About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dmd
dystrophin, muscular dystrophy
MGI:94909
128 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Barx2tm1Rsd/Barx2tm1Rsd
Dmdmdx/Y
involves: 129 * C57BL/6 * C57BL/10ScSn 		abnormal diaphragm morphology J:187799
abnormal gait J:187799
decreased body size J:187799
decreased locomotor activity J:187799
decreased muscle weight J:187799
impaired skeletal muscle regeneration J:187799
increased variability of skeletal muscle fiber size J:187799
kyphosis J:187799
postnatal lethality, incomplete penetrance J:187799
progressive muscle weakness J:187799
skeletal muscle endomysial fibrosis J:187799
skeletal muscle fiber necrosis J:187799
skeletal muscle fibrosis J:187799
thin diaphragm muscle J:187799
Barx2tm1Rsd/Barx2tm1Rsd
Dmdmdx/Dmdmdx
involves: 129 * C57BL/6 * C57BL/10ScSn 		abnormal diaphragm morphology J:187799
abnormal gait J:187799
decreased body size J:187799
decreased locomotor activity J:187799
decreased muscle weight J:187799
impaired skeletal muscle regeneration J:187799
increased variability of skeletal muscle fiber size J:187799
kyphosis J:187799
postnatal lethality, incomplete penetrance J:187799
progressive muscle weakness J:187799
skeletal muscle endomysial fibrosis J:187799
skeletal muscle fiber necrosis J:187799
skeletal muscle fibrosis J:187799
thin diaphragm muscle J:187799
Cav3tm1Ncnp/Cav3+
Dmdmdx/Dmdmdx
involves: 129S4/SvJae * C57BL/10 * C57BL/10ScSn 		abnormal intercostal muscle morphology J:150127
abnormal muscle development J:150127
abnormal muscle fiber morphology J:150127
centrally nucleated skeletal muscle fibers J:150127
Cmahtm1Avrk/Cmahtm1Avrk
Dmdmdx/Dmdmdx
involves: 129X1/SvJ * C57BL/10ScSn 		abnormal gait J:164594
cardiac muscle necrosis J:164594
dystrophic muscle J:164594
impaired coordination J:164594
increased macrophage cell number J:164594
increased monocyte cell number J:164594
muscle weakness J:164594
premature death J:164594
skeletal muscle fibrosis J:164594
Creb1tm1.1Berd/Creb1tm1.1Berd
Dmdmdx/Y
B.Cg-Creb1tm1.1Berd Dmdmdx 		enhanced skeletal muscle regeneration J:177923
skeletal muscle degeneration J:177923
Ctsstm1Hap/Ctsstm1Hap
Dmdmdx/Dmdmdx
involves: 129S2/SvPas * C57BL/10ScSn 		abnormal skeletal muscle fiber morphology J:230788
centrally nucleated skeletal muscle fibers J:230788
dystrophic muscle J:230788
impaired exercise endurance J:230788
increased circulating creatine kinase level J:230788
skeletal muscle fiber necrosis J:230788
skeletal muscle fibrosis J:230788
Dag1tm1.1Swin/Dag1tm1.1Swin
Dmdmdx/Y
involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn 		centrally nucleated skeletal muscle fibers J:187750
increased circulating creatine kinase level J:187750
increased susceptibility to injury J:187750
Dag1tm1.1Swin/Dag1tm1.1Swin
Dmdmdx/Dmdmdx
involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn 		centrally nucleated skeletal muscle fibers J:187750
increased circulating creatine kinase level J:187750
increased susceptibility to injury J:187750
Dmdmdx-3Cv/Dmdmdx-3Cv
Utrntm1Ked/Utrntm1Ked
involves: 129 * C3H/HeHa * C57BL * M. m. castaneus * M. m. musculus 		abnormal skeletal muscle morphology J:116348
normal liver/biliary system phenotype J:116348
normal nervous system phenotype J:116348
normal renal/urinary system phenotype J:116348
normal reproductive system phenotype J:116348
normal respiratory system phenotype J:116348
Dmdmdx-3Cv/Y
Utrntm1Ked/Utrntm1Ked
involves: 129 * C3H/HeHa * C57BL * M. m. castaneus * M. m. musculus 		abnormal skeletal muscle morphology J:116348
normal liver/biliary system phenotype J:116348
normal nervous system phenotype J:116348
normal renal/urinary system phenotype J:116348
normal reproductive system phenotype J:116348
