Ddc Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ddc
dopa decarboxylase
MGI:94876

51 phenotypes from 5 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ddc^{em1(IMPC)Hmgu}/Ddc⁺ C57BL/6N-Ddc^{em1(IMPC)Hmgu}/Ieg	abnormal tooth morphology	J:211773
	decreased mean corpuscular hemoglobin concentration	J:211773
	increased mean corpuscular volume	J:211773
Ddc^{em1(IMPC)Hmgu}/Ddc^{em1(IMPC)Hmgu} C57BL/6N-Ddc^{em1(IMPC)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773
Ddc^{Gt(OST129277)Lex}/Ddc^{Gt(OST129277)Lex} involves: 129S5/SvEvBrd * C57BL/6J	preweaning lethality, complete penetrance	J:103485
Ddc^tm1.1Nwlh/Ddc^tm1.1Nwlh involves: C57BL/6	abnormal dopamine level	J:197646
	abnormal locomotor activation	J:197646
	abnormal maternal nurturing	J:197646
	abnormal motor learning	J:197646
	abnormal noradrenaline level	J:197646
	abnormal synaptic neurotransmitter level	J:197646
	akinesia	J:197646
	blepharoptosis	J:197646
	decreased body size	J:197646
	decreased dopamine level	J:197646
	decreased heart rate	J:197646
	decreased locomotor activity	J:197646
	decreased serotonin level	J:197646
	decreased systemic arterial systolic blood pressure	J:197646
	delayed eyelid opening	J:197646
	impaired coordination	J:197646
	increased anxiety-related response	J:197646
	increased thigmotaxis	J:197646
	increased vertical activity	J:197646
	induced hyperactivity	J:197646
	jerky movement	J:197646
	limb grasping	J:197646
	postnatal growth retardation	J:197646
	prenatal lethality, incomplete penetrance	J:197646
	tremors	J:197646
Ddc^tm1.1Rhrs/Ddc^tm1.1Rhrs Tg(Ggt1-cre)M3Egn/0 129.Cg-Ddc^tm1.1Rhrs Tg(Ggt1-cre)M3Egn	abnormal kidney physiology	J:175630
	abnormal response/metabolism to endogenous compounds	J:175630
	albuminuria	J:175630
	decreased circulating aldosterone level	J:175630
	decreased dopamine level	J:175630
	decreased renin activity	J:175630
	increased circulating creatinine level	J:175630
	increased heart weight	J:175630
	increased kidney weight	J:175630
	increased mean systemic arterial blood pressure	J:175630
	increased renin activity	J:175630
	increased systemic arterial systolic blood pressure	J:175630
	oxidative stress	J:175630
	premature death	J:175630
	salt-sensitive hypertension	J:175630
	tubulointerstitial nephritis	J:175630
Ddc^tm1.1Rhrs/Ddc^tm1.1Rhrs Tg(Ggt1-cre)M3Egn/0 involves: 129 * C57BL/6 * SJL	abnormal kidney physiology	J:175630
	abnormal response/metabolism to endogenous compounds	J:175630
	albuminuria	J:175630
	decreased circulating aldosterone level	J:175630
	decreased dopamine level	J:175630
	decreased renin activity	J:175630
	increased circulating creatinine level	J:175630
	increased heart weight	J:175630
	increased kidney weight	J:175630
	increased mean systemic arterial blood pressure	J:175630
	increased renin activity	J:175630
	increased systemic arterial systolic blood pressure	J:175630
	oxidative stress	J:175630
	premature death	J:175630
	salt-sensitive hypertension	J:175630
	tubulointerstitial nephritis	J:175630
Ddc^tm1Umon/Ddc^tm1Umon B6.129S(FVB)-Ddc^tm1Umon	embryonic lethality, complete penetrance	J:250494
Ddc^tm1Umon/Ddc^tm1Umon FVB.129S(B6)-Ddc^tm1Umon	embryonic lethality, complete penetrance	J:250494
Ddc^tm1Umon/Ddc^tm1Umon involves: 129S/SvEv * C57BL/6 * FVB/N	abnormal embryo development	J:250494
	abnormal embryonic tissue morphology	J:250494
	abnormal maternal nurturing	J:250494
	decreased dopamine level	J:250494
	decreased embryo size	J:250494
	decreased serotonin level	J:250494
	impaired adaptive thermogenesis	J:250494
	impaired coordination	J:250494
	lethality throughout fetal growth and development, incomplete penetrance	J:250494
	reduced female fertility	J:250494

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24