreased pulmonary respiratory rate	J:250485
	dystrophic muscle	J:250485
	increased circulating creatine kinase level	J:250485
	skeletal muscle fibrosis	J:250485
Sgca^tm2Kcam/Sgca^tm2Kcam either: (129S6/SvEvTac-Sgca^tm2Kcam) or (involves: 129S6/SvEvTac * C57BL/6J)	abnormal muscle contractility	J:130252
	abnormal muscle fiber morphology	J:130252
	abnormal sarcolemma morphology	J:130252
	calcified muscle	J:130252
	dystrophic muscle	J:130252
	increased circulating creatine kinase level	J:130252
	increased muscle weight	J:130252
Sgca^tm2Kcam/Sgca^tm2Kcam Tg(Ckmm-cre)5Khn/0 either: (involves: 129S4/SvJae * 129S6/SvEvTac * FVB) or (involves: 129S6/SvEvTac * C57BL/6J * FVB)	normal homeostasis/metabolism phenotype	J:130252
	normal muscle phenotype	J:130252

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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