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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ddc
dopa decarboxylase
MGI:94876
50 phenotypes from 5 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ddcem1(IMPC)Hmgu/Ddc+
C57BL/6N-Ddcem1(IMPC)Hmgu/Ieg 		abnormal tooth morphology J:211773
decreased mean corpuscular hemoglobin concentration J:211773
Ddcem1(IMPC)Hmgu/Ddcem1(IMPC)Hmgu
C57BL/6N-Ddcem1(IMPC)Hmgu/Ieg 		preweaning lethality, complete penetrance J:211773
DdcGt(OST129277)Lex/DdcGt(OST129277)Lex
involves: 129S5/SvEvBrd * C57BL/6J 		preweaning lethality, complete penetrance J:103485
Ddctm1.1Nwlh/Ddctm1.1Nwlh
involves: C57BL/6 		abnormal dopamine level J:197646
abnormal locomotor activation J:197646
abnormal maternal nurturing J:197646
abnormal motor learning J:197646
abnormal noradrenaline level J:197646
abnormal synaptic neurotransmitter level J:197646
akinesia J:197646
blepharoptosis J:197646
decreased body size J:197646
decreased dopamine level J:197646
decreased heart rate J:197646
decreased locomotor activity J:197646
decreased serotonin level J:197646
decreased systemic arterial systolic blood pressure J:197646
delayed eyelid opening J:197646
impaired coordination J:197646
increased anxiety-related response J:197646
increased thigmotaxis J:197646
increased vertical activity J:197646
induced hyperactivity J:197646
jerky movement J:197646
limb grasping J:197646
postnatal growth retardation J:197646
prenatal lethality, incomplete penetrance J:197646
tremors J:197646
Ddctm1.1Rhrs/Ddctm1.1Rhrs
Tg(Ggt1-cre)M3Egn/0
129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn 		abnormal kidney physiology J:175630
abnormal response/metabolism to endogenous compounds J:175630
albuminuria J:175630
decreased circulating aldosterone level J:175630
decreased dopamine level J:175630
decreased renin activity J:175630
increased circulating creatinine level J:175630
increased heart weight J:175630
increased kidney weight J:175630
increased mean systemic arterial blood pressure J:175630
increased renin activity J:175630
increased systemic arterial systolic blood pressure J:175630
oxidative stress J:175630
premature death J:175630
salt-sensitive hypertension J:175630
tubulointerstitial nephritis J:175630
Ddctm1.1Rhrs/Ddctm1.1Rhrs
Tg(Ggt1-cre)M3Egn/0
involves: 129 * C57BL/6 * SJL 		abnormal kidney physiology J:175630
abnormal response/metabolism to endogenous compounds J:175630
albuminuria J:175630
decreased circulating aldosterone level J:175630
decreased dopamine level J:175630
decreased renin activity J:175630
increased circulating creatinine level J:175630
increased heart weight J:175630
increased kidney weight J:175630
increased mean systemic arterial blood pressure J:175630
increased renin activity J:175630
increased systemic arterial systolic blood pressure J:175630
oxidative stress J:175630
premature death J:175630
salt-sensitive hypertension J:175630
tubulointerstitial nephritis J:175630
Ddctm1Umon/Ddctm1Umon
B6.129S(FVB)-Ddctm1Umon 		embryonic lethality, complete penetrance J:250494
Ddctm1Umon/Ddctm1Umon
FVB.129S(B6)-Ddctm1Umon 		embryonic lethality, complete penetrance J:250494
Ddctm1Umon/Ddctm1Umon
involves: 129S/SvEv * C57BL/6 * FVB/N 		abnormal embryo development J:250494
abnormal embryonic tissue morphology J:250494
abnormal maternal nurturing J:250494
decreased dopamine level J:250494
decreased embryo size J:250494
decreased serotonin level J:250494
impaired adaptive thermogenesis J:250494
impaired coordination J:250494
lethality throughout fetal growth and development, incomplete penetrance J:250494
reduced female fertility J:250494
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory