Dbh Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dbh
dopamine beta hydroxylase
MGI:94864

22 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dbh^{tm1(flpo)Pjen}/Dbh⁺ involves: 129S7/SvEvBrd * C57BL/6J	no abnormal phenotype detected	J:198264
Dbh^{tm1(flpo)Pjen}/Dbh^{tm1(flpo)Pjen} involves: 129S7/SvEvBrd * C57BL/6J	embryonic lethality during organogenesis	J:198264
	prenatal lethality, complete penetrance	J:198264
Dbh^tm1Rpa/Dbh^tm1Rpa either: (involves: 129S7/SvEvBrd * 129/SvCpj) or (involves: 129S7/SvEvBrd * C57BL/6J)	abnormal heart morphology	J:24414
	absent circulating adrenaline	J:24414
	absent circulating noradrenaline	J:24414
	blepharoptosis	J:24414
	decreased body size	J:24414
	embryonic lethality during organogenesis, incomplete penetrance	J:24414
	increased circulating corticosterone level	J:97566
	increased dopamine level	J:24414
	neonatal lethality, incomplete penetrance	J:24414
	postnatal growth retardation	J:24414
	premature death	J:24414
Dbh^tm1Rpa/Dbh^tm1Rpa involves: 129S7/SvEvBrd * 129/SvCPJ * C57BL/6J	abnormal food intake	J:85772
	abnormal glucose homeostasis	J:85772
	decreased circulating glucagon level	J:85772
	decreased circulating glucose level	J:85772
	decreased glucagon secretion	J:85772
	increased circulating corticosterone level	J:85772
	increased circulating insulin level	J:85772
	insulin resistance	J:85772
Dbh^tm2(Th)Rpa/Dbh^tm2(Th)Rpa Not Specified	embryonic lethality during organogenesis, incomplete penetrance	J:30404
	postnatal growth retardation	J:30404
	postnatal lethality	J:30404

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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