normal respiratory system phenotype J:116348
Dmdmdx-4Cv/Dmdmdx-4Cv
Myf5tm2Tajb/Myf5tm2Tajb
involves: 129S2/SvPas * C3H/HeHa * C57BL * M. m. castaneus * M. m. musculus 		increased skeletal muscle fiber diameter J:128921
skeletal muscle fiber necrosis J:128921
Dmdmdx-4Cv/Dmdmdx-4Cv
Terctm1Rdp/Terctm1Rdp
B6.Cg-Terctm1Rdp Dmdmdx-4Cv 		abnormal mitochondrial shape J:200365
abnormal myocardial fiber morphology J:200365
cardiac fibrosis J:200365
decreased heart ventricle muscle contractility J:200365
decreased mitochondrial size J:200365
decreased telomere length J:200365
dilated cardiomyopathy J:200365
dilated heart left ventricle J:200365
disorganized mitochondrial cristae J:200365
increased heart left ventricle size J:200365
increased mitochondrial number J:200365
oxidative stress J:200365
premature death J:200365
prolonged QRS complex duration J:200365
ventricular cardiomyopathy J:200365
Dmdmdx-5Cv/Dmdmdx-5Cv
Flt1tm1Jrt/Flt1+
involves: C3HA * C57BL/6Ros 		abnormal blood circulation J:164891
abnormal muscle contractility J:164891
abnormal muscle development J:164891
abnormal skeletal muscle fiber morphology J:164891
abnormal skeletal muscle fiber size J:164891
increased capillary density J:164891
increased satellite cell number J:164891
normal muscle phenotype J:164891
Dmdmdx-5Cv/Dmdmdx-5Cv
Flt1tm1Jrt/Flt1+
Utrntm1Jrs/Utrntm1Jrs
involves: 129S1/Sv * 129X1/SvJ * C3HA * C57BL/6Ros 		centrally nucleated skeletal muscle fibers J:164891
extended life span J:164891
increased body weight J:164891
Dmdmdx/Dmd+
Nos1tm1Plh/Nos1tm1Plh
involves: 129S4/SvJae * C57BL/10ScSn 		abnormal circulating pyruvate kinase level J:48851
dystrophic muscle J:48851
Dmdmdx/Dmd+
Foxk1tm1Djg/Foxk1+
involves: 129S4/SvJae * C57BL/10ScSn 		decreased body size J:62225
skeletal muscle necrosis J:62225
Dmdmdx/Dmdmdx
Dusp1tm1Brv/Dusp1tm1Brv
involves: 129S2/SvPas * C57BL/6 * C57BL/10ScSn 		decreased body size J:162340
decreased body weight J:162340
decreased grip strength J:162340
decreased skeletal muscle fiber diameter J:162340
decreased skeletal muscle fiber size J:162340
decreased skeletal muscle weight J:162340
dystrophic muscle J:162340
myositis J:162340
skeletal muscle fiber degeneration J:162340
Dmdmdx/Dmdmdx
Foxk1tm1Djg/Foxk1tm1Djg
involves: 129S4/SvJae * C57BL/10ScSn 		decreased locomotor activity J:62225
postnatal lethality, incomplete penetrance J:62225
premature death J:62225
skeletal muscle fibrosis J:62225
skeletal muscle necrosis J:62225
weakness J:62225
Dmdmdx/Dmdmdx
Mamstrtm1.2Eno/Mamstrtm1.2Eno
involves: 129 * C57BL/6 * C57BL/10ScSn 		abnormal skeletal muscle satellite cell proliferation J:179880
decreased body weight J:179880
decreased skeletal muscle weight J:179880
muscle degeneration J:179880
skeletal muscle fibrosis J:179880
Dmdmdx/Dmdmdx
Mmp9tm1Tvu/Mmp9+
B10.Cg-Mmp9tm1Tvu Dmdmdx 		abnormal muscle morphology J:150030
abnormal muscle physiology J:150030
decreased macrophage cell number J:150030
enhanced skeletal muscle regeneration J:150030
Dmdmdx/Dmdmdx
Mmp9tm1Tvu/Mmp9tm1Tvu
B10.Cg-Mmp9tm1Tvu Dmdmdx 		abnormal muscle morphology J:150030
decreased macrophage cell number J:150030
enhanced skeletal muscle regeneration J:150030
Dmdmdx/Dmdmdx
Prkdcscid/Prkdcscid
involves: BALB/c * C57BL/10ScSn * C57BL/Ka 		abnormal vertebral column morphology J:125527
absent CD4-positive, alpha-beta T cells J:125527
absent CD8-positive, alpha-beta T cells J:125527
centrally nucleated skeletal muscle fibers J:125527
decreased B cell number J:125527
decreased transforming growth factor beta level J:125527
impaired exercise endurance J:125527
impaired skeletal muscle contractility J:125527
increased skeletal muscle fiber diameter J:125527
reduced fertility J:125527
skeletal muscle fiber degeneration J:125527
