Dnmt1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dnmt1
DNA methyltransferase 1
MGI:94912

31 phenotypes from 11 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dnmt1^em1Jiemw/Dnmt1^em1Jiemw C57BL/6-Dnmt1^em1Jiemw	prenatal lethality, complete penetrance	J:310870
Dnmt1^em2Jiemw/Dnmt1⁺ C57BL/6-Dnmt1^em2Jiemw	abnormal response to novel object	J:310870
	abnormal spatial reference memory	J:310870
	abnormal spatial working memory	J:310870
	decreased neuron number	J:310870
	decreased neuronal stem cell self-renewal	J:310870
	impaired spatial learning	J:310870
	increased neuron apoptosis	J:310870
Dnmt1^em2Jiemw/Dnmt1^em2Jiemw C57BL/6-Dnmt1^em2Jiemw	embryonic lethality prior to tooth bud stage, complete penetrance	J:310870
Dnmt1^MommeD2/Dnmt1⁺ FVB/NJ-Dnmt1^MommeD2	prenatal lethality, incomplete penetrance	J:99816
Dnmt1^MommeD2/Dnmt1^MommeD2 FVB/NJ-Dnmt1^MommeD2	preweaning lethality, complete penetrance	J:99816
Dnmt1^tm1Enl/Dnmt1^tm1Enl involves: 129S4/SvJae	abnormal DNA methylation	J:36234
	abnormal neural tube morphology	J:36234
	absent somites	J:36234
	embryonic growth arrest	J:36234
	embryonic lethality, complete penetrance	J:36234
Dnmt1^tm1Enl/Dnmt1^tm1Enl involves: 129S4/SvJae * C57BL/6	abnormal DNA methylation	J:116773
Dnmt1^tm1Jae/Dnmt1^tm1Jae involves: 129S4/SvJae	abnormal DNA methylation	J:1157
	abnormal embryonic tissue morphology	J:1157
	abnormal imprinting	J:110857
	decreased cell proliferation	J:1157
	embryonic growth arrest	J:1157
	embryonic lethality, complete penetrance	J:1157
	increased embryonic tissue cell apoptosis	J:1157
	pale yolk sac	J:1157
	small visceral yolk sac	J:1157
Dnmt1^tm1Jae/Dnmt1^tm1Pwl involves: 129S4/SvJae	normal growth/size/body region phenotype	J:75230
Dnmt1^tm1Jrc/Dnmt1^tm1Jrc involves: 129S1/Sv	abnormal imprinting	J:68455
Dnmt1^tm1Jrc/Dnmt1^tm1Jrc involves: 129S1/Sv	female infertility	J:68455
Dnmt1^tm1Jrc/Dnmt1^tm1Jrc involves: 129S1/Sv * FVB/N	abnormal imprinting	J:135338
Dnmt1^tm1Okan/Dnmt1^tm2Enl involves: 129S4/SvJae	decreased cell proliferation	J:129049
	embryonic growth arrest	J:129049
	failure of initiation of embryo turning	J:129049
	failure of somite differentiation	J:129049
	open neural tube	J:129049
Dnmt1^tm2Enl/Dnmt1^tm2Enl involves: 129S4/SvJae	abnormal DNA methylation	J:36234
	abnormal neural tube morphology	J:36234
	decreased cell proliferation	J:129049
	embryonic growth arrest	J:36234, J:129049
	embryonic lethality, complete penetrance	J:36234
	failure of initiation of embryo turning	J:129049
	failure of somite differentiation	J:129049
	impaired somite development	J:36234
	open neural tube	J:129049
Dnmt1^tm2Jae/Dnmt1^tm2Jae Cd79a^tm1(cre)Reth/Cd79a⁺ involves: 129S4/SvJae * BALB/c * C57BL/6	abnormal B cell differentiation	J:113645
	decreased pro-B cell number	J:113645
Dnmt1^tm2Jrc/Dnmt1^tm2Jrc involves: 129S1/Sv	no abnormal phenotype detected	J:126389

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24