Dcc Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dcc
DCC netrin 1 receptor
MGI:94869

33 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apc^Min/Apc⁺ Dcc^tm1Wbg/Dcc⁺ involves: C57BL/6J	increased intestinal adenoma incidence	J:39765
Apc^tm1Rak/Apc⁺ Dcc^tm1.1Mehl/Dcc^tm1.1Mehl involves: 129P2/OlaHsd * C57BL/6	increased gastrointestinal tumor incidence	J:181517
	increased intestinal adenocarcinoma incidence	J:181517
	increased metastatic potential	J:181517
Dcc^{Tg(H2-Kb-Jak2V617F)1Shmd}/Dcc⁺ involves: C57BL/6 DBA/2	abnormal definitive hematopoiesis	J:130189
	abnormal megakaryocyte morphology	J:130189
	abnormal neutrophil morphology	J:130189
	abnormal spleen morphology	J:130189
	decreased erythroid progenitor cell number	J:130189
	decreased hematocrit	J:130189
	decreased spleen white pulp amount	J:130189
	enhanced megakaryocyte emperipolesis	J:130189
	enlarged spleen	J:130189
	increased bone marrow cell number	J:130189
	increased erythroblast number	J:130189
	increased granulocyte number	J:130189
	increased leukocyte cell number	J:130189
	increased megakaryocyte cell number	J:130189
	increased spleen red pulp amount	J:130189
	increased spleen weight	J:130189
	myeloid hyperplasia	J:130189
	polycythemia	J:130189
	thrombocytosis	J:130189
Dcc^tm1.1Mehl/Dcc^tm1.1Mehl Not Specified	decreased enterocyte apoptosis	J:181517
	decreased fibroblast apoptosis	J:181517
	normal digestive/alimentary phenotype	J:181517
	increased intestinal adenocarcinoma incidence	J:181517
	increased intestinal adenoma incidence	J:181517
Dcc^tm1Nki/Dcc^tm1Nki Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)8Brn/? involves: 129P2/OlaHsd * FVB/N	abnormal tumor latency	J:181090
	decreased apoptosis	J:181090
	increased classified tumor incidence	J:181090
	increased mammary adenocarcinoma incidence	J:181090
	increased metastatic potential	J:181090
	increased spindle cell carcinoma incidence	J:181090
	increased tumor incidence	J:181090
Dcc^tm1Wbg/Dcc⁺ Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c⁺ involves: 129X1/SvJ * C57BL/6J * SJL/J	abnormal axon guidance	J:80430
Dcc^tm1Wbg/Dcc⁺ Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} involves: 129X1/SvJ * C57BL/6J * SJL/J	abnormal axon guidance	J:80430

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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