skeletal muscle fibrosis J:125527
Dmdmdx/Dmdmdx
Selenostm1.1Sfa/Selenos+
involves: C57BL/6 * C57BL/10ScSn 		abnormal respiratory quotient J:266872
abnormal skeletal muscle fiber type ratio J:266872
decreased body mass index J:266872
decreased lean body mass J:266872
increased carbon dioxide production J:266872
increased oxygen consumption J:266872
normal muscle phenotype J:266872
Dmdmdx/Dmdmdx
Snhg15tm1Nju/Snhg15tm1Nju
involves: C57BL/6J * C57BL/10ScSn 		normal growth/size/body region phenotype J:291983
impaired skeletal muscle regeneration J:291983
increased variability of skeletal muscle fiber size J:291983
normal muscle phenotype J:291983
skeletal muscle fibrosis J:291983
Dmdmdx/Dmdmdx
Spp1tm1Blh/Spp1tm1Blh
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn 		abnormal muscle physiology J:150572
abnormal physical strength J:150572
decreased granulocyte number J:150572
decreased neutrophil cell number J:150572
decreased T cell number J:150572
increased regulatory T cell number J:150572
increased T cell number J:150572
Dmdmdx/Dmdmdx
Tg(ACTA1-SSPN)3.0Rcros/0
involves: C57BL/10ScSn 		abnormal sarcolemma morphology J:185346
centrally nucleated skeletal muscle fibers J:185346
dystrophic muscle J:185346
Dmdmdx/Dmdmdx
Utrntm1Jrs/Utrntm1Jrs
involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn 		abnormal gait J:42389
abnormal limb morphology J:42389, J:59675
abnormal muscle physiology J:42389
abnormal muscle relaxation J:42389
abnormal neuromuscular synapse morphology J:42389, J:60776
cardiomyopathy J:42389, J:59675
decreased body size J:42389
dystrophic muscle J:42389, J:59675
kyphosis J:42389, J:59675
muscle degeneration J:42389
muscle weakness J:42389
myocardium necrosis J:42389
postnatal growth retardation J:42389, J:59675
premature death J:42389, J:59675
skeletal muscle interstitial fibrosis J:42389
skeletal muscle necrosis J:42389
Dmdmdx/Dmdmdx
Utrntm1Ked/Utrntm1Ked
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA 		abnormal breathing pattern J:42388
abnormal gait J:42388
abnormal hindlimb morphology J:42388
abnormal neuromuscular synapse morphology J:42388
abnormal posture J:42388
abnormal skeletal muscle fiber morphology J:42388
abnormal skeletal muscle fiber size J:42388
centrally nucleated skeletal muscle fibers J:42388
decreased locomotor activity J:42388
dystrophic muscle J:42388
kyphosis J:42388
premature death J:42388
progressive muscle weakness J:42388
skeletal muscle interstitial fibrosis J:42388
skeletal muscle necrosis J:42388
weight loss J:42388
Dmdmdx/Y
Dtnatm1Jrs/Dtnatm1Jrs
involves: 129X1/SvJ * C57BL/10ScSn 		abnormal neuromuscular synapse morphology J:60776
cardiomyopathy J:59675
dystrophic muscle J:59675
premature death J:59675
Dmdmdx/Y
Dtnatm1Jrs/Dtnatm1Jrs
Utrntm1Jrs/Utrntm1Jrs
involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn 		abnormal limb morphology J:59675
abnormal neuromuscular synapse morphology J:60776
cardiomyopathy J:59675
dystrophic muscle J:59675
kyphosis J:59675
postnatal growth retardation J:59675
postnatal lethality, incomplete penetrance J:59675
premature death J:59675
skeletal muscle necrosis J:59675
Dmdmdx/?
Fgf2tm1Zllr/Fgf2tm1Zllr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn 		dystrophic muscle J:85088
Dmdmdx/?
Fgf2tm1Zllr/Fgf2tm1Zllr
Fgf6tm1Thbr/Fgf6tm1Thbr
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/10ScSn 		abnormal muscle physiology J:85088
abnormal skeletal muscle fiber morphology J:85088
abnormal skeletal muscle morphology J:85088
abnormal spine curvature J:85088
decreased satellite cell number J:85088
dystrophic muscle J:85088
increased variability of skeletal muscle fiber size J:85088
normal muscle phenotype J:85088
skeletal muscle fiber necrosis J:85088
Dmdmdx/?
