Dnmt1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dnmt1
DNA methyltransferase 1
MGI:94912

31 phenotypes from 11 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dnmt1^em1Jiemw/Dnmt1^em1Jiemw C57BL/6-Dnmt1^em1Jiemw	prenatal lethality, complete penetrance	J:310870
Dnmt1^em2Jiemw/Dnmt1⁺ C57BL/6-Dnmt1^em2Jiemw	abnormal response to novel object	J:310870
	abnormal spatial reference memory	J:310870
	abnormal spatial working memory	J:310870
	decreased neuron number	J:310870
	decreased neuronal stem cell self-renewal	J:310870
	impaired spatial learning	J:310870
	increased neuron apoptosis	J:310870
Dnmt1^em2Jiemw/Dnmt1^em2Jiemw C57BL/6-Dnmt1^em2Jiemw	embryonic lethality prior to tooth bud stage, complete penetrance	J:310870
Dnmt1^MommeD2/Dnmt1⁺ FVB/NJ-Dnmt1^MommeD2	prenatal lethality, incomplete penetrance	J:99816
Dnmt1^MommeD2/Dnmt1^MommeD2 FVB/NJ-Dnmt1^MommeD2	preweaning lethality, complete penetrance	J:99816
Dnmt1^tm1Enl/Dnmt1^tm1Enl involves: 129S4/SvJae	abnormal DNA methylation	J:36234
	abnormal neural tube morphology	J:36234
	absent somites	J:36234
	embryonic growth arrest	J:36234
	embryonic lethality, complete penetrance	J:36234
Dnmt1^tm1Enl/Dnmt1^tm1Enl involves: 129S4/SvJae * C57BL/6	abnormal DNA methylation	J:116773
Dnmt1^tm1Jae/Dnmt1^tm1Jae involves: 129S4/SvJae	abnormal DNA methylation	J:1157
	abnormal embryonic tissue morphology	J:1157
	abnormal imprinting	J:110857
	decreased cell proliferation	J:1157
	embryonic growth arrest	J:1157
	embryonic lethality, complete penetrance	J:1157
	increased embryonic tissue cell apoptosis	J:1157
	pale yolk sac	J:1157
	small visceral yolk sac	J:1157
Dnmt1^tm1Jae/Dnmt1^tm1Pwl involves: 129S4/SvJae	normal growth/size/body region phenotype	J:75230
Dnmt1^tm1Jrc/Dnmt1^tm1Jrc involves: 129S1/Sv	abnormal imprinting	J:68455
Dnmt1^tm1Jrc/Dnmt1^tm1Jrc involves: 129S1/Sv	female infertility	J:68455
Dnmt1^tm1Jrc/Dnmt1^tm1Jrc involves: 129S1/Sv * FVB/N	abnormal imprinting	J:135338
Dnmt1^tm1Okan/Dnmt1^tm2Enl involves: 129S4/SvJae	decreased cell proliferation	J:129049
	embryonic growth arrest	J:129049
	failure of initiation of embryo turning	J:129049
	failure of somite differentiation	J:129049
	open neural tube	J:129049
Dnmt1^tm2Enl/Dnmt1^tm2Enl involves: 129S4/SvJae	abnormal DNA methylation	J:36234
	abnormal neural tube morphology	J:36234
	decreased cell proliferation	J:129049
	embryonic growth arrest	J:36234, J:129049
	embryonic lethality, complete penetrance	J:36234
	failure of initiation of embryo turning	J:129049
	failure of somite differentiation	J:129049
	impaired somite development	J:36234
	open neural tube	J:129049
Dnmt1^tm2Jae/Dnmt1^tm2Jae Cd79a^tm1(cre)Reth/Cd79a⁺ involves: 129S4/SvJae * BALB/c * C57BL/6	abnormal B cell differentiation	J:113645
	decreased pro-B cell number	J:113645
Dnmt1^tm2Jrc/Dnmt1^tm2Jrc involves: 129S1/Sv	no abnormal phenotype detected	J:126389

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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