Dhfr Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dhfr
dihydrofolate reductase
MGI:94890

24 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dhfr^orana/Dhfr⁺ involves: C57BL/6JAnu	abnormal folic acid level	J:236197
	abnormal hemopoiesis	J:236197
	decreased granulocyte monocyte progenitor cell number	J:236197
	decreased vasodilation	J:236197
	enlarged spleen	J:236197
	extramedullary hematopoiesis	J:236197
	normal homeostasis/metabolism phenotype	J:236197
Dhfr^orana/Dhfr^orana involves: C57BL/6JAnu	abnormal DNA methylation	J:236197
	abnormal folic acid level	J:236197
	decreased common myeloid progenitor cell number	J:236197
	decreased embryo size	J:236197
	decreased erythrocyte cell number	J:236197
	decreased erythroid progenitor cell number	J:236197
	decreased fetal size	J:236197
	decreased granulocyte monocyte progenitor cell number	J:236197
	increased nucleated erythrocyte cell number	J:236197
	lethality during fetal growth through weaning, complete penetrance	J:236197
	liver hypoplasia	J:236197
	pale liver	J:236197
	pallor	J:236197
Dhfr^{tm1b(EUCOMM)Wtsi}/Dhfr⁺ C57BL/6N-Dhfr^{tm1b(EUCOMM)Wtsi}/Tcp	decreased circulating creatinine level	J:211773
	decreased mean corpuscular hemoglobin	J:211773
	decreased prepulse inhibition	J:211773
Dhfr^{tm1b(EUCOMM)Wtsi}/Dhfr^{tm1b(EUCOMM)Wtsi} C57BL/6N-Dhfr^{tm1b(EUCOMM)Wtsi}/Tcp	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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