Fgf6tm1Thbr/Fgf6tm1Thbr
involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn 		abnormal diaphragm morphology J:42574
abnormal epaxial muscle morphology J:42574
abnormal hypaxial muscle morphology J:42574
abnormal spine curvature J:42574
dystrophic muscle J:85088
normal muscle phenotype J:42574
myopathy J:42574
Dmdmdx/Y
Foxk1tm1Djg/Foxk1tm1Djg
involves: 129S4/SvJae * C57BL/10ScSn 		decreased locomotor activity J:62225
postnatal lethality, incomplete penetrance J:62225
premature death J:62225
skeletal muscle fibrosis J:62225
skeletal muscle necrosis J:62225
weakness J:62225
Dmdmdx/Y
Foxn1nu/Foxn1nu
involves: C57BL/10ScSn 		abnormal muscle morphology J:95776
decreased skeletal muscle fiber size J:95776
increased skeletal muscle fiber size J:95776
Dmdmdx/Y
Mirc37tm1Boet/Mirc37tm1Boet
involves: C57BL/10ScSn 		dystrophic muscle J:241493
increased creatine kinase activity J:241493
Dmdmdx/?
Myod1tm1Jae/Myod1tm1Jae
involves: 129S4/SvJae * C57BL/10ScSn 		abnormal heart ventricle morphology J:52248
cardiac fibrosis J:52248
cardiac interstitial fibrosis J:52248
dilated cardiomyopathy J:52248
increased heart weight J:52248
increased myocardial fiber size J:52248
myocardium necrosis J:52248
premature death J:52248
Dmdmdx/Y
Nos1tm1Plh/Nos1tm1Plh
involves: 129S4/SvJae * C57BL/10ScSn 		abnormal circulating pyruvate kinase level J:48851
dystrophic muscle J:48851
Dmdmdx/Y
Spp1tm1Blh/Spp1tm1Blh
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn 		abnormal muscle physiology J:150572
abnormal physical strength J:150572
decreased granulocyte number J:150572
decreased neutrophil cell number J:150572
decreased T cell number J:150572
increased regulatory T cell number J:150572
increased T cell number J:150572
Dmdmdx/Y
Terctm1Rdp/Terc+
involves: 129/Sv * C57BL/6J * C57BL/10ScSn * SJL 		abnormal diaphragm morphology J:167294
abnormal muscle physiology J:167294
centrally nucleated skeletal muscle fibers J:167294
increased circulating creatine kinase level J:167294
Dmdmdx/Y
Terctm1Rdp/Terctm1Rdp
involves: 129/Sv * C57BL/6J * C57BL/10ScSn * SJL 		abnormal diaphragm morphology J:167294
abnormal muscle electrophysiology J:167294
abnormal muscle physiology J:167294
abnormal skeletal muscle morphology J:167294
calcified muscle J:167294
centrally nucleated skeletal muscle fibers J:167294
chromosomal instability J:167294
decreased satellite cell number J:167294
decreased telomere length J:167294
dystrophic muscle J:167294
impaired exercise endurance J:167294
increased circulating creatine kinase level J:167294
increased variability of skeletal muscle fiber size J:167294
kyphosis J:167294
muscle weakness J:167294
muscular atrophy J:167294
myositis J:167294
premature death J:167294
respiratory failure J:167294
skeletal muscle degeneration J:167294
skeletal muscle fibrosis J:167294
skeletal muscle necrosis J:167294
Dmdmdx/Y
Tg(DMD*)#Spc/0
involves: 129P2/OlaHsd * C57BL/10ScSn * DBA/2 		abnormal calcium level J:280218
dystrophic muscle J:280218
myositis J:280218
skeletal muscle fibrosis J:280218
Dmdmdx/Y
Utrntm1Jrs/Utrn+
involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn 		diaphragmitis J:140282
myositis J:140282
skeletal muscle endomysial fibrosis J:140282
Dmdtm1.1Know/Dmdtm1.1Know
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Tg(Myh6-2A)#Know/0
involves: BALB/c * C3H * C57BL/6 * FVB/N 		abnormal heart echocardiography feature J:207775
cardiac fibrosis J:207775
cardiomyopathy J:207775
decreased susceptibility to injury J:207775
increased cardiac muscle contractility J:207775
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory