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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Des
desmin
MGI:94885
79 phenotypes from 6 alleles in 7 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Destm1.1Ccrs/Des+
involves: 129 * C57BL/6J 		abnormal heart electrocardiography waveform feature J:219616
abnormal impulse conducting system conduction J:219616
abnormal P wave J:219616
abnormal skeletal muscle fiber morphology J:219616
atrial fibrillation J:219616
atrioventricular block J:219616
cardiac fibrosis J:219616
cardiomyopathy J:219616
decreased cardiac muscle contractility J:219616
dilated cardiomyopathy J:219616
irregular heartbeat J:219616
normal muscle phenotype J:219616
prolonged HV interval J:219616
sinoatrial block J:219616
ventricular premature beat J:219616
ventricular tachycardia J:219616
Destm1.1Ccrs/Destm1.1Ccrs
involves: 129 * C57BL/6J 		abnormal heart electrocardiography waveform feature J:219616
abnormal impulse conducting system conduction J:219616
abnormal skeletal muscle fiber mitochondrial morphology J:219616
abnormal skeletal muscle fiber morphology J:219616
abnormal soleus morphology J:219616
abnormal Z line morphology J:219616
atrial fibrillation J:219616
atrioventricular block J:219616
cardiac fibrosis J:219616
cardiomyopathy J:219616
centrally nucleated skeletal muscle fibers J:219616
decreased cardiac muscle contractility J:219616
decreased cardiac stroke volume J:219616
decreased grip strength J:219616
dilated cardiomyopathy J:219616
dystrophic muscle J:219616
impaired skeletal muscle contractility J:219616
increased mitochondrial size J:219616
increased variability of skeletal muscle fiber size J:219616
irregular heartbeat J:219616
myopathy J:219616
progressive muscle weakness J:219616
prolonged HV interval J:219616
sinoatrial block J:219616
skeletal muscle degeneration J:219616
skeletal muscle endomysial fibrosis J:219616
skeletal muscle fiber degeneration J:219616
ventricular premature beat J:219616
ventricular tachycardia J:219616
Destm1Cap/Destm1Cap
involves: 129S7/SvEvBrd 		abnormal cardiovascular system physiology J:88267
abnormal heart morphology J:88267
abnormal myocardial fiber morphology J:88267
abnormal myocardial fiber physiology J:88267
cardiac fibrosis J:88267
cardiac hypertrophy J:88267
decreased heart ventricle muscle contractility J:88267
dilated cardiomyopathy J:88267
dystrophic cardiac calcinosis J:88267
Destm1Cap/Destm1Cap
involves: 129S7/SvEvBrd * C57BL/6 		abnormal cardiac muscle relaxation J:59831
abnormal myocardial fiber morphology J:35123, J:59831
abnormal myocardium layer morphology J:35123
abnormal skeletal muscle morphology J:35123
abnormal smooth muscle morphology J:35123
cardiac hypertrophy J:59831
cardiac interstitial fibrosis J:35123
cardiomyopathy J:35123
congestive heart failure J:59831
decreased heart ventricle muscle contractility J:59831
dilated heart left ventricle J:59831
dilated heart right ventricle J:59831
disorganized myocardium J:35123, J:59831
dystrophic cardiac calcinosis J:35123, J:59831
enlarged heart J:59831
impaired exercise endurance J:59831
lethargy J:35123
muscle degeneration J:35123
premature death J:59831
thin myocardium J:59831
Destm1Cba/Destm1Cba
involves: 129S2/SvPas 		abnormal aorta elastic fiber morphology J:32928
abnormal diaphragm morphology J:32928
abnormal myocardial fiber morphology J:32928
abnormal myocardium layer morphology J:32928
abnormal skeletal muscle fiber morphology J:137067
abnormal vascular smooth muscle morphology J:32928
cardiac fibrosis J:32928
centrally nucleated skeletal muscle fibers J:137067
decreased skeletal muscle fiber number J:137067
dystrophic cardiac calcinosis J:32928
hemorrhage J:32928
increased skeletal muscle fiber size J:137067
myocardium necrosis J:32928
skeletal muscle fiber atrophy J:137067
skeletal muscle fiber necrosis J:137067
thin diaphragm muscle J:32928
Destm1Cba/Destm1Cba
involves: 129S2/SvPas * C57BL/6J 		abnormal myocardial fiber physiology J:130557
cardiac fibrosis J:130557
cardiomyopathy J:130557
decreased cardiac muscle contractility J:130557
decreased left ventricle developed pressure J:130557
dystrophic cardiac calcinosis J:130557
enlarged heart J:130557
increased heart left ventricle wall thickness J:130557
increased heart left ventricle weight J:130557
increased heart weight J:130557
increased left ventricle diastolic pressure J:130557
Destm1Ltho/Destm1Ltho
involves: 129S2/SvPas * C57BL/6J * CBA 		abnormal epicardium morphology J:127515
abnormal heart morphology J:127515
abnormal heart right ventricle morphology J:127515
abnormal intercalated disk morphology J:127515
abnormal interventricular septum morphology J:127515
abnormal myocardial fiber morphology J:127515
abnormal ventricle papillary muscle morphology J:127515
cardiac fibrosis J:127515
decreased myocardial fiber number J:127515
dystrophic cardiac calcinosis J:127515
myocardial fiber degeneration J:127515
Tg(Myh6-Des)520Rbns/0
involves: FVB/N 		no abnormal phenotype detected J:108730
Tg(Myh6-Des*)641Rbns/0
involves: FVB/N 		abnormal cardiac muscle relaxation J:108730
abnormal heart echocardiography feature J:108730
abnormal myocardial fiber morphology J:108730
abnormal myocardial fiber physiology J:108730
abnormal Z line morphology J:108730
cardiac hypertrophy J:108730
decreased heart left ventricle muscle contractility J:108730
increased left ventricle diastolic pressure J:108730
increased myocardial fiber size J:108730
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory