Dbi Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dbi
diazepam binding inhibitor
MGI:94865

16 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dbi^tm1Kier/Dbi^tm1Kier B6NCr.129S6-Dbi^tm1Kier	embryonic lethality, complete penetrance	J:198622
Dbi^tm1Smdp/Dbi^tm1Smdp B6JBomTac.129-Dbi^tm1Smdp	abnormal cholesterol homeostasis	J:168744
	abnormal coat/ hair morphology	J:168744
	abnormal skin morphology	J:168744
	decreased body weight	J:168744
	increased circulating cholesterol level	J:168744
	increased liver cholesterol level	J:168744
	increased liver triglyceride level	J:168744
	lethality at weaning, complete penetrance	J:168744
	postnatal growth retardation	J:168744
	weakness	J:168744
Dbi^tm1Smdp/Dbi^tm1Smdp involves: 129S1/Sv * 129X1/SvJ	abnormal liver physiology	J:204137
	abnormal white adipose tissue physiology	J:204137
	increased liver cholesterol level	J:204137
	increased liver triglyceride level	J:204137
Dbi^tm2.1Smdp/Dbi^tm2.2Smdp Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: C57BL/6 * DBA * FVB/N	no abnormal phenotype detected	J:204137
Dbi^tm2.1Smdp/Dbi^tm2.2Smdp Tg(KRT14-cre)1Cgn/0 involves: C57BL/6 * DBA/2 * FVB/N	abnormal liver physiology	J:204137
	abnormal white adipose tissue physiology	J:204137
	greasy coat	J:204137
	impaired skin barrier function	J:204137
	increased liver cholesterol level	J:204137

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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